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    lin-29 C2H2-type domain-containing protein;Zinc finger transcription factor lin-29 [ Caenorhabditis elegans ]

    Gene ID: 174830, updated on 2-Nov-2024

    Summary

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    Official Symbol
    lin-29
    Official Full Name
    C2H2-type domain-containing protein;Zinc finger transcription factor lin-29
    Primary source
    WormBase:WBGene00003015
    Locus tag
    CELE_W03C9.4
    See related
    AllianceGenome:WB:WBGene00003015
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including collagen biosynthetic process; regulation of gene expression; and regulation of nematode larval development. Located in nucleus. Is expressed in several structures, including R2_hyp; gonad; hypodermis; neurons; and proctodeal cell. Orthologous to human ZNF362 (zinc finger protein 362). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See lin-29 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (11917643..11935340, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene non-specific serine/threonine protein kinase Neighboring gene RGS domain-containing protein Neighboring gene High mobility group protein hmg-12 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities. Narasimhan K, et al. Elife, 2015 Apr 23. PMID 25905672, Free PMC Article
    2. Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development. Wightman B, et al. Genes Dev, 1991 Oct. PMID 1916264
    3. Rejuvenating nerve cells in adults. Chiu H, et al. Aging (Albany NY), 2013 Jul. PMID 23852222, Free PMC Article
    4. The C. elegans gene pan-1 encodes novel transmembrane and cytoplasmic leucine-rich repeat proteins and promotes molting and the larva to adult transition. Gissendanner CR, et al. BMC Dev Biol, 2013 May 17. PMID 23682709, Free PMC Article
    5. Heterochronic control of AFF-1-mediated cell-to-cell fusion in C. elegans. Friedlander-Shani L, et al. Adv Exp Med Biol, 2011. PMID 21432011

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms.
      Title: A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms.
    2. New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans.
      Title: New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans.
    3. MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans.
      Title: MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in collagen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vitellogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in programmed cell death involved in cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of basement membrane organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of development, heterochronic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nematode larval development, heterochronic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C2H2-type domain-containing protein;Zinc finger transcription factor lin-29
    NP_001122649.1
    • Confirmed by transcript evidence
    NP_001254324.1
    • Confirmed by transcript evidence
    NP_001391103.1
    • Confirmed by transcript evidence
    NP_001407498.1
    • Confirmed by transcript evidence
    NP_001407499.1
    • Confirmed by transcript evidence
    NP_001407500.1
    • Confirmed by transcript evidence
    NP_001407501.1
    • Confirmed by transcript evidence
    NP_001407502.1
    • Confirmed by transcript evidence
    NP_001407503.1
    • Confirmed by transcript evidence
    NP_001407504.1
    • Confirmed by transcript evidence
    NP_001407505.1
    • Confirmed by transcript evidence
    NP_001407506.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11917643..11935340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001404245.1 → NP_001391103.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QGF3

    2. NM_001129177.4 → NP_001122649.1  Zinc finger transcription factor lin-29 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E6N0V9, G5EGB2, G5EGU6
      Conserved Domains (4) summary
      sd00017
      Location:149 → 169
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:178 → 198
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:190 → 217
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:177 → 261
      zf-C2H2_8; C2H2-type zinc ribbon

    3. NM_001420596.1 → NP_001407498.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4Q999

    4. NM_001420597.1 → NP_001407500.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QF14

    5. NM_001420598.1 → NP_001407502.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QBR1

    6. NM_001420599.1 → NP_001407499.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QAV3

    7. NM_001420600.1 → NP_001407501.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QD13

    8. NM_001420601.1 → NP_001407503.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QB12

    9. NM_001420602.1 → NP_001407504.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QF65

    10. NM_001267395.3 → NP_001254324.1  Zinc finger transcription factor lin-29 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254324.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E6N0V9
      Conserved Domains (4) summary
      sd00017
      Location:11 → 31
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:40 → 60
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:52 → 79
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:39 → 123
      zf-C2H2_8; C2H2-type zinc ribbon

    11. NM_001420603.1 → NP_001407505.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QD26

    12. NM_001420604.1 → NP_001407506.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QBS8
    Nucleotide Protein
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