H60a histocompatibility 60a [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: H60aprovided by MGI
Official Full Name: histocompatibility 60aprovided by MGI
Primary source: MGI:MGI:1306817
See related: AllianceGenome:MGI:1306817
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H60
Summary: Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within several processes, including positive regulation of biosynthetic process; positive regulation of immune response; and positive regulation of leukocyte activation. Located in external side of plasma membrane. Is expressed in embryo and spleen. [provided by Alliance of Genome Resources, Oct 2024]
Annotation information: not in current annotation release
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Genomic context

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See H60a in Genome Data Viewer

Location:: chromosome: 10

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

T cells with low avidity for hematopoietic minor H antigen H60 (H60) that escape the thymic deletion have effector differentiation potential in the periphery.
Title: Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen.
After PSK administration, INF-g production in CD8(+) T cells increased in mice with cells expressing neither Rae-1 nor H60, but did not change in mice implanted with cells expressing both Rae-1 and H60. We demonstrated that the expression of NKG2DLs affects tumor immunity and the efficacy of immuno therapy in tumor-bearing mouse model
Title: Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models.
Our studies show that the expression of H60a on tumors cells can be actively modulated by the immune system
Title: Cancer immunoediting of the NK group 2D ligand H60a.
tumour cells that constitutively express H60a at the cell surface can be recognized by H60a-specific T cells
Title: Studies on the antigenicity of the NKG2D ligand H60a in tumour cells.
The genomic locus of H60a in 129/Sv and C57BL/6 strains, was examined.
Title: Studies of the H60a locus in C57BL/6 and 129/Sv mouse strains identify the H60a 3'UTR as a regulator of H60a expression.
Embryonic stem cell-derived hematopoietic progenitor cells (HPCs) express high levels of H60, rendering HPCs susceptible to natural killer (NK) cell killing in vitro and in vivo.
Title: HOXB4-transduced embryonic stem cell-derived Lin-c-kit+ and Lin-Sca-1+ hematopoietic progenitors express H60 and are targeted by NK cells.
Hsp70-peptide complexes-induced tolerance for experimental autoimmune encephalomyelitis, mediated by NK cells, involves induction of H60 ligand and its interaction with natural killer cell group 2D receptor
Title: EAE tolerance induction with Hsp70-peptide complexes depends on H60 and NKG2D activity.
mouse cytomegalovirus m155 gene encodes a protein that interferes with the expression of H60 on the surfaces of infected cells
Title: Selective down-regulation of the NKG2D ligand H60 by mouse cytomegalovirus m155 glycoprotein.
Mouse cytomegalovirus (MCMV) molecule fcr-1 promotes a rapid down-regulation of NKG2D ligands murine UL16-binding protein like transcript (MULT)-1 and H60 from the cell surface.
Title: The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60.
Hepatic ischemia/reperfusion injury increrases gene expression.
Title: Yisheng injection decreases the expression of H60 and RAE-1 genes in ischemic mice liver.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Not Applicable (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H60 (e-PCR), detects polymorphism
- UniSTS:256436

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables natural killer cell lectin-like receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of immune response to tumor cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell activation	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within susceptibility to natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histocompatibility 60a

Names: histocompatibility 60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010400.2 → NP_034530.1 histocompatibility 60a precursor

See identical proteins and their annotated locations for NP_034530.1

Status: PROVISIONAL

Source sequence(s)

AK169909

UniProtKB/TrEMBL

O77968, Q3TDZ7

Conserved Domains (1) summary

cl08246
Location:61 → 178

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2