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    ARHGEF10L Rho guanine nucleotide exchange factor 10 like [ Homo sapiens (human) ]

    Gene ID: 55160, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ARHGEF10Lprovided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 10 likeprovided by HGNC
    Primary source
    HGNC:HGNC:25540
    See related
    Ensembl:ENSG00000074964 MIM:612494; AllianceGenome:HGNC:25540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GrinchGEF
    Summary
    This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]
    Expression
    Ubiquitous expression in kidney (RPKM 7.7), colon (RPKM 6.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARHGEF10L in Genome Data Viewer
    Location:
    1p36.13
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (17513435..17697875)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (17327447..17513168)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (17866193..18024370)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903862 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17786613-17787420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17794449-17795104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17795105-17795758 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17795759-17796412 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17796413-17797066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17814091-17814734 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:17820926-17821068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17840929-17841430 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:17847786-17848452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17848453-17849117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17873548-17874192 Neighboring gene Sharpr-MPRA regulatory region 1053 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17891467-17892088 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17892089-17892708 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17894951-17895467 Neighboring gene Sharpr-MPRA regulatory region 13018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17895984-17896500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17897017-17897533 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17907892-17908738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17915267-17915832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17916399-17916964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17934381-17934909 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17936808-17937309 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:17942885-17943386 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17955985-17956638 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:17956639-17957290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17974609-17975110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17992239-17992738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:17993258-17994044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18003408-18004017 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18009174-18009734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18010521-18011122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18012606-18013106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18013107-18013607 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18016134-18016866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18027273-18027872 Neighboring gene long intergenic non-protein coding RNA 2810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18094554-18095120 Neighboring gene actin like 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18152523-18153112

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ARHGEF10L expression regulates cell proliferation and migration in gastric tumorigenesis. Wang DW, et al. Biosci Biotechnol Biochem, 2020 Jul. PMID 32154766
    2. ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition. Tang J, et al. Exp Cell Res, 2019 Jan 1. PMID 30444969
    3. GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor. Winkler S, et al. Biochem Biophys Res Commun, 2005 Oct 7. PMID 16112081
    4. Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. Earp M, et al. PLoS One, 2018. PMID 29979793, Free PMC Article
    5. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. Stacey SN, et al. Nat Genet, 2008 Nov. PMID 18849993

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARHGEF10L expression regulates cell proliferation and migration in gastric tumorigenesis.
      Title: ARHGEF10L expression regulates cell proliferation and migration in gastric tumorigenesis.
    2. increased expression of ARHGEF10L stimulates hepatocellular tumorigenesis by activating the RhoA-ROCK1- phospho Ezrin/Radixin/Moesin pathway and epithelial-mesenchymal transition.
      Title: ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition.
    3. Inherited variants in ARHGEF10L and AKAP6, with potential transcriptional regulatory function and association with Epithelial ovarian cancer risk, warrant investigation in independent Epithelial ovarian cancer study populations.
      Title: Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Mutation of ARHGAP9 in patients with coronary spastic angina.
    6. In intact cells, GrinchGEF induced specifically Rho activation and enhanced RhoA-C-specific downstream effects.
      Title: GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor.
    7. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog
    Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10521, KIAA1626

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SREBP signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 10-like protein
    Names
    Rho guanine nucleotide exchange factor (GEF) 10-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050860.2 RefSeqGene

      Range
      31265..189436
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001011722.2 → NP_001011722.2  rho guanine nucleotide exchange factor 10-like protein isoform 2

