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    RNASE6 ribonuclease A family member 6 [ Homo sapiens (human) ]

    Gene ID: 6039, updated on 30-Oct-2024

    Summary

    Official Symbol
    RNASE6provided by HGNC
    Official Full Name
    ribonuclease A family member 6provided by HGNC
    Primary source
    HGNC:HGNC:10048
    See related
    Ensembl:ENSG00000169413 MIM:601981; AllianceGenome:HGNC:10048
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAD1; RNS6; RNasek6
    Summary
    The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]
    Expression
    Broad expression in lymph node (RPKM 33.5), appendix (RPKM 26.6) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RNASE6 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (20781070..20782467)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14978092..14979588)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21249427..21250626)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984671 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:21219442-21220641 Neighboring gene epididymal protein 3A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8094 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:21240614-21241376 Neighboring gene NANOG hESC enhancer GRCh37_chr14:21243094-21243697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8095 Neighboring gene epididymal protein 3B Neighboring gene uncharacterized LOC105370397 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:21281928-21282428 Neighboring gene ribonuclease A family member 1, pancreatic Neighboring gene Sharpr-MPRA regulatory region 8185 Neighboring gene Sharpr-MPRA regulatory region 4676 Neighboring gene MPRA-validated peak2113 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21296219-21297418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:21308316-21308816 Neighboring gene uncharacterized LOC100507513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8097 Neighboring gene ribonuclease A family member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of ribonuclease K6 (RNASE6) in human B cells PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of RNase A ribonuclease k6 (RNASE6) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA nuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ribonuclease K6
    Names
    ribonuclease A D1
    ribonuclease A family member k6
    ribonuclease, RNase A family, k6
    testicular tissue protein Li 166

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005615.5NP_005606.1  ribonuclease K6 precursor

      See identical proteins and their annotated locations for NP_005606.1

      Status: REVIEWED

      Source sequence(s)
      AI151384, BC020848
      Consensus CDS
      CCDS9558.1
      UniProtKB/Swiss-Prot
      Q93091
      UniProtKB/TrEMBL
      Q6IB39
      Related
      ENSP00000302046.2, ENST00000304677.3
      Conserved Domains (1) summary
      pfam00074
      Location:31147
      RnaseA; Pancreatic ribonuclease

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      20781070..20782467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021566.2XP_016877055.1  ribonuclease K6 isoform X1

      UniProtKB/Swiss-Prot
      Q93091
      UniProtKB/TrEMBL
      Q6IB39
      Conserved Domains (1) summary
      pfam00074
      Location:31147
      RnaseA; Pancreatic ribonuclease

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      14978092..14979588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376539.1XP_054232514.1  ribonuclease K6 isoform X1

      UniProtKB/Swiss-Prot
      Q93091
      UniProtKB/TrEMBL
      Q6IB39
    2. XM_054376540.1XP_054232515.1  ribonuclease K6 isoform X1

      UniProtKB/Swiss-Prot
      Q93091
      UniProtKB/TrEMBL
      Q6IB39