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    FCRLA Fc receptor like A [ Homo sapiens (human) ]

    Gene ID: 84824, updated on 28-Oct-2024

    Summary

    Official Symbol
    FCRLAprovided by HGNC
    Official Full Name
    Fc receptor like Aprovided by HGNC
    Primary source
    HGNC:HGNC:18504
    See related
    Ensembl:ENSG00000132185 MIM:606891; AllianceGenome:HGNC:18504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FCRL; FCRX; FREB; FCRL1; FCRLX; FCRLb; FCRLd; FCRLe; FCRLM1; FCRLc1; FCRLc2
    Summary
    This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
    Expression
    Biased expression in lymph node (RPKM 32.1), spleen (RPKM 21.2) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FCRLA in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161707229..161714352)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (161051554..161058676)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161677019..161684142)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1483 Neighboring gene Fc gamma receptor IIb Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161640790-161641368 Neighboring gene ribosomal protein L31 pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1999 Neighboring gene Fc receptor like B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2000 Neighboring gene RNA, 7SL, cytoplasmic 466, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC4595

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Fc receptor-like A
    Names
    Fc receptor homolog expressed in B cells (FREB)
    Fc receptor related protein X
    Fc receptor-like and mucin-like 1
    fc receptor homolog expressed in B-cells
    fc receptor-like and mucin-like protein 1
    fc receptor-like protein
    fc receptor-related protein X

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001184866.2NP_001171795.2  Fc receptor-like A isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1). This variant has also been called FCRLa1.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS53415.2
      Related
      ENSP00000356930.3, ENST00000367953.7
      Conserved Domains (2) summary
      pfam13895
      Location:177266
      Ig_2; Immunoglobulin domain
      cl11960
      Location:85152
      Ig; Immunoglobulin domain
    2. NM_001184867.2NP_001171796.2  Fc receptor-like A isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1. This variant has also been called FCRLb.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS53417.2
      Related
      ENSP00000439838.1, ENST00000546024.5
      Conserved Domains (1) summary
      pfam13895
      Location:82171
      Ig_2; Immunoglobulin domain
    3. NM_001184870.2NP_001171799.2  Fc receptor-like A isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1. This variant has also been called FCRLc1.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS53416.2
      Related
      ENSP00000442870.1, ENST00000540521.5
      Conserved Domains (1) summary
      pfam13895
      Location:37126
      Ig_2; Immunoglobulin domain
    4. NM_001184871.2NP_001171800.2  Fc receptor-like A isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks four alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 7) is shorter when it is compared to isoform 1. This variant has also been called FCRLe.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS53420.1
      Related
      ENSP00000344808.3, ENST00000350710.3
    5. NM_001184872.2NP_001171801.2  Fc receptor-like A isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks three alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1. This variant has also been called FCRLc2.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS53419.2
      Related
      ENSP00000356934.3, ENST00000367957.7
      Conserved Domains (1) summary
      pfam13895
      Location:31120
      Ig_2; Immunoglobulin domain
    6. NM_001184873.2NP_001171802.2  Fc receptor-like A isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks three alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 6) is shorter when it is compared to isoform 1. This variant has also been called FCRLd.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS53418.1
      UniProtKB/TrEMBL
      Q5VXA5
      Related
      ENSP00000356926.2, ENST00000367949.6
    7. NM_001366195.2NP_001353124.2  Fc receptor-like A isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL359541
      Conserved Domains (2) summary
      pfam13895
      Location:176265
      Ig_2; Immunoglobulin domain
      cl11960
      Location:84151
      Ig; Immunoglobulin domain
    8. NM_001366196.2NP_001353125.2  Fc receptor-like A isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS91091.1
      Related
      ENSP00000294798.7, ENST00000349527.8
      Conserved Domains (1) summary
      cl11960
      Location:79146
      Ig; Immunoglobulin domain
    9. NM_032738.4NP_116127.4  Fc receptor-like A isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame segment, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. This variant has also been called FCRLa.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS30926.2
      UniProtKB/Swiss-Prot
      A0N0M1, A6NC03, A6NL20, F5H720, F8W743, G3V1J2, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXA4, Q5VXB0, Q5VXB1, Q7L513, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57
      Related
      ENSP00000236938.7, ENST00000236938.12
      Conserved Domains (2) summary
      pfam13895
      Location:171260
      Ig_2; Immunoglobulin domain
      cl11960
      Location:79146
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      161707229..161714352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510065.2XP_011508367.2  Fc receptor-like A isoform X2

    2. XM_006711581.4XP_006711644.2  Fc receptor-like A isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      161051554..161058676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339259.1XP_054195234.1  Fc receptor-like A isoform X2

    2. XM_054339258.1XP_054195233.1  Fc receptor-like A isoform X1