UFE1 Ufe1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: UFE1
Official Full Name: Ufe1p
Primary source: SGD:S000005601
Locus tag: YOR075W
See related: AllianceGenome:SGD:S000005601; FungiDB:YOR075W; VEuPathDB:YOR075W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable SNAP receptor activity. Involved in endoplasmic reticulum membrane fusion and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in endoplasmic reticulum. Part of SNARE complex. Orthologous to human STX18 (syntaxin 18). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See UFE1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (468212..469252)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An ER-localized SNARE protein UFE1 is exported in specific COPII vesicles for autophagosome biogenesis.
Title: An ER-Localized SNARE Protein Is Exported in Specific COPII Vesicles for Autophagosome Biogenesis.
Data show that the yeast Ufe1 is prone to degradation by an ERAD-like mechanism but is protected against degradation through binding to Sly1, a known SNARE regulator of the Sec1-Munc18 (SM) protein family.
Title: SM-protein-controlled ER-associated degradation discriminates between different SNAREs.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ufe1p

NP_014718.1

t-SNARE protein required for retrograde vesicular traffic; involved in Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

468212..469252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183494.1 → NP_014718.1 TPA: Ufe1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014718.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2D8, P41834

UniProtKB/TrEMBL

G2WMV3, N1NYB8

Conserved Domains (3) summary

COG5325
Location:170 → 341

COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]

cd15850
Location:258 → 316

SNARE_syntaxin18; SNARE motif, subgroup Qa

pfam10496
Location:4 → 90

Syntaxin-18_N; SNARE-complex protein Syntaxin-18 N-terminus