OAS1 2'-5'-oligoadenylate synthetase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OAS1provided by HGNC
Official Full Name: 2'-5'-oligoadenylate synthetase 1provided by HGNC
Primary source: HGNC:HGNC:8086
See related: Ensembl:ENSG00000089127 MIM:164350; AllianceGenome:HGNC:8086
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OIAS; IFI-4; OIASI; IMD100; E18/E16
Summary: This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection, including SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, May 2022]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Ubiquitous expression in spleen (RPKM 18.0), colon (RPKM 15.8) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 12q24.13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (112906962..112933219)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (112883649..112909905)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (113344767..113371024)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prognostic value and molecular mechanisms of OAS1 in lung adenocarcinoma.
Title: Prognostic value and molecular mechanisms of OAS1 in lung adenocarcinoma.
Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production.
Title: Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production.
Prevalence of the protective OAS1 rs10774671-G allele against severe COVID-19 in Moroccans: implications for a North African Neanderthal connection.
Title: Prevalence of the protective OAS1 rs10774671-G allele against severe COVID-19 in Moroccans: implications for a North African Neanderthal connection.
Possible effect of OAS1 and TMPRSS6 but not DPP4 and ZNF335 polymorphisms on COVID-19 severity in the Czech population.
Title: Possible effect of OAS1 and TMPRSS6 but not DPP4 and ZNF335 polymorphisms on COVID-19 severity in the Czech population.
Features of Distribution of the Allelic Variant of the OAS1 Gene Associated with Severe Form of the Coronavirus Infection in the Russian and Global Populations.
Title: Features of Distribution of the Allelic Variant of the OAS1 Gene Associated with Severe Form of the Coronavirus Infection in the Russian and Global Populations.
Elevation of H3K27me3 level contributes to the radioresistance of nasopharyngeal carcinoma by inhibiting OAS1 expression.
Title: Elevation of H3K27me3 level contributes to the radioresistance of nasopharyngeal carcinoma by inhibiting OAS1 expression.
The EMT-Related Genes GALNT3 and OAS1 are Associated with Immune Cell Infiltration and Poor Prognosis in Lung Adenocarcinoma.
Title: The EMT-Related Genes GALNT3 and OAS1 are Associated with Immune Cell Infiltration and Poor Prognosis in Lung Adenocarcinoma.
The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are Involved in the Regulation of CD44 mRNA Splicing in Colorectal Cancer Cells.
Title: The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are Involved in the Regulation of CD44 mRNA Splicing in Colorectal Cancer Cells.
Genetic Ethnic Differences in Human 2'-5'-Oligoadenylate Synthetase and Disease Associations: A Systematic Review.
Title: Genetic Ethnic Differences in Human 2'-5'-Oligoadenylate Synthetase and Disease Associations: A Systematic Review.
Genomic and RNA-Seq profiling of patients with HFrEF unraveled OAS1 mutation and aggressive expression.
Title: Genomic and RNA-Seq profiling of patients with HFrEF unraveled OAS1 mutation and aggressive expression.

Submit: New GeneRIF Correction See all GeneRIFs (94)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Pulmonary alveolar proteinosis with hypogammaglobulinemia MedGen: C4747984 OMIM: 618042 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates the expression of 2'-5'-oligoadenylate synthetase 1 (OAS1) in human B cells	PubMed
Nef	nef	Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Nef may antagonize restriction activity of OAS1 against production of infectious wild-type HIV-1	PubMed
Tat	tat	HIV-1 and the viral protein Tat modulate the expression of 2',5'-oligoadenylate synthetase 1, 40/46kDa (OAS1) in immature dendritic cells and monocyte-derived macrophages	PubMed
	tat	HIV-1 Tat interacts with interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase to influence the rate of translation and protein synthesis in vitro	PubMed
Vpr	vpr	Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpr may antagonize restriction activity of OAS1 against production of infectious wild-type HIV-1	PubMed
Vpu	vpu	Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpu may antagonize restriction activity of OAS1 against production of infectious wild-type HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G60392 (e-PCR)
- UniSTS:137498