      See identical proteins and their annotated locations for NP_001011722.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon, as compared to variant 1. The encoded isoform 2 thus lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AB046846, AK092020, AW455769, BC080596
      Consensus CDS
      CCDS30617.1
      UniProtKB/TrEMBL
      A0A2X0U2F8
      Related
      ENSP00000364564.1, ENST00000375415.5
      Conserved Domains (3) summary
      pfam00621
      Location:285 → 463
      RhoGEF; RhoGEF domain
      sd00039
      Location:888 → 931
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:861 → 1011
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001319837.1 → NP_001306766.1  rho guanine nucleotide exchange factor 10-like protein isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform 3, which lacks two separate internal in-frame segments and is shorter than isoform 1.
      Source sequence(s)
      AB046846, BC111058, BU738615, DQ139833
      UniProtKB/TrEMBL
      A0A2X0U2F8
      Conserved Domains (3) summary
      pfam00621
      Location:285 → 463
      RhoGEF; RhoGEF domain
      sd00039
      Location:883 → 926
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:856 → 1006
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001319838.1 → NP_001306767.1  rho guanine nucleotide exchange factor 10-like protein isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter. It differs in the 5' UTR and 5' coding region, uses an alternate start codon and lacks three alternate exons in the coding region, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK092020, BC111058, BU738615, DA468685, DQ139833
      UniProtKB/TrEMBL
      B3KX74
      Conserved Domains (3) summary
      sd00039
      Location:630 → 673
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:603 → 753
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl02571
      Location:102 → 210
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    4. NM_001328124.1 → NP_001315053.1  rho guanine nucleotide exchange factor 10-like protein isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents use of an alternate promoter and contains novel 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 5, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK092020, AK300264, BC080596, BC111058, DA468685
      UniProtKB/TrEMBL
      B3KX74
      Conserved Domains (3) summary
      pfam00621
      Location:102 → 280
      RhoGEF; RhoGEF domain
      sd00039
      Location:705 → 748
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:678 → 828
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. NM_018125.4 → NP_060595.3  rho guanine nucleotide exchange factor 10-like protein isoform 1

      See identical proteins and their annotated locations for NP_060595.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB046846, AK092020, AL390994, AW455769, BC065561
      Consensus CDS
      CCDS182.1
      UniProtKB/Swiss-Prot
      B7ZKS1, Q17RW1, Q3YFJ4, Q5VXI5, Q5VXI6, Q66K51, Q6P0L7, Q8NAV5, Q9HCE6, Q9NVT3
      UniProtKB/TrEMBL
      A0A2X0U2F8
      Related
      ENSP00000355060.3, ENST00000361221.8
      Conserved Domains (2) summary
      cd00160
      Location:317 → 501
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      sd00039
      Location:927 → 970
      7WD40; WD40 repeat [structural motif]

    RNA

    1. NR_137287.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB046846, AK092020, AL358593, AL390994, BC111058

    2. NR_137288.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks an alternate internal exon and contains an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB046846, AK092020, AL358593, AL390994, BC111058

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      17513435..17697875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448061.2 → XP_024303829.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      UniProtKB/TrEMBL
      A0A2X0U2F8
      Conserved Domains (2) summary
      cd00160
      Location:282 → 466
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      sd00039
      Location:892 → 935
      7WD40; WD40 repeat [structural motif]

    2. XM_006710728.1 → XP_006710791.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      See identical proteins and their annotated locations for XP_006710791.1

      UniProtKB/TrEMBL
      A0A2X0U2F8
      Conserved Domains (2) summary
      cd00160
      Location:282 → 466
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      sd00039
      Location:892 → 935
      7WD40; WD40 repeat [structural motif]

    3. XM_047424089.1 → XP_047280045.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

    4. XM_006710731.1 → XP_006710794.1  rho guanine nucleotide exchange factor 10-like protein isoform X2

      See identical proteins and their annotated locations for XP_006710794.1

      UniProtKB/TrEMBL
      A0A2X0U2F8
      Conserved Domains (3) summary
      pfam00621
      Location:288 → 466
      RhoGEF; RhoGEF domain
      sd00039
      Location:891 → 934
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:864 → 1014
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_047424111.1 → XP_047280067.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

    6. XM_047424100.1 → XP_047280056.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

    7. XM_047424075.1 → XP_047280031.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    8. XM_005245923.3 → XP_005245980.2  rho guanine nucleotide exchange factor 10-like protein isoform X1

