gmps-1 putative GMP synthase [glutamine-hydrolyzing] [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gmps-1
Official Full Name: putative GMP synthase [glutamine-hydrolyzing]
Primary source: WormBase:WBGene00010912
Locus tag: CELE_M106.4
See related: AllianceGenome:WB:WBGene00010912
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GMP synthase activity. Predicted to be involved in GMP biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human GMPS (guanine monophosphate synthase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gmps-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (10863679..10868720, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M106.5 (e-PCR)
- UniSTS:307818

M106.4 (e-PCR)
- UniSTS:311991

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GMP synthase (glutamine-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info
enables GMP synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative GMP synthase [glutamine-hydrolyzing]

NP_001022256.2

Confirmed by transcript evidence

NP_001022257.2

Confirmed by transcript evidence

NP_001076631.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10863679..10868720 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027085.4 → NP_001022256.2 putative GMP synthase [glutamine-hydrolyzing] [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022256.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09580

Conserved Domains (3) summary

cd01742
Location:59 → 241

GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase

PRK00074
Location:57 → 609

guaA; GMP synthase; Reviewed

cd01997
Location:272 → 742

GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...
NM_001027086.6 → NP_001022257.2 putative GMP synthase [glutamine-hydrolyzing] [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022257.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09580, Q0G842, Q7JMN1

Conserved Domains (3) summary

cd01742
Location:61 → 243

GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase

PRK00074
Location:59 → 611

guaA; GMP synthase; Reviewed

cd01997
Location:274 → 744

GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...
NM_001083162.5 → NP_001076631.1 putative GMP synthase [glutamine-hydrolyzing] [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076631.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09580

Conserved Domains (3) summary

cd01742
Location:25 → 207

GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase

PRK00074
Location:23 → 575

guaA; GMP synthase; Reviewed

cd01997
Location:238 → 708

GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...