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    CDK12 cyclin dependent kinase 12 [ Homo sapiens (human) ]

    Gene ID: 51755, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CDK12provided by HGNC
    Official Full Name
    cyclin dependent kinase 12provided by HGNC
    Primary source
    HGNC:HGNC:24224
    See related
    Ensembl:ENSG00000167258 MIM:615514; AllianceGenome:HGNC:24224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRK7; CRKR; CRKRS
    Summary
    Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in several processes, including positive regulation of transcription elongation by RNA polymerase II; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. Biomarker of gastric adenocarcinoma; hepatocellular carcinoma; and stomach cancer. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in testis (RPKM 8.6), bone marrow (RPKM 8.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDK12 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (39461486..39567559)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (40325392..40431128)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37617739..37690797)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene F-box and leucine rich repeat protein 20 Neighboring gene microRNA 548BC Neighboring gene MPRA-validated peak2834 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:37489325-37489835 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:37493495-37494252 Neighboring gene Sharpr-MPRA regulatory region 12086 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37557132-37557424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8453 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8455 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8454 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:37558864-37559028 Neighboring gene mediator complex subunit 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:37618166-37619365 Neighboring gene U6 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 233, pseudogene Neighboring gene uncharacterized LOC105371770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37730809-37731383 Neighboring gene uncharacterized LOC105371771

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability. Choi SH, et al. Genes Dev, 2019 Apr 1. PMID 30819820, Free PMC Article
    2. Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity. Bajrami I, et al. Cancer Res, 2014 Jan 1. PMID 24240700, Free PMC Article
    3. CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma. Houles T, et al. Nat Commun, 2022 Oct 29. PMID 36309522, Free PMC Article
    4. Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors. Joshi PM, et al. J Biol Chem, 2014 Mar 28. PMID 24554720, Free PMC Article
    5. Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex. Bartkowiak B, et al. J Biol Chem, 2015 Jan 16. PMID 25429106, Free PMC Article

    See all (174) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDK12 is a promising therapeutic target for the transcription cycle and DNA damage response in metastatic osteosarcoma.
      Title: CDK12 is a promising therapeutic target for the transcription cycle and DNA damage response in metastatic osteosarcoma.
    2. Structure-independent machine-learning predictions of the CDK12 interactome.
      Title: Structure-independent machine-learning predictions of the CDK12 interactome.
    3. Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects.
      Title: Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects.
    4. Cyclin-dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration-resistant prostate cancer.
      Title: Cyclin-dependent kinase 12 deficiency reprogrammes cellular metabolism to alleviate ferroptosis potential and promote the progression of castration-resistant prostate cancer.
    5. Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2-Positive Disease.
      Title: Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2-Positive Disease.
    6. ERBB2-amplified lobular breast carcinoma exhibits concomitant CDK12 co-amplification associated with poor prognostic features.
      Title: ERBB2-amplified lobular breast carcinoma exhibits concomitant CDK12 co-amplification associated with poor prognostic features.
    7. Trans-Regulation of Alternative PD-L1 mRNA Processing by CDK12 in Non-Small-Cell Lung Cancer Cells.
      Title: Trans-Regulation of Alternative PD-L1 mRNA Processing by CDK12 in Non-Small-Cell Lung Cancer Cells.
    8. Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release.
      Title: Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release.
    9. CDK12 Promotes the Proliferation, Migration, and Angiogenesis of Gastric Carcinoma via Activating the PI3K/AKT/mTOR Signaling Pathway.
      Title: CDK12 Promotes the Proliferation, Migration, and Angiogenesis of Gastric Carcinoma via Activating the PI3K/AKT/mTOR Signaling Pathway.
    10. CDK12 loss inhibits cell proliferation by regulating TBK1 in non-small cell lung cancer cells.
      Title: CDK12 loss inhibits cell proliferation by regulating TBK1 in non-small cell lung cancer cells.
    Submit: New GeneRIF Correction See all GeneRIFs (66)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0904

