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    emsy EMSY transcriptional repressor, BRCA2 interacting [ Danio rerio (zebrafish) ]

    Gene ID: 335889, updated on 17-Sep-2024

    Summary

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    Official Symbol
    emsyprovided by ZNC
    Official Full Name
    EMSY transcriptional repressor, BRCA2 interactingprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7832
    See related
    Ensembl:ENSDARG00000059059 AllianceGenome:ZFIN:ZDB-GENE-030131-7832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj36b04; zgc:56039; wu:fj36b04
    Summary
    Predicted to act upstream of or within DNA repair; chromatin organization; and regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human EMSY (EMSY transcriptional repressor, BRCA2 interacting). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See emsy in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (282770..302831, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (284186..302919, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene kelch-like family member 35 Neighboring gene leucine rich repeat containing 32 Neighboring gene wu:fj39h09 Neighboring gene v-akt murine thymoma viral oncogene homolog 2, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BRCA2-interacting transcriptional repressor EMSY
    Names
    EMSY BRCA2-interacting transcriptional repressor
    protein EMSY

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199984.2 → NP_956278.2  BRCA2-interacting transcriptional repressor EMSY

      Status: VALIDATED

      Source sequence(s)
      CABZ01049608, CU469093
      UniProtKB/Swiss-Prot
      Q7ZUV7
      UniProtKB/TrEMBL
      B2GRX8
      Related
      ENSDARP00000138672.2, ENSDART00000157582.2

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      282770..302831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009305037.4 → XP_009303312.1  BRCA2-interacting transcriptional repressor EMSY isoform X1

      See identical proteins and their annotated locations for XP_009303312.1

      UniProtKB/Swiss-Prot
      Q7ZUV7
      UniProtKB/TrEMBL
      A0A8M3B5X7, B2GRX8
      Conserved Domains (1) summary
      pfam03735
      Location:30 → 96
      ENT; ENT domain

    2. XM_009305041.4 → XP_009303316.1  BRCA2-interacting transcriptional repressor EMSY isoform X5

      UniProtKB/Swiss-Prot
      Q7ZUV7
      UniProtKB/TrEMBL
      A0A8M3AWD8, B2GRX8
      Conserved Domains (1) summary
      pfam03735
      Location:30 → 96
      ENT; ENT domain

    3. XM_068223730.1 → XP_068079831.1  BRCA2-interacting transcriptional repressor EMSY isoform X4

    4. XM_009305040.4 → XP_009303315.1  BRCA2-interacting transcriptional repressor EMSY isoform X3

      UniProtKB/Swiss-Prot
      Q7ZUV7
      UniProtKB/TrEMBL
      A0A8M3BCQ8, B2GRX8
      Conserved Domains (2) summary
      pfam03735
      Location:30 → 96
      ENT; ENT domain
      pfam05109
      Location:300 → 759
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    5. XM_009305039.4 → XP_009303314.1  BRCA2-interacting transcriptional repressor EMSY isoform X2

      UniProtKB/Swiss-Prot
      Q7ZUV7
      UniProtKB/TrEMBL
      A0A8M3AWE9, B2GRX8
      Conserved Domains (1) summary
      pfam03735
      Location:30 → 96
      ENT; ENT domain

    6. XM_009305036.4 → XP_009303311.1  BRCA2-interacting transcriptional repressor EMSY isoform X1

      See identical proteins and their annotated locations for XP_009303311.1

      UniProtKB/Swiss-Prot
      Q7ZUV7
      UniProtKB/TrEMBL
      A0A8M3B5X7, B2GRX8
      Conserved Domains (1) summary
      pfam03735
      Location:30 → 96
      ENT; ENT domain

    7. XM_068223729.1 → XP_068079830.1  BRCA2-interacting transcriptional repressor EMSY isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZUV7.1 GenPept UniProtKB/Swiss-Prot:Q7ZUV7

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