RK787_788 (e-PCR)
- UniSTS:12322

D12S2019 (e-PCR)
- UniSTS:16429

RH17491 (e-PCR)
- UniSTS:4674

G12116 (e-PCR)
- UniSTS:39006

RH11156 (e-PCR)
- UniSTS:81019

D12S1960 (e-PCR)
- UniSTS:50366

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 2'-5'-oligoadenylate synthetase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2'-5'-oligoadenylate synthetase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	TAS Traceable Author Statement more info	PubMed
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in antiviral innate immune response	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interferon-alpha	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to virus	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-27-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-27-mediated signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of IP-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral genome replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of viral genome replication	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cellular respiration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monocyte chemotactic protein-1 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein complex oligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ribonuclease activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in surfactant homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor 3 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor 4 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in ribosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 2'-5'-oligoadenylate synthase 1

Names: (2-5')oligo(A) synthase 1; 2',5'-oligo A synthetase 1; 2'-5'-oligoadenylate synthase 1 isoform p42; 2'-5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5'-oligoisoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthetase 1; E16 (2'-5') oligo A synthetase

NP_001027581.1

EC 2.7.7.84

NP_001307080.1

EC 2.7.7.84

NP_001392949.1

EC 2.7.7.84

NP_001392950.1

EC 2.7.7.84

NP_001392951.1

EC 2.7.7.84

NP_001392952.1

EC 2.7.7.84

NP_001392953.1

EC 2.7.7.84

NP_001392954.1

EC 2.7.7.84

NP_001392955.1

EC 2.7.7.84

NP_001392956.1

EC 2.7.7.84

NP_001392958.1

EC 2.7.7.84

NP_001392959.1

EC 2.7.7.84

NP_001399157.1

EC 2.7.7.84

NP_002525.2

EC 2.7.7.84

NP_058132.2

EC 2.7.7.84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011530.2 RefSeqGene

Range

5029..17970

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001032409.3 → NP_001027581.1 2'-5'-oligoadenylate synthase 1 isoform 3

See identical proteins and their annotated locations for NP_001027581.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3 (also known as p48), which has a longer, distinct C-terminus, compared to isoform 1.

Source sequence(s)

AJ629455, AY730628, BF055326, CB112445

Consensus CDS

CCDS31905.1

UniProtKB/TrEMBL

S4R3A5

Related

ENSP00000388001.2, ENST00000445409.7

Conserved Domains (2) summary

cd05400
Location:29 → 211

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:163 → 343

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
NM_001320151.2 → NP_001307080.1 2'-5'-oligoadenylate synthase 1 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) represents the allele encoded by the GRCh38 reference genome, and differs in the 3' coding region and 3' UTR compared to variant 1. It encodes isoform 4 (also known as p44b), which has a shorter, distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA085948, AC004551, AJ629455, CB112445

Consensus CDS

CCDS81742.1

UniProtKB/TrEMBL

A0A7P0T854

Related

ENSP00000448790.1, ENST00000551241.6

Conserved Domains (2) summary

cd05400
Location:29 → 211

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:163 → 343

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
NM_001406020.1 → NP_001392949.1 2'-5'-oligoadenylate synthase 1 isoform 5

Status: REVIEWED

Source sequence(s)

AC004551
NM_001406021.1 → NP_001392950.1 2'-5'-oligoadenylate synthase 1 isoform 6

Status: REVIEWED

Source sequence(s)

AC004551

Consensus CDS

CCDS91755.1

UniProtKB/TrEMBL

A0A7P0Z4N8

Related

ENSP00000506580.1, ENST00000681700.1
NM_001406022.1 → NP_001392951.1 2'-5'-oligoadenylate synthase 1 isoform 7

Status: REVIEWED

Source sequence(s)