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II CTD heptapeptide repeat kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of MAP kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin K-CDK12 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear cyclin-dependent protein kinase holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 12
    Names
    CDC2-related protein kinase 7
    Cdc2-related kinase, arginine/serine-rich
    cell division cycle 2-related protein kinase 7
    cell division protein kinase 12
    NP_055898.1
    NP_057591.2
    XP_005257513.1
    XP_011523195.1
    XP_011523196.1
    XP_011523197.1
    XP_011523199.1
    XP_011523200.1
    XP_011523208.1
    XP_011523209.1
    XP_016880242.1
    XP_047292209.1
    XP_047292211.1
    XP_047292212.1
    XP_047292213.1
    XP_047292214.1
    XP_047292215.1
    XP_047292216.1
    XP_047292217.1
    XP_047292218.1
    XP_047292219.1
    XP_047292220.1
    XP_047292221.1
    XP_047292222.1
    XP_047292223.1
    XP_047292224.1
    XP_047292225.1
    XP_047292226.1
    XP_047292228.1
    XP_047292229.1
    XP_047292230.1
    XP_047292231.1
    XP_047292232.1
    XP_047292233.1
    XP_047292234.1
    XP_047292235.1
    XP_047292236.1
    XP_047292237.1
    XP_047292238.1
    XP_047292239.1
    XP_047292240.1
    XP_047292241.1
    XP_047292242.1
    XP_047292243.1
    XP_047292244.1
    XP_047292245.1
    XP_047292246.1
    XP_047292247.1
    XP_047292248.1
    XP_047292249.1
    XP_054172424.1
    XP_054172425.1
    XP_054172426.1
    XP_054172427.1
    XP_054172428.1
    XP_054172429.1
    XP_054172430.1
    XP_054172431.1
    XP_054172432.1
    XP_054172433.1
    XP_054172434.1
    XP_054172435.1
    XP_054172436.1
    XP_054172437.1
    XP_054172438.1
    XP_054172439.1
    XP_054172440.1
    XP_054172441.1
    XP_054172442.1
    XP_054172443.1
    XP_054172444.1
    XP_054172445.1
    XP_054172446.1
    XP_054172447.1
    XP_054172448.1
    XP_054172449.1
    XP_054172450.1
    XP_054172451.1
    XP_054172452.1
    XP_054172453.1
    XP_054172454.1
    XP_054172455.1
    XP_054172456.1
    XP_054172457.1
    XP_054172458.1
    XP_054172459.1
    XP_054172460.1
    XP_054172461.1
    XP_054172462.1
    XP_054172463.1
    XP_054172464.1
    XP_054172465.1
    XP_054172466.1
    XP_054172467.1
    XP_054172468.1
    XP_054172469.1
    XP_054172470.1
    XP_054172471.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_065324.1 RefSeqGene

      Range
      5001..78059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1413

    mRNA and Protein(s)

    1. NM_015083.4 → NP_055898.1  cyclin-dependent kinase 12 isoform 2

      See identical proteins and their annotated locations for NP_055898.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC009283, AK302645, BC150265, BE003756, BM557102
      Consensus CDS
      CCDS45666.1
      UniProtKB/TrEMBL
      J3QSD7
      Related
      ENSP00000407720.2, ENST00000430627.6
      Conserved Domains (2) summary
      smart00220
      Location:727 → 1020
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:719 → 1020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    2. NM_016507.4 → NP_057591.2  cyclin-dependent kinase 12 isoform 1

      See identical proteins and their annotated locations for NP_057591.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.
      Source sequence(s)
      AC009283, AF227198, AK302645, BC150265, BE003756, BM557102
      Consensus CDS
      CCDS11337.1
      UniProtKB/Swiss-Prot
      A7E2B2, B4DYX4, B9EIQ6, O94978, Q9NYV4
      UniProtKB/TrEMBL
      J3QSD7
      Related
      ENSP00000398880.4, ENST00000447079.6
      Conserved Domains (2) summary
      smart00220
      Location:727 → 1020
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:719 → 1020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      39461486..39567559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436256.1 → XP_047292212.1  cyclin-dependent kinase 12 isoform X3

