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    Tes testin LIM domain protein [ Mus musculus (house mouse) ]

    Gene ID: 21753, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tesprovided by MGI
    Official Full Name
    testin LIM domain proteinprovided by MGI
    Primary source
    MGI:MGI:105081
    See related
    Ensembl:ENSMUSG00000029552 AllianceGenome:MGI:105081
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TESS; Tes1; Tes2; testin2; D6Ertd352e
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and metanephros. Orthologous to human TES (testin LIM domain protein). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in bladder adult (RPKM 40.0), large intestine adult (RPKM 38.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tes in Genome Data Viewer
    Location:
    6 A2; 6 7.67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (17065148..17105824)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (17065149..17105825)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transcription factor EC Neighboring gene STARR-seq mESC enhancer starr_15248 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:17015482-17015727 Neighboring gene predicted gene 15473 Neighboring gene predicted gene 4876 Neighboring gene STARR-seq mESC enhancer starr_15252 Neighboring gene predicted gene, 53251 Neighboring gene RIKEN cDNA D830026I12 gene Neighboring gene predicted gene, 52892 Neighboring gene caveolin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockout mice reveal a tumor suppressor function for Testin. Drusco A, et al. Proc Natl Acad Sci U S A, 2005 Aug 2. PMID 16033868, Free PMC Article
    2. Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice. Weeks RJ, et al. Sci Rep, 2020 Oct 1. PMID 33004921, Free PMC Article
    3. Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. Tatarelli C, et al. Genomics, 2000 Aug 15. PMID 10950921
    4. Testin protects against cardiac hypertrophy by targeting a calcineurin-dependent signalling pathway. Gao L, et al. J Cell Mol Med, 2019 Jan. PMID 30467953, Free PMC Article
    5. Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption. Hadzic E, et al. PLoS One, 2015. PMID 26509500, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of testin is downregulated in murine hypertrophic hearts.Testin serves as a crucial regulator of the hypertrophic reaction by hindering the calcineurin-dependent pathway in the heart.
      Title: Testin protects against cardiac hypertrophy by targeting a calcineurin-dependent signalling pathway.
    2. zyxin influences focal adhesion dynamics, that it recruits Tes and that this interaction is functional in regulating cell spreading.
      Title: Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption.
    3. Testin is a mammalian gene involved in coordinated orientation of hair cells in the inner ear and in the development of the female reproductive tract.
      Title: Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice.
    4. TES acts as a tumor suppressor in an established model of carcinogen-induced gastric cancer
      Title: Knockout mice reveal a tumor suppressor function for Testin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    testin
    Names
    TES1/TES2
    testin 2
    testis derived transcript

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207176.3 → NP_997059.1  testin

      See identical proteins and their annotated locations for NP_997059.1

      Status: VALIDATED

      Source sequence(s)
      AC159332
      Consensus CDS
      CCDS39429.1
      UniProtKB/TrEMBL
      Q3ULB1, Q921B1, Q921W7
      Related
      ENSMUSP00000111127.5, ENSMUST00000115467.11
      Conserved Domains (4) summary
      cd09413
      Location:234 → 291
      LIM1_Testin; The first LIM domain of Testin
      cd09416
      Location:297 → 352
      LIM2_Testin; The second LIM domain of Testin
      cd09419
      Location:359 → 417
      LIM3_Testin; The third LIM domain of Testin
      cd09829
      Location:109 → 196
      PET_testin; The PET domain of Testin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      17065148..17105824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_011570.3: Suppressed sequence

      Description
      NM_011570.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47226.1 GenPept UniProtKB/Swiss-Prot:P47226

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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