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    EFT1 elongation factor 2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854301, updated on 2-Nov-2024

    Summary

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    Official Symbol
    EFT1
    Official Full Name
    elongation factor 2
    Primary source
    SGD:S000005659
    Locus tag
    YOR133W
    See related
    AllianceGenome:SGD:S000005659; FungiDB:YOR133W; VEuPathDB:YOR133W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity; protein-folding chaperone binding activity; and ribosome binding activity. Involved in maintenance of translational fidelity; positive regulation of translational elongation; and translational elongation. Located in cytosol. Human ortholog(s) of this gene implicated in glaucoma; spinocerebellar ataxia type 26; and stomach cancer. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See EFT1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (575098..577626)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative haloacid dehalogenase-like hydrolase Neighboring gene retromer subunit VPS17 Neighboring gene GTPase-activating protein BAG7 Neighboring gene isocitrate dehydrogenase (NAD(+)) IDH2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthetic labeling of diphthamide in Saccharomyces cerevisiae. Dunlop PC, et al. J Biol Chem, 1983 Apr 25. PMID 6339504
    2. Elongation factor 2 mutants deficient in diphthamide formation show temperature-sensitive cell growth. Kimata Y, et al. J Biol Chem, 1994 May 6. PMID 8175783
    3. Expression of non-ADP-ribosylatable, diphtheria toxin-resistant elongation factor 2 in Saccharomyces cerevisiae. Kimata Y, et al. Biochem Biophys Res Commun, 1993 Mar 31. PMID 8466491
    4. Saccharomyces cerevisiae elongation factor 2. Mutagenesis of the histidine precursor of diphthamide yields a functional protein that is resistant to diphtheria toxin. Phan LD, et al. J Biol Chem, 1993 Apr 25. PMID 8473309
    5. Ty1 retrotransposition and programmed +1 ribosomal frameshifting require the integrity of the protein synthetic translocation step. Harger JW, et al. Virology, 2001 Jul 20. PMID 11448174

    See all (125) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maintenance of translational fidelity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translational elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    elongation factor 2
    NP_014776.1
    • Elongation factor 2 (eEF2, EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      575098..577626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183552.1 → NP_014776.1  TPA: elongation factor 2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014776.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT19, P32324, Q6JEF7
      UniProtKB/TrEMBL
      A6ZNY0, B3LFR5, B5VGR2, C7GN88, C8Z5U9, G2WN08, N1P7B9
      Conserved Domains (1) summary
      PTZ00416
      Location:1 → 842
      PTZ00416; elongation factor 2; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32324.1

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