      See identical proteins and their annotated locations for XP_005245980.2

      UniProtKB/TrEMBL
      A0A2X0U2F8
      Conserved Domains (2) summary
      cd00160
      Location:282 → 466
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      sd00039
      Location:892 → 935
      7WD40; WD40 repeat [structural motif]

    9. XM_047424093.1 → XP_047280049.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

    10. XM_006710729.2 → XP_006710792.1  rho guanine nucleotide exchange factor 10-like protein isoform X2

      See identical proteins and their annotated locations for XP_006710792.1

      UniProtKB/TrEMBL
      A0A2X0U2F8
      Conserved Domains (3) summary
      pfam00621
      Location:288 → 466
      RhoGEF; RhoGEF domain
      sd00039
      Location:891 → 934
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:864 → 1014
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    11. XM_005245925.3 → XP_005245982.2  rho guanine nucleotide exchange factor 10-like protein isoform X4

      See identical proteins and their annotated locations for XP_005245982.2

      UniProtKB/TrEMBL
      A0A2X0U2F8
      Conserved Domains (3) summary
      pfam00621
      Location:285 → 463
      RhoGEF; RhoGEF domain
      sd00039
      Location:888 → 931
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:861 → 1011
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    12. XM_017001617.2 → XP_016857106.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

      UniProtKB/TrEMBL
      A0A2X0U2F8
      Conserved Domains (3) summary
      pfam00621
      Location:285 → 463
      RhoGEF; RhoGEF domain
      sd00039
      Location:883 → 926
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:856 → 1006
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    13. XM_047424065.1 → XP_047280021.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    14. XM_047424097.1 → XP_047280053.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

    15. XM_047424112.1 → XP_047280068.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

    16. XM_047424071.1 → XP_047280027.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    17. XM_047424070.1 → XP_047280026.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    18. XM_024448059.2 → XP_024303827.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      UniProtKB/TrEMBL
      A0A2X0U2F8
      Conserved Domains (2) summary
      cd00160
      Location:282 → 466
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      sd00039
      Location:892 → 935
      7WD40; WD40 repeat [structural motif]

    19. XM_047424098.1 → XP_047280054.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

    20. XM_024448062.1 → XP_024303830.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      UniProtKB/TrEMBL
      A0A2X0U2F8
      Conserved Domains (2) summary
      cd00160
      Location:282 → 466
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      sd00039
      Location:892 → 935
      7WD40; WD40 repeat [structural motif]

    21. XM_047424096.1 → XP_047280052.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

    22. XM_047424105.1 → XP_047280061.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

    23. XM_011541692.3 → XP_011539994.1  rho guanine nucleotide exchange factor 10-like protein isoform X5

      UniProtKB/TrEMBL
      A0A2X0U2F8
      Conserved Domains (3) summary
      pfam00621
      Location:289 → 467
      RhoGEF; RhoGEF domain
      sd00039
      Location:887 → 930
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:860 → 1010
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    24. XM_011541691.3 → XP_011539993.1  rho guanine nucleotide exchange factor 10-like protein isoform X3

      UniProtKB/TrEMBL
      A0A2X0U2F8
      Conserved Domains (3) summary
      pfam00621
      Location:286 → 464
      RhoGEF; RhoGEF domain
      sd00039
      Location:889 → 932
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:862 → 1012
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    25. XM_017001619.2 → XP_016857108.1  rho guanine nucleotide exchange factor 10-like protein isoform X9

