mtdha metadherin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mtdhaprovided by ZNC
Official Full Name: metadherin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-615
See related: Ensembl:ENSDARG00000014159 AllianceGenome:ZFIN:ZDB-GENE-030616-615
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lyric; lyricl; wu:fc33g06; si:zc215i13.6
Summary: Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of angiogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MTDH (metadherin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (32895379..32914231, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (33308259..33327180, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj49d06.x1 (e-PCR)
- UniSTS:199450

fc22c12.y1 (e-PCR)
- UniSTS:193089

fc33g06.x1 (e-PCR)
- UniSTS:188017

fd17e01.y1 (e-PCR)
- UniSTS:195224

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: metadherin a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007135.2 → NP_001007136.2 metadherin a

See identical proteins and their annotated locations for NP_001007136.2

Status: PROVISIONAL

Source sequence(s)

BC068430

UniProtKB/TrEMBL

Q6NUU0

Related

ENSDARP00000147602.1, ENSDART00000186115.1

Conserved Domains (1) summary

pfam15686
Location:5 → 445

LYRIC; Lysine-rich CEACAM1 co-isolated protein family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

32895379..32914231 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159603.4 → XP_005159660.1 metadherin a isoform X2

UniProtKB/TrEMBL

A0A8M2B6D6, A8DZ70, E7EZ81

Related

ENSDARP00000111658.2, ENSDART00000124246.4

Conserved Domains (1) summary

pfam15686
Location:5 → 446

LYRIC; Lysine-rich CEACAM1 co-isolated protein family
XM_005159604.4 → XP_005159661.1 metadherin a isoform X3

UniProtKB/TrEMBL

A0A2R8QJH1, A0A8M2B6A1

Conserved Domains (1) summary

pfam15686
Location:5 → 446

LYRIC; Lysine-rich CEACAM1 co-isolated protein family
XM_017352195.3 → XP_017207684.1 metadherin a isoform X1

UniProtKB/TrEMBL

A0A8M6YWB0