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    XPO4 exportin 4 [ Homo sapiens (human) ]

    Gene ID: 64328, updated on 28-Oct-2024

    Summary

    Official Symbol
    XPO4provided by HGNC
    Official Full Name
    exportin 4provided by HGNC
    Primary source
    HGNC:HGNC:17796
    See related
    Ensembl:ENSG00000132953 MIM:611449; AllianceGenome:HGNC:17796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    exp4
    Summary
    XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.0), heart (RPKM 2.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See XPO4 in Genome Data Viewer
    Location:
    13q12.11
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (20777329..20902774, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (19970477..20095920, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21351468..21476913, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5157 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:21290864-21291578 Neighboring gene Sharpr-MPRA regulatory region 1468 Neighboring gene interleukin 17D Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21303728-21304255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21304256-21304782 Neighboring gene EEF1A lysine methyltransferase 1 Neighboring gene RAN pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7426 Neighboring gene uncharacterized LOC124903129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5158 Neighboring gene CCR4-NOT transcription complex subunit 4 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:21513739-21514238 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:21517633-21518209 Neighboring gene long intergenic non-protein coding RNA 367 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with exportin 4 (XPO4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13046, KIAA1721

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear export signal receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372061.1NP_001358990.1  exportin-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356285, AL512652
      UniProtKB/TrEMBL
      Q8IVQ8
    2. NM_022459.5NP_071904.4  exportin-4 isoform 1

      See identical proteins and their annotated locations for NP_071904.4

      Status: VALIDATED

      Source sequence(s)
      AL356285, AL512652
      Consensus CDS
      CCDS41872.1
      UniProtKB/Swiss-Prot
      Q5VUZ5, Q8N3V6, Q9C0E2, Q9H934
      UniProtKB/TrEMBL
      Q8IVQ8
      Related
      ENSP00000255305.6, ENST00000255305.11

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      20777329..20902774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430537.1XP_047286493.1  exportin-4 isoform X1

      UniProtKB/TrEMBL
      Q0VG75
    2. XM_024449394.2XP_024305162.1  exportin-4 isoform X4

      UniProtKB/TrEMBL
      Q8IVQ8
    3. XM_047430539.1XP_047286495.1  exportin-4 isoform X3

    4. XM_047430538.1XP_047286494.1  exportin-4 isoform X3

    5. XM_011535200.3XP_011533502.1  exportin-4 isoform X3

      See identical proteins and their annotated locations for XP_011533502.1

      UniProtKB/TrEMBL
      Q8IVQ8
    6. XM_047430540.1XP_047286496.1  exportin-4 isoform X3

    7. XM_017020705.2XP_016876194.1  exportin-4 isoform X3

      UniProtKB/TrEMBL
      Q8IVQ8
    8. XM_017020704.3XP_016876193.1  exportin-4 isoform X2

      UniProtKB/TrEMBL
      Q8IVQ8
    9. XM_005266504.5XP_005266561.1  exportin-4 isoform X6

      UniProtKB/TrEMBL
      Q8IVQ8
    10. XM_017020706.3XP_016876195.1  exportin-4 isoform X5

      UniProtKB/TrEMBL
      Q8IVQ8
    11. XM_047430541.1XP_047286497.1  exportin-4 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      19970477..20095920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374849.1XP_054230824.1  exportin-4 isoform X1

      UniProtKB/TrEMBL
      Q0VG75
    2. XM_054374856.1XP_054230831.1  exportin-4 isoform X4

    3. XM_054374854.1XP_054230829.1  exportin-4 isoform X3

    4. XM_054374852.1XP_054230827.1  exportin-4 isoform X3

    5. XM_054374851.1XP_054230826.1  exportin-4 isoform X3

    6. XM_054374855.1XP_054230830.1  exportin-4 isoform X3

    7. XM_054374853.1XP_054230828.1  exportin-4 isoform X3

    8. XM_054374850.1XP_054230825.1  exportin-4 isoform X2

    9. XM_054374858.1XP_054230833.1  exportin-4 isoform X6

    10. XM_054374857.1XP_054230832.1  exportin-4 isoform X5

    11. XM_054374859.1XP_054230834.1  exportin-4 isoform X7