PIAS4 protein inhibitor of activated STAT 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PIAS4provided by HGNC
Official Full Name: protein inhibitor of activated STAT 4provided by HGNC
Primary source: HGNC:HGNC:17002
See related: Ensembl:ENSG00000105229 MIM:605989; AllianceGenome:HGNC:17002
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PIASY; Piasg; ZMIZ6; PIAS-gamma
Summary: Enables SUMO ligase activity and ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of protein sumoylation; protein sumoylation; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis (RPKM 14.8), spleen (RPKM 3.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (4007736..4039386)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (3989995..4022498)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (4007734..4039384)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination.
Title: Roles of the SUMO-related enzymes, PIAS1, PIAS4, and RNF4, in DNA double-strand break repair by homologous recombination.
Effect of MiR-210 on the Chemosensitivity of Breast Cancer by Regulating JAK-STAT Signaling Pathway.
Title: Effect of MiR-210 on the Chemosensitivity of Breast Cancer by Regulating JAK-STAT Signaling Pathway.
PIAS4, upregulated in hepatocellular carcinoma, promotes tumorigenicity and metastasis.
Title: PIAS4, upregulated in hepatocellular carcinoma, promotes tumorigenicity and metastasis.
Complex regulation of orphan nuclear receptor Nur77 (Nr4a1) transcriptional activity by SUMO2 and PIASgamma.
Title: Complex regulation of orphan nuclear receptor Nur77 (Nr4a1) transcriptional activity by SUMO2 and PIASγ.
Homeoprotein Msx1-PIASy Interaction Inhibits Angiogenesis.
Title: Homeoprotein Msx1-PIASy Interaction Inhibits Angiogenesis.
Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies.
Title: Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies.
Further definition of the proximal 19p13.3 microdeletion/microduplication syndrome and implication of PIAS4 as the major contributor.
Title: Further definition of the proximal 19p13.3 microdeletion/microduplication syndrome and implication of PIAS4 as the major contributor.
These findings suggest that PIASy binds to MafA through the SAP domain and negatively regulates the insulin gene promoter through a novel SIM1-dependent mechanism.
Title: PIASy is a SUMOylation-independent negative regulator of the insulin transactivator MafA.
PIASy-enhanced accumulation of SUMO1-conjugated proteins may contribute to its inducing effect of autophagy.
Title: Alcohol-induced autophagy via upregulation of PIASy promotes HCV replication in human hepatoma cells.
PIASgamma regulates HNF-1A SUMOylation with functional implications
Title: The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH91112 (e-PCR)
- UniSTS:88872

A004M07 (e-PCR)
- UniSTS:7009

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables SUMO ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables SUMO ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables SUMO transferase activity	EXP Inferred from Experiment more info	PubMed
enables SUMO transferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables SUMO transferase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	TAS Traceable Author Statement more info
involved_in hair follicle development	IEA Inferred from Electronic Annotation more info
involved_in limb epidermis development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to chromatin	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of double-strand break repair via homologous recombination	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein sumoylation	TAS Traceable Author Statement more info
involved_in regulation of mRNA stability	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin D metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of transferase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 SUMO-protein ligase PIAS4

Names: RING-type E3 ubiquitin transferase PIAS4; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein PIASy; protein inhibitor of activated STAT protein gamma; zinc finger, MIZ-type containing 6

NP_056981.2

EC 2.3.2.27

XP_011526362.1

EC 2.3.2.27

XP_016882357.1

EC 2.3.2.27

XP_054177166.1

EC 2.3.2.27

XP_054177167.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015897.4 → NP_056981.2 E3 SUMO-protein ligase PIAS4

See identical proteins and their annotated locations for NP_056981.2

Status: VALIDATED

Source sequence(s)

AC016586

Consensus CDS

CCDS12118.1

UniProtKB/Swiss-Prot

O75926, Q8N2W9, Q96G19, Q9UN16

UniProtKB/TrEMBL

B3KMR4

Related

ENSP00000262971.1, ENST00000262971.3

Conserved Domains (3) summary

smart00513
Location:12 → 46

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam02891
Location:322 → 371

zf-MIZ; MIZ/SP-RING zinc finger

pfam14324
Location:131 → 269

PINIT; PINIT domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

4007736..4039386

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528060.3 → XP_011526362.1 E3 SUMO-protein ligase PIAS4 isoform X1

UniProtKB/TrEMBL

B3KMR4

Conserved Domains (3) summary

smart00513
Location:31 → 65

SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation

pfam02891
Location:341 → 390

zf-MIZ; MIZ/SP-RING zinc finger

pfam14324
Location:150 → 288

PINIT; PINIT domain
XM_017026868.2 → XP_016882357.1 E3 SUMO-protein ligase PIAS4 isoform X2

UniProtKB/TrEMBL

Q05DS6