    26. XM_017001620.2 → XP_016857109.1  rho guanine nucleotide exchange factor 10-like protein isoform X10

    27. XM_047424158.1 → XP_047280114.1  rho guanine nucleotide exchange factor 10-like protein isoform X11

    28. XM_047424175.1 → XP_047280131.1  rho guanine nucleotide exchange factor 10-like protein isoform X15

    29. XM_047424159.1 → XP_047280115.1  rho guanine nucleotide exchange factor 10-like protein isoform X12

    30. XM_047424190.1 → XP_047280146.1  rho guanine nucleotide exchange factor 10-like protein isoform X16

    31. XM_047424165.1 → XP_047280121.1  rho guanine nucleotide exchange factor 10-like protein isoform X13

    32. XM_047424167.1 → XP_047280123.1  rho guanine nucleotide exchange factor 10-like protein isoform X14

    33. XM_047424201.1 → XP_047280157.1  rho guanine nucleotide exchange factor 10-like protein isoform X17

    34. XM_005245929.4 → XP_005245986.2  rho guanine nucleotide exchange factor 10-like protein isoform X8

      UniProtKB/TrEMBL
      B3KX74, Q5VXI4
      Related
      ENSP00000364557.3, ENST00000375408.7
      Conserved Domains (3) summary
      pfam00621
      Location:102 → 280
      RhoGEF; RhoGEF domain
      sd00039
      Location:700 → 743
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:673 → 823
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_946686.4 RNA Sequence

    2. XR_946691.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      17327447..17513168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337380.1 → XP_054193355.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    2. XM_054337377.1 → XP_054193352.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    3. XM_054337389.1 → XP_054193364.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

    4. XM_054337384.1 → XP_054193359.1  rho guanine nucleotide exchange factor 10-like protein isoform X2

    5. XM_054337396.1 → XP_054193371.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

    6. XM_054337394.1 → XP_054193369.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

    7. XM_054337383.1 → XP_054193358.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    8. XM_054337376.1 → XP_054193351.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    9. XM_054337390.1 → XP_054193365.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

    10. XM_054337385.1 → XP_054193360.1  rho guanine nucleotide exchange factor 10-like protein isoform X2

    11. XM_054337387.1 → XP_054193362.1  rho guanine nucleotide exchange factor 10-like protein isoform X4

    12. XM_054337398.1 → XP_054193373.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

    13. XM_054337375.1 → XP_054193350.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    14. XM_054337392.1 → XP_054193367.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

    15. XM_054337397.1 → XP_054193372.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

    16. XM_054337382.1 → XP_054193357.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    17. XM_054337393.1 → XP_054193368.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

    18. XM_054337381.1 → XP_054193356.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    19. XM_054337378.1 → XP_054193353.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    20. XM_054337379.1 → XP_054193354.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

    21. XM_054337391.1 → XP_054193366.1  rho guanine nucleotide exchange factor 10-like protein isoform X6

    22. XM_054337395.1 → XP_054193370.1  rho guanine nucleotide exchange factor 10-like protein isoform X7

    23. XM_054337388.1 → XP_054193363.1  rho guanine nucleotide exchange factor 10-like protein isoform X5

    24. XM_054337386.1 → XP_054193361.1  rho guanine nucleotide exchange factor 10-like protein isoform X3

    25. XM_054337400.1 → XP_054193375.1  rho guanine nucleotide exchange factor 10-like protein isoform X9

    26. XM_054337401.1 → XP_054193376.1  rho guanine nucleotide exchange factor 10-like protein isoform X10

    27. XM_054337402.1 → XP_054193377.1  rho guanine nucleotide exchange factor 10-like protein isoform X11

    28. XM_054337406.1 → XP_054193381.1  rho guanine nucleotide exchange factor 10-like protein isoform X15

    29. XM_054337403.1 → XP_054193378.1  rho guanine nucleotide exchange factor 10-like protein isoform X12

    30. XM_054337407.1 → XP_054193382.1  rho guanine nucleotide exchange factor 10-like protein isoform X16

    31. XM_054337404.1 → XP_054193379.1  rho guanine nucleotide exchange factor 10-like protein isoform X13

    32. XM_054337405.1 → XP_054193380.1  rho guanine nucleotide exchange factor 10-like protein isoform X14

    33. XM_054337408.1 → XP_054193383.1  rho guanine nucleotide exchange factor 10-like protein isoform X17

    34. XM_054337399.1 → XP_054193374.1  rho guanine nucleotide exchange factor 10-like protein isoform X8

    RNA

    1. XR_008486087.1 RNA Sequence

    2. XR_008486088.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HCE6.4 GenPept UniProtKB/Swiss-Prot:Q9HCE6

    Gene LinkOut

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