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    UPS3 Ups3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851766, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UPS3
    Official Full Name
    Ups3p
    Primary source
    SGD:S000002593
    Locus tag
    YDR185C
    See related
    AllianceGenome:SGD:S000002593; FungiDB:YDR185C; VEuPathDB:YDR185C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GEP2
    Summary
    Predicted to enable phosphatidic acid transfer activity. Involved in mitochondrion morphogenesis. Located in mitochondrial intermembrane space. Is extrinsic component of mitochondrial inner membrane. Orthologous to human PRELID3A (PRELI domain containing 3A) and PRELID3B (PRELI domain containing 3B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UPS3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (831934..832473, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Plp1p Neighboring gene Atc1p Neighboring gene Snd1p Neighboring gene chaperonin-containing T-complex subunit CCT6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct functions of evolutionary conserved MSF1 and late embryogenesis abundant (LEA)-like domains in mitochondria. Hall BM, et al. J Biol Chem, 2011 Nov 11. PMID 21930701, Free PMC Article
    2. Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p. Sesaki H, et al. J Cell Biol, 2006 Jun 5. PMID 16754953, Free PMC Article
    3. Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation. Tamura Y, et al. EMBO J, 2010 Sep 1. PMID 20622808, Free PMC Article
    4. The GOLD domain, a novel protein module involved in Golgi function and secretion. Anantharaman V, et al. Genome Biol, 2002. PMID 12049664, Free PMC Article
    5. Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria. Tamura Y, et al. J Cell Biol, 2009 Jun 15. PMID 19506038, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors show that Ups1, Ups2 and Ups3 protein import is mediated by another mitochondrial intermembrane space protein, Mdm35p.
      Title: Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphatidic acid transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ups3p
    NP_010471.1
    • Mitochondrial hypothetical protein; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations; UPS3 has a paralog, UPS2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      831934..832473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180493.1 → NP_010471.1  TPA: Ups3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010471.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSG9, Q04006
      UniProtKB/TrEMBL
      A6ZYE5, B3LG96, B5VG79, C7GN11, C8Z5A0, G2WAT5, N1P6H9
      Conserved Domains (1) summary
      pfam04707
      Location:15 → 171
      PRELI; PRELI-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04006.1

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