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    TMPRSS11B transmembrane serine protease 11B [ Homo sapiens (human) ]

    Gene ID: 132724, updated on 14-Nov-2024

    Summary

    Official Symbol
    TMPRSS11Bprovided by HGNC
    Official Full Name
    transmembrane serine protease 11Bprovided by HGNC
    Primary source
    HGNC:HGNC:25398
    See related
    Ensembl:ENSG00000185873 AllianceGenome:HGNC:25398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HATL5
    Summary
    Enables serine-type peptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward esophagus (RPKM 184.2) See more
    Orthologs
    NEW
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    Genomic context

    See TMPRSS11B in Genome Data Viewer
    Location:
    4q13.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (68226653..68245694, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (71666935..71685995, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (69092371..69111412, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transmembrane serine protease 11F Neighboring gene solute carrier family 47 member 2 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr4:68979095-68979596 Neighboring gene TMPRSS11B N-terminal like (pseudogene) Neighboring gene ferritin light chain pseudogene 10 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:69137738-69138313 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:69138314-69138888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:69143050-69143592 Neighboring gene UDP glucuronosyltransferase family 2 member B11 pseudogene Neighboring gene apolipoprotein O pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    General gene information

    Clone Names

    • DKFZp686L1818

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in proteolysis  
    Component Evidence Code Pubs
    located_in extracellular exosome PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    transmembrane protease serine 11B
    Names
    airway trypsin-like protease 5
    transmembrane protease, serine 11B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182502.3NP_872308.2  transmembrane protease serine 11B

      See identical proteins and their annotated locations for NP_872308.2

      Status: VALIDATED

      Source sequence(s)
      AC098799, AK290904
      Consensus CDS
      CCDS3521.1
      UniProtKB/Swiss-Prot
      A8K4D9, Q86T26
      Related
      ENSP00000330475.5, ENST00000332644.6
      Conserved Domains (3) summary
      smart00020
      Location:184410
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:185413
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:45143
      SEA; SEA domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      68226653..68245694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531608.3XP_011529910.1  transmembrane protease serine 11B isoform X1

      See identical proteins and their annotated locations for XP_011529910.1

      UniProtKB/Swiss-Prot
      A8K4D9, Q86T26
      Conserved Domains (3) summary
      smart00020
      Location:184410
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:185413
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam01390
      Location:45143
      SEA; SEA domain
    2. XM_011531609.1XP_011529911.1  transmembrane protease serine 11B isoform X2

      Conserved Domains (2) summary
      pfam01390
      Location:45143
      SEA; SEA domain
      cl21584
      Location:185227
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      71666935..71685995 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348922.1XP_054204897.1  transmembrane protease serine 11B isoform X1

    2. XM_054348923.1XP_054204898.1  transmembrane protease serine 11B isoform X2

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