    2. XM_047436261.1 → XP_047292217.1  cyclin-dependent kinase 12 isoform X3

    3. XM_047436260.1 → XP_047292216.1  cyclin-dependent kinase 12 isoform X3

    4. XM_011524897.3 → XP_011523199.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523199.1

      UniProtKB/TrEMBL
      J3QSD7
      Conserved Domains (1) summary
      cd07864
      Location:719 → 1020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    5. XM_047436255.1 → XP_047292211.1  cyclin-dependent kinase 12 isoform X3

    6. XM_011524895.3 → XP_011523197.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523197.1

      UniProtKB/TrEMBL
      J3QSD7
      Conserved Domains (1) summary
      cd07864
      Location:719 → 1020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    7. XM_011524893.3 → XP_011523195.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523195.1

      UniProtKB/TrEMBL
      J3QSD7
      Conserved Domains (1) summary
      cd07864
      Location:719 → 1020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    8. XM_011524894.3 → XP_011523196.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523196.1

      UniProtKB/TrEMBL
      J3QSD7
      Conserved Domains (1) summary
      cd07864
      Location:719 → 1020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    9. XM_047436258.1 → XP_047292214.1  cyclin-dependent kinase 12 isoform X3

    10. XM_011524906.3 → XP_011523208.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523208.1

      UniProtKB/TrEMBL
      J3QSD7
      Conserved Domains (1) summary
      cd07864
      Location:719 → 1020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    11. XM_047436259.1 → XP_047292215.1  cyclin-dependent kinase 12 isoform X3

    12. XM_011524898.3 → XP_011523200.1  cyclin-dependent kinase 12 isoform X3

      See identical proteins and their annotated locations for XP_011523200.1

      UniProtKB/TrEMBL
      J3QSD7
      Conserved Domains (1) summary
      cd07864
      Location:719 → 1020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    13. XM_047436257.1 → XP_047292213.1  cyclin-dependent kinase 12 isoform X3

    14. XM_047436278.1 → XP_047292234.1  cyclin-dependent kinase 12 isoform X5

    15. XM_047436267.1 → XP_047292223.1  cyclin-dependent kinase 12 isoform X5

    16. XM_047436277.1 → XP_047292233.1  cyclin-dependent kinase 12 isoform X5

    17. XM_047436268.1 → XP_047292224.1  cyclin-dependent kinase 12 isoform X5

    18. XM_047436265.1 → XP_047292221.1  cyclin-dependent kinase 12 isoform X5

    19. XM_047436266.1 → XP_047292222.1  cyclin-dependent kinase 12 isoform X5

    20. XM_047436270.1 → XP_047292226.1  cyclin-dependent kinase 12 isoform X5

    21. XM_047436273.1 → XP_047292229.1  cyclin-dependent kinase 12 isoform X5

    22. XM_047436275.1 → XP_047292231.1  cyclin-dependent kinase 12 isoform X5

    23. XM_047436276.1 → XP_047292232.1  cyclin-dependent kinase 12 isoform X5

    24. XM_047436274.1 → XP_047292230.1  cyclin-dependent kinase 12 isoform X5

    25. XM_047436279.1 → XP_047292235.1  cyclin-dependent kinase 12 isoform X5

    26. XM_047436269.1 → XP_047292225.1  cyclin-dependent kinase 12 isoform X5

    27. XM_047436272.1 → XP_047292228.1  cyclin-dependent kinase 12 isoform X5

    28. XM_011524907.3 → XP_011523209.1  cyclin-dependent kinase 12 isoform X7

      UniProtKB/TrEMBL
      H0YLT2, J3QSD7
      Related
      ENSP00000453329.2, ENST00000559663.2
      Conserved Domains (2) summary
      smart00220
      Location:727 → 1020
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:719 → 1020
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    29. XM_047436287.1 → XP_047292243.1  cyclin-dependent kinase 12 isoform X7

