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    OR1J2 olfactory receptor family 1 subfamily J member 2 [ Homo sapiens (human) ]

    Gene ID: 26740, updated on 28-Oct-2024

    Summary

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    Official Symbol
    OR1J2provided by HGNC
    Official Full Name
    olfactory receptor family 1 subfamily J member 2provided by HGNC
    Primary source
    HGNC:HGNC:8209
    See related
    Ensembl:ENSG00000197233 AllianceGenome:HGNC:8209
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSA5; HG152; OR1J3; OR1J5; OR9-19; OST044
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See OR1J2 in Genome Data Viewer
    Location:
    9q33.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (122447433..122580427)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (134644883..134777736)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125273081..125274022)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:125137981-125138948 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:125145815-125147014 Neighboring gene prostaglandin-endoperoxide synthase 1 Neighboring gene uncharacterized LOC124902264 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:125164273-125165472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:125226029-125226530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20241 Neighboring gene olfactory receptor family 1 subfamily J member 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:125299684-125300883 Neighboring gene olfactory receptor family 1 subfamily J member 4 Neighboring gene olfactory receptor family 1 subfamily N member 1 Neighboring gene olfactory receptor family 1 subfamily L member 8 Neighboring gene olfactory receptor family 1 subfamily N member 2 Neighboring gene uncharacterized LOC124902265 Neighboring gene olfactory receptor family 1 subfamily H member 1 pseudogene Neighboring gene olfactory receptor family 1 subfamily Q member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Natural selection on the olfactory receptor gene family in humans and chimpanzees. Gilad Y, et al. Am J Hum Genet, 2003 Sep. PMID 12908129, Free PMC Article
    2. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Parmentier M, et al. Nature, 1992 Jan 30. PMID 1370859
    3. The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates. Rouquier S, et al. Proc Natl Acad Sci U S A, 2000 Mar 14. PMID 10706615, Free PMC Article
    4. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
    5. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16828

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 1J2
    Names
    HTPCRX15
    olfactory receptor 1J3
    olfactory receptor 1J5
    olfactory receptor OR9-19
    olfactory receptor, family 1, subfamily J, member 3
    olfactory receptor, family 1, subfamily J, member 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054107.1 → NP_473448.1  olfactory receptor 1J2

      See identical proteins and their annotated locations for NP_473448.1

      Status: PROVISIONAL

      Source sequence(s)
      AL359636
      Consensus CDS
      CCDS35121.1
      UniProtKB/Swiss-Prot
      A3KFL9, Q6IF14, Q8NGS2, Q96R90, Q9NZP1
      UniProtKB/TrEMBL
      A0A126GW18, B3KVN8
      Related
      ENSP00000335575.5, ENST00000335302.5
      Conserved Domains (1) summary
      cd15918
      Location:26 → 294
      7tmA_OR1_7-like; olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      122447433..122580427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447517.2 → XP_024303285.1  olfactory receptor 1J2 isoform X1

      UniProtKB/Swiss-Prot
      A3KFL9, Q6IF14, Q8NGS2, Q96R90, Q9NZP1
      UniProtKB/TrEMBL
      A0A126GW18, B3KVN8
      Conserved Domains (1) summary
      cd15918
      Location:26 → 294
      7tmA_OR1_7-like; olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_024447516.2 → XP_024303284.1  olfactory receptor 1J2 isoform X1

      UniProtKB/Swiss-Prot
      A3KFL9, Q6IF14, Q8NGS2, Q96R90, Q9NZP1
      UniProtKB/TrEMBL
      A0A126GW18, B3KVN8
      Conserved Domains (1) summary
      cd15918
      Location:26 → 294
      7tmA_OR1_7-like; olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RNA

    1. XR_007061274.1 RNA Sequence

    2. XR_007061272.1 RNA Sequence

    3. XR_007061273.1 RNA Sequence

    4. XR_007061276.1 RNA Sequence

    5. XR_007061275.1 RNA Sequence

    6. XR_007061271.1 RNA Sequence

    7. XR_007061277.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      134644883..134777736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362741.1 → XP_054218716.1  olfactory receptor 1J2 isoform X1

      UniProtKB/Swiss-Prot
      A3KFL9, Q6IF14, Q8NGS2, Q96R90, Q9NZP1
      UniProtKB/TrEMBL
      A0A126GW18

    2. XM_054362740.1 → XP_054218715.1  olfactory receptor 1J2 isoform X1

      UniProtKB/Swiss-Prot
      A3KFL9, Q6IF14, Q8NGS2, Q96R90, Q9NZP1
      UniProtKB/TrEMBL
      A0A126GW18

    RNA

    1. XR_007079987.1 RNA Sequence

    2. XR_007079988.1 RNA Sequence

    3. XR_007079990.1 RNA Sequence

    4. XR_007079989.1 RNA Sequence

    5. XR_007079986.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NGS2.1 GenPept UniProtKB/Swiss-Prot:Q8NGS2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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