AC004551

Consensus CDS

CCDS91752.1

UniProtKB/TrEMBL

H0YIB8

Related

ENSP00000449053.2, ENST00000553152.2
NM_001406023.1 → NP_001392952.1 2'-5'-oligoadenylate synthase 1 isoform 8

Status: REVIEWED

Source sequence(s)

AC004551
NM_001406024.1 → NP_001392953.1 2'-5'-oligoadenylate synthase 1 isoform 9

Status: REVIEWED

Source sequence(s)

AC004551

UniProtKB/TrEMBL

A0A6Q8PHR1

Related

ENSP00000502804.1, ENST00000675868.2
NM_001406025.1 → NP_001392954.1 2'-5'-oligoadenylate synthase 1 isoform 10

Status: REVIEWED

Source sequence(s)

AC004551
NM_001406026.1 → NP_001392955.1 2'-5'-oligoadenylate synthase 1 isoform 11

Status: REVIEWED

Source sequence(s)

AC004551

UniProtKB/TrEMBL

A0A7P0T9Q4

Related

ENSP00000505786.1, ENST00000679971.1
NM_001406027.1 → NP_001392956.1 2'-5'-oligoadenylate synthase 1 isoform 12

Status: REVIEWED

Source sequence(s)

AC004551

UniProtKB/TrEMBL

A0A7P0T8F9

Related

ENSP00000505165.1, ENST00000680455.1
NM_001406029.1 → NP_001392958.1 2'-5'-oligoadenylate synthase 1 isoform 13

Status: REVIEWED

Source sequence(s)

AC004551
NM_001406030.1 → NP_001392959.1 2'-5'-oligoadenylate synthase 1 isoform 14

Status: REVIEWED

Source sequence(s)

AC004551
NM_001412228.1 → NP_001399157.1 2'-5'-oligoadenylate synthase 1 isoform 15

Status: REVIEWED

Description

Transcript Variant: This variant (24) uses the same exon combination as variant 4 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (15) has a frameshifted C-terminus compared to isoform 4.

Source sequence(s)

CP068266
NM_002534.4 → NP_002525.2 2'-5'-oligoadenylate synthase 1 isoform 2

See identical proteins and their annotated locations for NP_002525.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 (also known as E16, p40, or p42), which has a shorter, distinct C-terminus compared to isoform 1.

Source sequence(s)

AC004551, BC061587, BE048946, CB112445

Consensus CDS

CCDS44980.1

UniProtKB/TrEMBL

A0A7P0T854

Related

ENSP00000415721.2, ENST00000452357.7

Conserved Domains (2) summary

cd05400
Location:29 → 211

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:163 → 343

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
NM_016816.4 → NP_058132.2 2'-5'-oligoadenylate synthase 1 isoform 1

See identical proteins and their annotated locations for NP_058132.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. It encodes isoform 1 (also known as E18 and p46). This variant is produced in individuals with a G allele at a polymorphic splice acceptor site in the 3' most intron(PMID:15732009).

Source sequence(s)

AJ629455, AK225384, CB112445

Consensus CDS

CCDS41838.1

UniProtKB/Swiss-Prot

A8K4N8, F8VXY3, P00973, P04820, P29080, P29081, P78485, P78486, Q16700, Q16701, Q1PG42, Q3ZM01, Q53GC5, Q53YA4, Q6A1Z3, Q6IPC6, Q6P7N9, Q96J61

UniProtKB/TrEMBL

A0A7P0TBG0

Related

ENSP00000202917.5, ENST00000202917.10

Conserved Domains (2) summary

cd05400
Location:29 → 211

NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme

pfam10421
Location:163 → 343

OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RNA

NR_175985.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004551
NR_175986.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004551

Related

ENST00000681505.1
NR_175987.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004551
NR_175988.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004551
NR_175989.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004551
NR_175990.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004551

Related

ENST00000680934.1
NR_175991.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004551
NR_175992.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004551

Related

ENST00000680919.1
NR_175993.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004551