ZNF653 zinc finger protein 653 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF653provided by HGNC
Official Full Name: zinc finger protein 653provided by HGNC
Primary source: HGNC:HGNC:25196
See related: Ensembl:ENSG00000161914 MIM:611371; AllianceGenome:HGNC:25196
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZIP67; E430039K05Rik
Summary: Enables AF-2 domain binding activity; DNA-binding transcription factor binding activity; and transcription corepressor activity. Involved in extracellular negative regulation of signal transduction and negative regulation of transcription by RNA polymerase II. Predicted to be located in extracellular region. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis (RPKM 5.2), brain (RPKM 2.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (11483429..11505839, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (11610937..11633342, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (11594244..11616654, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

novel zinc-finger protein that influences gene activation through interaction with the functionally important activation function-2 domain of nuclear receptors
Title: Cloning and characterization of a novel zinc finger protein that modulates the transcriptional activity of nuclear receptors.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_7831-7832:996688076:1 (e-PCR)
- UniSTS:269828

D19S665E (e-PCR)
- UniSTS:150574

RH98319 (e-PCR)
- UniSTS:87283

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables AF-2 domain binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular negative regulation of signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: zinc finger protein 653

Names: 67 kDa zinc finger protein; zinc finger protein Zip67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138783.4 → NP_620138.2 zinc finger protein 653

See identical proteins and their annotated locations for NP_620138.2

Status: VALIDATED

Source sequence(s)

AK131037, BC014187, CB241280

Consensus CDS

CCDS12261.1

UniProtKB/Swiss-Prot

Q96AS7, Q96CK0

Related

ENSP00000293771.3, ENST00000293771.10

Conserved Domains (3) summary

COG5048
Location:486 → 614

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:503 → 522

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:514 → 539

zf-H2C2_2; Zinc-finger double domain