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    Pakap paralemmin A kinase anchor protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298024, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pakapprovided by RGD
    Official Full Name
    paralemmin A kinase anchor proteinprovided by RGD
    Primary source
    RGD:1305135
    See related
    EnsemblRapid:ENSRNOG00000011504 AllianceGenome:RGD:1305135
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Akap2; Palm2; AKAP-2
    Summary
    Enables protein domain specific binding activity. Predicted to be involved in regulation of cell shape. Predicted to act upstream of or within actin filament organization; cell surface receptor protein serine/threonine kinase signaling pathway; and protein localization. Part of protein-containing complex. Orthologous to human PALM2AKAP2 (PALM2 and AKAP2 fusion). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 657.0), Kidney (RPKM 591.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pakap in Genome Data Viewer
    Location:
    5q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (76976906..77443656)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (72536986..72648524)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (74874245..74985789)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100910620 Neighboring gene uncharacterized LOC120102883 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 8 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134486938 Neighboring gene similar to human chromosome 9 open reading frame 152 Neighboring gene thioredoxin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Kinderman FS, et al. Mol Cell, 2006 Nov 3. PMID 17081990, Free PMC Article
    2. Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein. Dong F, et al. J Biol Chem, 1998 Mar 13. PMID 9497389
    3. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, et al. IUBMB Life, 2009 Apr. PMID 19319965, Free PMC Article
    4. Localized effects of cAMP mediated by distinct routes of protein kinase A. Taskén K, et al. Physiol Rev, 2004 Jan. PMID 14715913
    5. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein 2
    Names
    A kinase (PRKA) anchor protein 2
    A-kinase anchoring protein 2
    paralemmin 2
    paralemmin-2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011974.2 → NP_001011974.2  A-kinase anchor protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q5U301
      Conserved Domains (2) summary
      PHA03247
      Location:613 → 810
      PHA03247; large tegument protein UL36; Provisional
      pfam15304
      Location:721 → 862
      AKAP2_C; A-kinase anchor protein 2 C-terminus

    2. NM_001305995.1 → NP_001292924.1  A-kinase anchor protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D4A4D8

    3. NM_001309260.1 → NP_001296189.1  A-kinase anchor protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001296189.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q5U301
      UniProtKB/TrEMBL
      A0A8I6A5A3
      Conserved Domains (1) summary
      pfam15304
      Location:721 → 875
      AKAP2_C; A-kinase anchor protein 2 C-terminus

    4. NM_001425400.1 → NP_001412329.1  A-kinase anchor protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      Related
      ENSRNOP00000089455.2, ENSRNOT00000098662.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      76976906..77443656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287310.1 → XP_063143380.1  A-kinase anchor protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y1X4
      Related
      ENSRNOP00000077701.2, ENSRNOT00000106097.2

    2. XM_063287308.1 → XP_063143378.1  A-kinase anchor protein 2 isoform X1

    3. XM_063287309.1 → XP_063143379.1  A-kinase anchor protein 2 isoform X2

      Related
      ENSRNOP00000087137.2, ENSRNOT00000097436.2

    4. XM_063287311.1 → XP_063143381.1  A-kinase anchor protein 2 isoform X4

      Related
      ENSRNOP00000092250.2, ENSRNOT00000117085.2

    5. XM_063287312.1 → XP_063143382.1  A-kinase anchor protein 2 isoform X5

    6. XM_063287313.1 → XP_063143383.1  A-kinase anchor protein 2 isoform X6

    7. XM_063287314.1 → XP_063143384.1  A-kinase anchor protein 2 isoform X7

    8. XM_006238186.4 → XP_006238248.1  A-kinase anchor protein 2 isoform X11

      See identical proteins and their annotated locations for XP_006238248.1

      UniProtKB/Swiss-Prot
      Q5U301
      UniProtKB/TrEMBL
      A0A8I6A5A3
      Conserved Domains (1) summary
      pfam15304
      Location:721 → 875
      AKAP2_C; A-kinase anchor protein 2 C-terminus

    9. XM_063287318.1 → XP_063143388.1  A-kinase anchor protein 2 isoform X12

    10. XM_063287321.1 → XP_063143391.1  A-kinase anchor protein 2 isoform X15

    11. XM_063287315.1 → XP_063143385.1  A-kinase anchor protein 2 isoform X8

    12. XM_063287317.1 → XP_063143387.1  A-kinase anchor protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A8I6ADB4

    13. XM_063287320.1 → XP_063143390.1  A-kinase anchor protein 2 isoform X14

    14. XM_063287316.1 → XP_063143386.1  A-kinase anchor protein 2 isoform X9

      Related
      ENSRNOP00000090369.2, ENSRNOT00000114485.2

    15. XM_063287319.1 → XP_063143389.1  A-kinase anchor protein 2 isoform X13

    16. XM_006238185.5 → XP_006238247.1  A-kinase anchor protein 2 isoform X11

      See identical proteins and their annotated locations for XP_006238247.1

      UniProtKB/Swiss-Prot
      Q5U301
      UniProtKB/TrEMBL
      A0A8I6A5A3
      Conserved Domains (1) summary
      pfam15304
      Location:721 → 875
      AKAP2_C; A-kinase anchor protein 2 C-terminus

    17. XM_039109444.2 → XP_038965372.1  A-kinase anchor protein 2 isoform X12

      UniProtKB/Swiss-Prot
      Q5U301
      Conserved Domains (2) summary
      PHA03247
      Location:613 → 810
      PHA03247; large tegument protein UL36; Provisional
      pfam15304
      Location:721 → 862
      AKAP2_C; A-kinase anchor protein 2 C-terminus

    18. XM_039109446.2 → XP_038965374.1  A-kinase anchor protein 2 isoform X15

      UniProtKB/TrEMBL
      F1LPQ9
      Conserved Domains (1) summary
      COG3611
      Location:201 → 272
      DnaB; Replication initiation and membrane attachment protein DnaB [Replication, recombination and repair]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U301.1 GenPept UniProtKB/Swiss-Prot:Q5U301

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