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    NREP neuronal regeneration related protein [ Homo sapiens (human) ]

    Gene ID: 9315, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NREPprovided by HGNC
    Official Full Name
    neuronal regeneration related proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16834
    See related
    Ensembl:ENSG00000134986 MIM:607332; AllianceGenome:HGNC:16834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P311; PTZ17; SEZ17; D4S114; C5orf13; PRO1873
    Summary
    Predicted to be involved in axon regeneration; regulation of neuron differentiation; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 38.4), placenta (RPKM 35.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NREP in Genome Data Viewer
    Location:
    5q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (111728802..111976932, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (112239135..112487266, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (111064499..111312629, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene STARD4 antisense RNA 1 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:111092091-111092648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16234 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16235 Neighboring gene RN7SK pseudogene 57 Neighboring gene uncharacterized LOC105379122 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 14 Neighboring gene NREP antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111326855-111327356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111327357-111327856 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:111333199-111334398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22904 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:111496090-111497289 Neighboring gene EPB41L4A antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:111501161-111501838 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:111501839-111502516 Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene uncharacterized LOC124901044 Neighboring gene small nucleolar RNA, H/ACA box 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes. De Jesus DF, et al. Cell Chem Biol, 2023 Sep 21. PMID 37354909, Free PMC Article
    2. Regulation of P311 expression by Met-hepatocyte growth factor/scatter factor and the ubiquitin/proteasome system. Taylor GA, et al. J Biol Chem, 2000 Feb 11. PMID 10660586
    3. Regulation of glioma cell migration by serine-phosphorylated P311. McDonough WS, et al. Neoplasia, 2005 Sep. PMID 16229809, Free PMC Article
    4. Investigating the role of P311 in the hypertrophic scar. Tan J, et al. PLoS One, 2010 Apr 9. PMID 20404911, Free PMC Article
    5. An abundant mRNA of the embryonic brain persists at a high level in cerebellum, hippocampus and olfactory bulb during adulthood. Studler JM, et al. Eur J Neurosci, 1993 Jun 1. PMID 8261136

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. H3K18 lactylation promotes the progression of arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP.
      Title: H3K18 lactylation promotes the progression of arsenite-related idiopathic pulmonary fibrosis via YTHDF1/m6A/NREP.
    2. NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes.
      Title: NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes.
    3. P311 Promotes IL-4 Receptor-Mediated M2 Polarization of Macrophages to Enhance Angiogenesis for Efficient Skin Wound Healing.
      Title: P311 Promotes IL-4 Receptor‒Mediated M2 Polarization of Macrophages to Enhance Angiogenesis for Efficient Skin Wound Healing.
    4. P311 expression in the in the lungs of patients with idiopathic pulmonary fibrosis.
      Title: P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-β1, -β2, and -β3 Translation.
    5. P311 is a novel TGFbeta1/Smad signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
      Title: P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression.
    6. P311 could accelerate skin wound reepithelialization by promoting the migration of Epidermal Stem Cell through RhoA and Rac1 activation.
      Title: P311 Accelerates Skin Wound Reepithelialization by Promoting Epidermal Stem Cell Migration Through RhoA and Rac1 Activation.
    7. These studies demonstrate that P311 is required for the production of normal cutaneous scars
      Title: Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar Collagen Deposition and Tensile Strength due to Impaired Transforming Growth Factor-β1 to -β3 Translation.
    8. P311 plays a key role in renal fibrosis via TGFbeta1/Smad signaling, which could be a novel target for the management of renal fibrosis.
      Title: P311 promotes renal fibrosis via TGFβ1/Smad signaling.
    9. Novel RNA-binding protein P311 binds eIF3b to promote translation of TGF-beta1, TGF-beta2, TGF-beta3.
      Title: Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor β1-3 (TGF-β1-3).
    10. P311 may promote the migration of ESCs both in micewith superficial partial-thickness burns and in an injured cell model in vitro, and it may play an important role in wound healing.
      Title: [Effects of P 311 on the migration of epidermal stem cells in mice with superficial partial-thickness burn and injured cell model in vitro].
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of neuronal regeneration related protein homolog (rat, NREP; P311; C5orf13) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon regeneration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuronal regeneration-related protein
    Names
    neuronal protein 3.1
    neuronal regeneration related protein homolog
    protein p311

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142474.2 → NP_001135946.1  neuronal regeneration-related protein isoform b

      See identical proteins and their annotated locations for NP_001135946.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes alternate exons in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform b, which is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC022108, AC025182, DA027062, DA694580
      Conserved Domains (1) summary
      pfam11092
      Location:37 → 102
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    2. NM_001142475.2 → NP_001135947.1  neuronal regeneration-related protein isoform c

      See identical proteins and their annotated locations for NP_001135947.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) includes alternate exons in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform c, which is longer and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC022108, AC025182, DC365764
      Consensus CDS
      CCDS47255.1
      UniProtKB/Swiss-Prot
      Q16612
      Related
      ENSP00000378996.3, ENST00000395634.7
      Conserved Domains (1) summary
      pfam11092
      Location:47 → 112
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    3. NM_001142476.1 → NP_001135948.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135948.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA490948, DA526263
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000392559.2, ENST00000455559.6
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    4. NM_001142477.1 → NP_001135949.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135949.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA939543
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000427476.1, ENST00000513100.5
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    5. NM_001142478.2 → NP_001135950.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135950.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, AC114297, AL547663, BC011050
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000368993.3, ENST00000379671.7
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    6. NM_001142479.1 → NP_001135951.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135951.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA520221, DA704824
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000399766.2, ENST00000419114.6
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    7. NM_001142480.1 → NP_001135952.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135952.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA704824, DA744980
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    8. NM_001142481.1 → NP_001135953.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA752769
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000422630.1, ENST00000509427.5
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    9. NM_001142482.1 → NP_001135954.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135954.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA683910
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000402965.2, ENST00000446294.6
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    10. NM_001142483.1 → NP_001135955.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_001135955.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      AC022108, DA078027, DA534424
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000408839.2, ENST00000447165.6
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    11. NM_004772.4 → NP_004763.1  neuronal regeneration-related protein isoform a

      See identical proteins and their annotated locations for NP_004763.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shortest isoform (a). Variants 1, 4, 5, 6, 7, 8, 9, 10, and 11 encode the same isoform.
      Source sequence(s)
      BC072443, CN415439
      Consensus CDS
      CCDS4105.1
      UniProtKB/Swiss-Prot
      B2RDN8, B7Z5D2, D3DSZ8, Q16612
      UniProtKB/TrEMBL
      D6RIC9
      Related
      ENSP00000257435.7, ENST00000257435.12
      Conserved Domains (1) summary
      pfam11092
      Location:3 → 68
      Alveol-reg_P311; Neuronal protein 3.1 (p311)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      111728802..111976932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      112239135..112487266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353798.1 → XP_054209773.1  neuronal regeneration-related protein isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16612.1 GenPept UniProtKB/Swiss-Prot:Q16612

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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