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    Ppfia1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 233977, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ppfia1provided by MGI
    Official Full Name
    protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1provided by MGI
    Primary source
    MGI:MGI:1924750
    See related
    Ensembl:ENSMUSG00000037519 AllianceGenome:MGI:1924750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LIP1; LIP.1; C030014K08Rik
    Summary
    Acts upstream of or within negative regulation of stress fiber assembly. Predicted to be located in several cellular components, including axon; dendrite; and focal adhesion. Predicted to be part of protein-containing complex. Predicted to be active in Schaffer collateral - CA1 synapse; presynaptic active zone; and spine apparatus. Is expressed in several structures, including blood vessel endothelium; central nervous system; genitourinary system; retina; and spleen. Orthologous to human PPFIA1 (PTPRF interacting protein alpha 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 13.1), CNS E11.5 (RPKM 12.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppfia1 in Genome Data Viewer
    Location:
    7 F5; 7 88.85 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144030492..144107497, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (144476755..144553762, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34561 Neighboring gene cortactin Neighboring gene STARR-positive B cell enhancer ABC_E6619 Neighboring gene STARR-positive B cell enhancer ABC_E9306 Neighboring gene predicted gene, 35626 Neighboring gene Fas associated via death domain Neighboring gene anoctamin 1, calcium activated chloride channel Neighboring gene RIKEN cDNA D930030F02 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of mouse Ppfia1 gene in silico. Katoh M, et al. Int J Mol Med, 2003 Aug. PMID 12851729
    2. Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development. Huang H, et al. Proc Natl Acad Sci U S A, 2017 Aug 15. PMID 28760951, Free PMC Article
    3. Liprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery. Bernadzki KM, et al. Sci Rep, 2017 Aug 22. PMID 28831123, Free PMC Article
    4. Liprin-α controls stress fiber formation by binding to mDia and regulating its membrane localization. Sakamoto S, et al. J Cell Sci, 2012 Jan 1. PMID 22266902
    5. The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing. Zürner M, et al. Genomics, 2009 Mar. PMID 19013515

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we found that liprin-alpha-1 plays an important role in AChR clustering and the organization of cortical microtubules. Our studies provide novel insights into the function of liprin-alpha-1 at vertebrate neuromuscular synapses.
      Title: Liprin-α-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery.
    2. findings collectively demonstrate that the Cdk5-dependent phosphorylation of liprinalpha1 is important for the postsynaptic organization during activity-dependent synapse development.
      Title: Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development.
    3. results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity.
      Title: The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189815, MGC189929

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spine apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    liprin-alpha-1
    Names
    Liprin-alpha1
    liprin

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033319.2 → NP_001028491.1  liprin-alpha-1 isoform B

      See identical proteins and their annotated locations for NP_001028491.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) lacks an in-frame exon in the 5' coding region, compared to variant A. The resulting protein (isoform B) is shorter than isoform A.
      Source sequence(s)
      AC140268, AC153792
      Consensus CDS
      CCDS52464.1
      UniProtKB/TrEMBL
      B2RXW8, B8QI33
      Related
      ENSMUSP00000126233.3, ENSMUST00000168134.10
      Conserved Domains (7) summary
      cd09562
      Location:884 → 954
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1001 → 1066
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1086 → 1157
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1087 → 1157
      SAM; Sterile alpha motif
      COG1842
      Location:302 → 515
      PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
      cl03951
      Location:406 → 514
      CDC37_N; Cdc37 N terminal kinase binding
      cl12013
      Location:323 → 444
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_001195086.1 → NP_001182015.1  liprin-alpha-1 isoform A

      See identical proteins and their annotated locations for NP_001182015.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AC140268, AC153792
      Consensus CDS
      CCDS59738.1
      UniProtKB/TrEMBL
      B2RXQ2, B8QI33
      Related
      ENSMUSP00000138312.2, ENSMUST00000182226.8
      Conserved Domains (7) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1026 → 1091
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1111 → 1182
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:1112 → 1182
      SAM; Sterile alpha motif
      COG1842
      Location:302 → 540
      PspA; Phage shock protein A [Transcription, Signal transduction mechanisms]
      pfam00836
      Location:406 → 523
      Stathmin; Stathmin family
      cl12013
      Location:323 → 469
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      144030492..144107497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508610.4 → XP_006508673.1  liprin-alpha-1 isoform X22

