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    ZFP37 ZFP37 zinc finger protein [ Homo sapiens (human) ]

    Gene ID: 7539, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZFP37provided by HGNC
    Official Full Name
    ZFP37 zinc finger proteinprovided by HGNC
    Primary source
    HGNC:HGNC:12863
    See related
    Ensembl:ENSG00000136866 MIM:602951; AllianceGenome:HGNC:12863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF906; zfp-37
    Summary
    This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
    Expression
    Ubiquitous expression in ovary (RPKM 3.5), endometrium (RPKM 2.7) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZFP37 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113038377..113056724, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (125191240..125228482, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (115800657..115819004, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene major urinary protein, pseudogene Neighboring gene zinc finger protein 883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:115838681-115839268 Neighboring gene OCT4 hESC enhancer GRCh37_chr9:115846570-115847071 Neighboring gene family with sequence similarity 225 member B Neighboring gene family with sequence similarity 225 member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning, characterization, and chromosomal assignment of the human ortholog of murine Zfp-37, a candidate gene for Nager syndrome. Dreyer SD, et al. Mamm Genome, 1998 Jun. PMID 9585434
    2. The centromeric/nucleolar chromatin protein ZFP-37 may function to specify neuronal nuclear domains. Payen E, et al. J Biol Chem, 1998 Apr 10. PMID 9535899
    3. AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair. Chen Z, et al. Mol Cell Proteomics, 2020 Mar. PMID 31900314, Free PMC Article
    4. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Fujimoto M, et al. Nat Commun, 2022 Jul 29. PMID 35906200, Free PMC Article
    5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ38524

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 37 homolog
    Names
    zinc finger protein homologous to Zfp37 in mouse

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047087.2 RefSeqGene

      Range
      5000..23347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282515.2 → NP_001269444.1  zinc finger protein 37 homolog isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI002852, AI005346, AK301275, AL162588, BC126390, DA738387
      Consensus CDS
      CCDS65110.1
      UniProtKB/Swiss-Prot
      Q9Y6Q3
      Related
      ENSP00000452552.1, ENST00000553380.1
      Conserved Domains (6) summary
      smart00349
      Location:47 → 106
      KRAB; krueppel associated box
      COG5048
      Location:288 → 633
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:450 → 470
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:448 → 470
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:47 → 86
      KRAB; KRAB box
      pfam13465
      Location:462 → 486
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001282518.2 → NP_001269447.1  zinc finger protein 37 homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AI002852, AI005346, AL162588, BC144145
      Consensus CDS
      CCDS65109.1
      UniProtKB/Swiss-Prot
      Q9Y6Q3
      Related
      ENSP00000451310.1, ENST00000555206.5
      Conserved Domains (6) summary
      cd07765
      Location:33 → 72
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:45 → 92
      KRAB; krueppel associated box
      COG5048
      Location:274 → 619
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:436 → 456
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:434 → 456
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:448 → 472
      zf-H2C2_2; Zinc-finger double domain

    3. NM_003408.3 → NP_003399.1  zinc finger protein 37 homolog isoform 3

      See identical proteins and their annotated locations for NP_003399.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AI002852, AI005346, AL162588, BC126390
      Consensus CDS
      CCDS6787.1
      UniProtKB/Swiss-Prot
      A0AVJ9, B4DVX4, G3V3L7, Q5T7Q4, Q9Y6Q3
      Related
      ENSP00000363344.3, ENST00000374227.8
      Conserved Domains (6) summary
      cd07765
      Location:33 → 71
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:42 → 91
      KRAB; krueppel associated box
      COG5048
      Location:273 → 618
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:435 → 455
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:433 → 455
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:447 → 471
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      113038377..113056724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      125191240..125228482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363758.1 → XP_054219733.1  zinc finger protein 37 homolog isoform X2

    2. XM_054363757.1 → XP_054219732.1  zinc finger protein 37 homolog isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6Q3.3 GenPept UniProtKB/Swiss-Prot:Q9Y6Q3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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