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    Ncoa7 nuclear receptor coactivator 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498995, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Ncoa7provided by RGD
    Official Full Name
    nuclear receptor coactivator 7provided by RGD
    Primary source
    RGD:1566426
    See related
    EnsemblRapid:ENSRNOG00000014004 AllianceGenome:RGD:1566426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566426
    Summary
    Predicted to enable nuclear receptor binding activity and nuclear receptor coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and response to oxidative stress. Predicted to act upstream of or within negative regulation of cellular response to oxidative stress; negative regulation of oxidative stress-induced neuron death; and negative regulation of peptidyl-cysteine S-nitrosylation. Predicted to be active in nucleus. Orthologous to human NCOA7 (nuclear receptor coactivator 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 261.8), Brain (RPKM 105.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ncoa7 in Genome Data Viewer
    Location:
    1p11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (28674614..28835891)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (26856228..27016950)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (29225727..29386642)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene hes-related family bHLH transcription factor with YRPW motif 2 Neighboring gene transfer RNA glutamic acid (anticodon CUC) 1 Neighboring gene histidine triad nucleotide binding protein 3 Neighboring gene tRNA methyltransferase 11 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ERAP140, a conserved tissue-specific nuclear receptor coactivator. Shao W, et al. Mol Cell Biol, 2002 May. PMID 11971969, Free PMC Article
    2. The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress. Finelli MJ, et al. J Biol Chem, 2016 Feb 5. PMID 26668325, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidyl-cysteine S-nitrosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor coactivator 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432412.1 → NP_001419341.1  nuclear receptor coactivator 7 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    2. NM_001432413.1 → NP_001419342.1  nuclear receptor coactivator 7 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    3. NM_001432414.1 → NP_001419343.1  nuclear receptor coactivator 7 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    4. NM_001432415.1 → NP_001419344.1  nuclear receptor coactivator 7 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      28674614..28835891
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276554.1 → XP_063132624.1  nuclear receptor coactivator 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I5XVX5, F1LWN1

    2. XM_063276558.1 → XP_063132628.1  nuclear receptor coactivator 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A0R1

    3. XM_063276541.1 → XP_063132611.1  nuclear receptor coactivator 7 isoform X1

      UniProtKB/TrEMBL
      F1LWN1

    4. XM_039099278.2 → XP_038955206.1  nuclear receptor coactivator 7 isoform X1

      UniProtKB/TrEMBL
      F1LWN1
      Conserved Domains (2) summary
      smart00584
      Location:815 → 977
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:149 → 191
      LysM; LysM domain

    5. XM_039099281.2 → XP_038955209.1  nuclear receptor coactivator 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A0R1
      Related
      ENSRNOP00000077233.2, ENSRNOT00000097027.2
      Conserved Domains (2) summary
      smart00584
      Location:804 → 966
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:149 → 191
      LysM; LysM domain

    6. XM_006227758.5 → XP_006227820.1  nuclear receptor coactivator 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I5XVX5, F1LWN1
      Related
      ENSRNOP00000099439.1, ENSRNOT00000150078.1
      Conserved Domains (2) summary
      smart00584
      Location:783 → 945
      TLDc; domain in TBC and LysM domain containing proteins
      pfam01476
      Location:117 → 159
      LysM; LysM domain

    7. XM_063276557.1 → XP_063132627.1  nuclear receptor coactivator 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A0R1
      Related
      ENSRNOP00000084173.1, ENSRNOT00000098212.2

    8. XM_063276551.1 → XP_063132621.1  nuclear receptor coactivator 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I5XVX5, F1LWN1

    9. XM_063276544.1 → XP_063132614.1  nuclear receptor coactivator 7 isoform X1

      UniProtKB/TrEMBL
      F1LWN1

    10. XM_006227760.5 → XP_006227822.1  nuclear receptor coactivator 7 isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y5Q5, A6JUS3
      Related
      ENSRNOP00000101437.1, ENSRNOT00000159673.1
      Conserved Domains (1) summary
      smart00584
      Location:59 → 221
      TLDc; domain in TBC and LysM domain containing proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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