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:874 → 944
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:961 → 1026
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1046 → 1117
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:171 → 516
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:412 → 663
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. XM_017322222.3 → XP_017177711.1  liprin-alpha-1 isoform X16

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:874 → 944
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:991 → 1056
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1076 → 1147
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:171 → 516
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:412 → 663
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    3. XM_036153023.1 → XP_036008916.1  liprin-alpha-1 isoform X10

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:874 → 944
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1012 → 1077
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1097 → 1168
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:171 → 516
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:389 → 660
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    4. XM_011241995.4 → XP_011240297.1  liprin-alpha-1 isoform X6

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:884 → 954
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1022 → 1087
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1107 → 1178
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:171 → 516
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:412 → 663
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    5. XM_006508609.5 → XP_006508672.1  liprin-alpha-1 isoform X19

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:899 → 969
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:986 → 1051
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1071 → 1142
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_017322223.3 → XP_017177712.1  liprin-alpha-1 isoform X18

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:899 → 969
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:987 → 1052
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1072 → 1143
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. XM_017322220.3 → XP_017177709.1  liprin-alpha-1 isoform X8

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:899 → 969
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1016 → 1081
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1101 → 1172
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_011241991.4 → XP_011240293.1  liprin-alpha-1 isoform X2

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:899 → 969
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1037 → 1102
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1122 → 1193
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_036153025.1 → XP_036008918.1  liprin-alpha-1 isoform X20

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (6) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:996 → 1061
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1081 → 1152
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:421 → 685
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    10. XM_006508608.5 → XP_006508671.1  liprin-alpha-1 isoform X15

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:996 → 1061
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1081 → 1152
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    11. XM_006508607.5 → XP_006508670.1  liprin-alpha-1 isoform X14

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:997 → 1062
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1082 → 1153
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. XM_006508605.5 → XP_006508668.1  liprin-alpha-1 isoform X13

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1005 → 1070
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1090 → 1161
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    13. XM_006508603.5 → XP_006508666.1  liprin-alpha-1 isoform X11

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1006 → 1071
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1091 → 1162
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    14. XM_006508599.5 → XP_006508662.1  liprin-alpha-1 isoform X5

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1026 → 1091
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1111 → 1182
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    15. XM_006508604.5 → XP_006508667.1  liprin-alpha-1 isoform X12

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1017 → 1082
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1102 → 1173
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    16. XM_006508601.5 → XP_006508664.1  liprin-alpha-1 isoform X7

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1017 → 1082
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1102 → 1173
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    17. XM_017322221.3 → XP_017177710.1  liprin-alpha-1 isoform X9

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1027 → 1092
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1112 → 1183
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    18. XM_006508598.5 → XP_006508661.1  liprin-alpha-1 isoform X4

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1027 → 1092
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1112 → 1183
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    19. XM_011241992.4 → XP_011240294.1  liprin-alpha-1 isoform X3

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1047 → 1112
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1132 → 1203
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    20. XM_030242539.2 → XP_030098399.1  liprin-alpha-1 isoform X23

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:874 → 944
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:962 → 1027
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1047 → 1118
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:171 → 516
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:412 → 663
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    21. XM_006508612.4 → XP_006508675.1  liprin-alpha-1 isoform X26

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:884 → 954
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:992 → 1057
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1077 → 1148
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:171 → 516
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:412 → 663
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    22. XM_011241996.4 → XP_011240298.1  liprin-alpha-1 isoform X1

      See identical proteins and their annotated locations for XP_011240298.1

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1047 → 1112
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1132 → 1203
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    23. XM_011241997.2 → XP_011240299.1  liprin-alpha-1 isoform X25

      Conserved Domains (3) summary
      cd09562
      Location:256 → 326
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:394 → 459
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:479 → 550
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

    24. XM_006508611.4 → XP_006508674.1  liprin-alpha-1 isoform X24

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:874 → 944
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:961 → 1026
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1046 → 1117
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:171 → 516
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:412 → 663
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    25. XM_017322224.3 → XP_017177713.1  liprin-alpha-1 isoform X21

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (5) summary
      cd09562
      Location:899 → 969
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:986 → 1051
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1071 → 1142
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    26. XM_036153024.1 → XP_036008917.1  liprin-alpha-1 isoform X17

      UniProtKB/TrEMBL
      B8QI33
      Conserved Domains (6) summary
      cd09562
      Location:909 → 979
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1047 → 1112
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1132 → 1203
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:45 → 418
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:246 → 545
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:421 → 685
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    Nucleotide Protein Strain
    Heading Accession and Version

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