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    Gng2 G protein subunit gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 80850, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gng2provided by RGD
    Official Full Name
    G protein subunit gamma 2provided by RGD
    Primary source
    RGD:69268
    See related
    EnsemblRapid:ENSRNOG00000048980 AllianceGenome:RGD:69268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and fibroblast proliferation. Part of heterotrimeric G-protein complex. Orthologous to human GNG2 (G protein subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 274.5), Spleen (RPKM 92.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gng2 in Genome Data Viewer
    Location:
    15p16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (4365222..4466060)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (4316038..4416918)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (4748242..4853555)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene SAYSVFN motif domain containing 1 Neighboring gene uncharacterized LOC134481915 Neighboring gene uncharacterized LOC102554918 Neighboring gene RNA transcription, translation and transport factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis illuminates a novel structural definition of the claustrum and insula. Mathur BN, et al. Cereb Cortex, 2009 Oct. PMID 19168664, Free PMC Article
    2. Gβγ and the C terminus of SNAP-25 are necessary for long-term depression of transmitter release. Zhang XL, et al. PLoS One, 2011. PMID 21633701, Free PMC Article
    3. Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. Khurana S, et al. Exp Cell Res, 2008 Feb 1. PMID 18054784, Free PMC Article
    4. Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain. Betty M, et al. Neuroscience, 1998 Jul. PMID 9622245
    5. Direct interactions between the heterotrimeric G protein subunit G beta 5 and the G protein gamma subunit-like domain-containing regulator of G protein signaling 11: gain of function of cyan fluorescent protein-tagged G gamma 3. Zhou JY, et al. J Pharmacol Exp Ther, 2003 May. PMID 12606627

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Names
    guanine nucleotide binding protein (G protein), gamma 2 subunit
    NP_001244278.1
    NP_113942.1
    XP_038949608.1
    XP_038949609.1
    XP_038949610.1
    XP_063130760.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257349.1 → NP_001244278.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      See identical proteins and their annotated locations for NP_001244278.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KKL4
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    2. NM_031754.1 → NP_113942.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

      See identical proteins and their annotated locations for NP_113942.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KKL4
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      4365222..4466060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093680.2 → XP_038949608.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

      UniProtKB/TrEMBL
      A6KKL4
      Related
      ENSRNOP00000106054.1, ENSRNOT00000071133.4
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    2. XM_039093681.2 → XP_038949609.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

      UniProtKB/TrEMBL
      A6KKL4
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    3. XM_039093682.2 → XP_038949610.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

      UniProtKB/TrEMBL
      A6KKL4
      Conserved Domains (1) summary
      smart00224
      Location:9 → 71
      GGL; G protein gamma subunit-like motifs

    4. XM_063274690.1 → XP_063130760.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1

      UniProtKB/TrEMBL
      A6KKL4
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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