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    Ddx24 DEAD-box helicase 24 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 373065, updated on 2-Nov-2024

    Summary

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    Symbol
    Ddx24provided by RGD
    Full Name
    DEAD-box helicase 24provided by RGD
    Primary source
    RGD:727929
    See related
    EnsemblRapid:ENSRNOG00000009166 AllianceGenome:RGD:727929
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Predicted to be active in nucleolus. Orthologous to human DDX24 (DEAD-box helicase 24). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 223.6), Brain (RPKM 203.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ddx24 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (128329554..128346818, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (122564767..122582032, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (127302201..127319382, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549032 Neighboring gene OTU deubiquitinase, ubiquitin aldehyde binding 2 Neighboring gene interferon, alpha-inducible protein 27 Neighboring gene interferon, alpha-inducible protein 27 like 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DExD/H-box RNA helicases in ribosome biogenesis. Martin R, et al. RNA Biol, 2013 Jan. PMID 22922795, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase DDX24
    Names
    ATP-dependent RNA helicase DDX24-like
    DEAD (Asp-Glu-Ala-Asp) box helicase 24
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
    NP_954550.1
    XP_006240545.1
    XP_006240546.1
    XP_063118313.1
    XP_063118314.1
    XP_063118315.1
    XP_063118316.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199119.1 → NP_954550.1  ATP-dependent RNA helicase DDX24

      See identical proteins and their annotated locations for NP_954550.1

      Status: PROVISIONAL

      Source sequence(s)
      AY341876
      UniProtKB/TrEMBL
      A0A8I6AFW4, A6JEM9, F7ETB4, Q6VEU8
      Related
      ENSRNOP00000012256.2, ENSRNOT00000012256.5
      Conserved Domains (3) summary
      COG0513
      Location:191 → 735
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00271
      Location:567 → 675
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:194 → 505
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      128329554..128346818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240483.3 → XP_006240545.1  ATP-dependent RNA helicase DDX24 isoform X1

      See identical proteins and their annotated locations for XP_006240545.1

      UniProtKB/TrEMBL
      A0A8I6AFW4, A6JEM9, F7ETB4, Q6VEU8
      Conserved Domains (3) summary
      COG0513
      Location:191 → 735
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00271
      Location:567 → 675
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:194 → 505
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_063262243.1 → XP_063118313.1  ATP-dependent RNA helicase DDX24 isoform X1

      UniProtKB/TrEMBL
      A6JEM9, F7ETB4, Q6VEU8

    3. XM_063262244.1 → XP_063118314.1  ATP-dependent RNA helicase DDX24 isoform X1

      UniProtKB/TrEMBL
      A6JEM9, F7ETB4, Q6VEU8

    4. XM_063262245.1 → XP_063118315.1  ATP-dependent RNA helicase DDX24 isoform X1

      UniProtKB/TrEMBL
      A6JEM9, F7ETB4, Q6VEU8

    5. XM_006240484.4 → XP_006240546.1  ATP-dependent RNA helicase DDX24 isoform X1

      See identical proteins and their annotated locations for XP_006240546.1

      UniProtKB/TrEMBL
      A0A8I6AFW4, A6JEM9, F7ETB4, Q6VEU8
      Conserved Domains (3) summary
      COG0513
      Location:191 → 735
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      pfam00271
      Location:567 → 675
      Helicase_C; Helicase conserved C-terminal domain
      cl21455
      Location:194 → 505
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. XM_063262246.1 → XP_063118316.1  ATP-dependent RNA helicase DDX24 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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