      UniProtKB/TrEMBL
      H0YLT2

    30. XM_047436288.1 → XP_047292244.1  cyclin-dependent kinase 12 isoform X7

      UniProtKB/TrEMBL
      H0YLT2

    31. XM_047436289.1 → XP_047292245.1  cyclin-dependent kinase 12 isoform X7

      UniProtKB/TrEMBL
      H0YLT2

    32. XM_047436293.1 → XP_047292249.1  cyclin-dependent kinase 12 isoform X9

    33. XM_047436262.1 → XP_047292218.1  cyclin-dependent kinase 12 isoform X4

    34. XM_047436264.1 → XP_047292220.1  cyclin-dependent kinase 12 isoform X4

    35. XM_047436263.1 → XP_047292219.1  cyclin-dependent kinase 12 isoform X4

    36. XM_047436282.1 → XP_047292238.1  cyclin-dependent kinase 12 isoform X6

    37. XM_047436283.1 → XP_047292239.1  cyclin-dependent kinase 12 isoform X6

    38. XM_047436280.1 → XP_047292236.1  cyclin-dependent kinase 12 isoform X6

    39. XM_047436281.1 → XP_047292237.1  cyclin-dependent kinase 12 isoform X6

    40. XM_047436284.1 → XP_047292240.1  cyclin-dependent kinase 12 isoform X6

    41. XM_047436285.1 → XP_047292241.1  cyclin-dependent kinase 12 isoform X6

    42. XM_047436286.1 → XP_047292242.1  cyclin-dependent kinase 12 isoform X6

    43. XM_047436290.1 → XP_047292246.1  cyclin-dependent kinase 12 isoform X8

    44. XM_017024753.3 → XP_016880242.1  cyclin-dependent kinase 12 isoform X8

      UniProtKB/TrEMBL
      J3QSD7

    45. XM_047436292.1 → XP_047292248.1  cyclin-dependent kinase 12 isoform X8

    46. XM_047436291.1 → XP_047292247.1  cyclin-dependent kinase 12 isoform X8

      Related
      ENSP00000464641.1, ENST00000584632.5

    47. XM_005257456.5 → XP_005257513.1  cyclin-dependent kinase 12 isoform X1

      UniProtKB/TrEMBL
      J3QSD7
      Conserved Domains (2) summary
      smart00220
      Location:726 → 1019
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07864
      Location:718 → 1019
      STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

    48. XM_047436253.1 → XP_047292209.1  cyclin-dependent kinase 12 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      40325392..40431128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316455.1 → XP_054172430.1  cyclin-dependent kinase 12 isoform X3

