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    FAA2 medium-chain fatty acid-CoA ligase FAA2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856734, updated on 28-Oct-2024

    Summary

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    Official Symbol
    FAA2
    Official Full Name
    medium-chain fatty acid-CoA ligase FAA2
    Primary source
    SGD:S000000817
    Locus tag
    YER015W
    See related
    AllianceGenome:SGD:S000000817; FungiDB:YER015W; VEuPathDB:YER015W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FAM1
    Summary
    Enables long-chain fatty acid-CoA ligase activity; medium-chain fatty acid-CoA ligase activity; and very long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid metabolic process. Located in peroxisome. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congenital diarrhea; and leukemia. Orthologous to several human genes including ACSL1 (acyl-CoA synthetase long chain family member 1) and ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See FAA2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (184541..186775)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene DEAH-box ATP-dependent RNA helicase PRP22 Neighboring gene oxygen-dependent protoporphyrinogen oxidase Neighboring gene Bud25p Neighboring gene microtubule-binding protein BIM1 Neighboring gene AAA family ATPase AFG3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peroxisomal membrane protein Pmp47 is essential in the metabolism of middle-chain fatty acid in yeast peroxisomes and Is associated with peroxisome proliferation. Nakagawa T, et al. J Biol Chem, 2000 Feb 4. PMID 10652339
    2. Subcellular relocalization of a long-chain fatty acid CoA ligase by a suppressor mutation alleviates a respiration deficiency in Saccharomyces cerevisiae. Harington A, et al. EMBO J, 1994 Dec 1. PMID 7988550, Free PMC Article
    3. De novo biosynthesis of 8-hydroxyoctanoic acid via a medium-chain length specific fatty acid synthase and cytochrome P450 in Saccharomyces cerevisiae. Wernig F, et al. Metab Eng Commun, 2020 Jun. PMID 31867212, Free PMC Article
    4. Comparison of the reactivity of tetradecenoic acids, a triacsin, and unsaturated oximes with four purified Saccharomyces cerevisiae fatty acid activation proteins. Knoll LJ, et al. J Biol Chem, 1995 Aug 25. PMID 7650027
    5. Biochemical studies of three Saccharomyces cerevisiae acyl-CoA synthetases, Faa1p, Faa2p, and Faa3p. Knoll LJ, et al. J Biol Chem, 1994 Jun 10. PMID 8206942

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables decanoate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables very long-chain fatty acid-CoA ligase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    medium-chain fatty acid-CoA ligase FAA2
    NP_010931.3
    • Medium chain fatty acyl-CoA synthetase; activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      184541..186775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178906.3 → NP_010931.3  TPA: medium-chain fatty acid-CoA ligase FAA2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010931.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLR3, P39518
      UniProtKB/TrEMBL
      A6ZQW3, B3LS27, C8Z716
      Conserved Domains (1) summary
      cd05927
      Location:126 → 734
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39518.1

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