    2. XM_054316463.1 → XP_054172438.1  cyclin-dependent kinase 12 isoform X3

    3. XM_054316462.1 → XP_054172437.1  cyclin-dependent kinase 12 isoform X3

    4. XM_054316454.1 → XP_054172429.1  cyclin-dependent kinase 12 isoform X3

    5. XM_054316453.1 → XP_054172428.1  cyclin-dependent kinase 12 isoform X3

    6. XM_054316458.1 → XP_054172433.1  cyclin-dependent kinase 12 isoform X3

    7. XM_054316451.1 → XP_054172426.1  cyclin-dependent kinase 12 isoform X3

    8. XM_054316452.1 → XP_054172427.1  cyclin-dependent kinase 12 isoform X3

    9. XM_054316459.1 → XP_054172434.1  cyclin-dependent kinase 12 isoform X3

    10. XM_054316457.1 → XP_054172432.1  cyclin-dependent kinase 12 isoform X3

    11. XM_054316460.1 → XP_054172435.1  cyclin-dependent kinase 12 isoform X3

    12. XM_054316461.1 → XP_054172436.1  cyclin-dependent kinase 12 isoform X3

    13. XM_054316456.1 → XP_054172431.1  cyclin-dependent kinase 12 isoform X3

    14. XM_054316479.1 → XP_054172454.1  cyclin-dependent kinase 12 isoform X5

    15. XM_054316469.1 → XP_054172444.1  cyclin-dependent kinase 12 isoform X5

    16. XM_054316478.1 → XP_054172453.1  cyclin-dependent kinase 12 isoform X5

    17. XM_054316470.1 → XP_054172445.1  cyclin-dependent kinase 12 isoform X5

    18. XM_054316467.1 → XP_054172442.1  cyclin-dependent kinase 12 isoform X5

    19. XM_054316468.1 → XP_054172443.1  cyclin-dependent kinase 12 isoform X5

    20. XM_054316472.1 → XP_054172447.1  cyclin-dependent kinase 12 isoform X5

    21. XM_054316474.1 → XP_054172449.1  cyclin-dependent kinase 12 isoform X5

    22. XM_054316476.1 → XP_054172451.1  cyclin-dependent kinase 12 isoform X5

    23. XM_054316477.1 → XP_054172452.1  cyclin-dependent kinase 12 isoform X5

    24. XM_054316475.1 → XP_054172450.1  cyclin-dependent kinase 12 isoform X5

    25. XM_054316480.1 → XP_054172455.1  cyclin-dependent kinase 12 isoform X5

    26. XM_054316471.1 → XP_054172446.1  cyclin-dependent kinase 12 isoform X5

    27. XM_054316473.1 → XP_054172448.1  cyclin-dependent kinase 12 isoform X5

    28. XM_054316489.1 → XP_054172464.1  cyclin-dependent kinase 12 isoform X7

      UniProtKB/TrEMBL
      H0YLT2

    29. XM_054316488.1 → XP_054172463.1  cyclin-dependent kinase 12 isoform X7

      UniProtKB/TrEMBL
      H0YLT2

    30. XM_054316490.1 → XP_054172465.1  cyclin-dependent kinase 12 isoform X7

      UniProtKB/TrEMBL
      H0YLT2

    31. XM_054316491.1 → XP_054172466.1  cyclin-dependent kinase 12 isoform X7

      UniProtKB/TrEMBL
      H0YLT2

    32. XM_054316496.1 → XP_054172471.1  cyclin-dependent kinase 12 isoform X9

    33. XM_054316464.1 → XP_054172439.1  cyclin-dependent kinase 12 isoform X4

    34. XM_054316466.1 → XP_054172441.1  cyclin-dependent kinase 12 isoform X4

    35. XM_054316465.1 → XP_054172440.1  cyclin-dependent kinase 12 isoform X4

    36. XM_054316483.1 → XP_054172458.1  cyclin-dependent kinase 12 isoform X6

    37. XM_054316484.1 → XP_054172459.1  cyclin-dependent kinase 12 isoform X6

    38. XM_054316481.1 → XP_054172456.1  cyclin-dependent kinase 12 isoform X6

    39. XM_054316482.1 → XP_054172457.1  cyclin-dependent kinase 12 isoform X6

    40. XM_054316485.1 → XP_054172460.1  cyclin-dependent kinase 12 isoform X6

    41. XM_054316486.1 → XP_054172461.1  cyclin-dependent kinase 12 isoform X6

    42. XM_054316487.1 → XP_054172462.1  cyclin-dependent kinase 12 isoform X6

    43. XM_054316492.1 → XP_054172467.1  cyclin-dependent kinase 12 isoform X8

    44. XM_054316493.1 → XP_054172468.1  cyclin-dependent kinase 12 isoform X8

    45. XM_054316495.1 → XP_054172470.1  cyclin-dependent kinase 12 isoform X8

    46. XM_054316494.1 → XP_054172469.1  cyclin-dependent kinase 12 isoform X8

    47. XM_054316449.1 → XP_054172424.1  cyclin-dependent kinase 12 isoform X1

    48. XM_054316450.1 → XP_054172425.1  cyclin-dependent kinase 12 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NYV4.2 GenPept UniProtKB/Swiss-Prot:Q9NYV4

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