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    NCOA5 nuclear receptor coactivator 5 [ Homo sapiens (human) ]

    Gene ID: 57727, updated on 28-Oct-2024

    Summary

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    Official Symbol
    NCOA5provided by HGNC
    Official Full Name
    nuclear receptor coactivator 5provided by HGNC
    Primary source
    HGNC:HGNC:15909
    See related
    Ensembl:ENSG00000124160 MIM:616825; AllianceGenome:HGNC:15909
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIA; bA465L10.6
    Summary
    This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in testis (RPKM 19.7), ovary (RPKM 15.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NCOA5 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (46060991..46089962, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47797006..47826000, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44689630..44718601, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44640983-44641493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12969 Neighboring gene SLC12A5 and MMP9 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12971 Neighboring gene matrix metallopeptidase 9 Neighboring gene solute carrier family 12 member 5 Neighboring gene Sharpr-MPRA regulatory region 13245 Neighboring gene Sharpr-MPRA regulatory region 3425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17957 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr20:44717073-44717887 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:44717888-44718701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17960 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:44731180-44731415 Neighboring gene ribosomal protein L13 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17962 Neighboring gene CRISPRi-FlowFISH-validated CD40 regulatory element GRCh37_chr20:44746135-44748232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17965 Neighboring gene CD40 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Knockout of NCOA5 impairs proliferation and migration of hepatocellular carcinoma cells by suppressing epithelial-to-mesenchymal transition. He J, et al. Biochem Biophys Res Commun, 2018 Jun 2. PMID 29626478
    2. Could NCOA5 a novel candidate gene for multiple sclerosis susceptibility? Rustemoglu H, et al. Mol Biol Rep, 2023 Nov. PMID 37817021
    3. NCOA5 is correlated with progression and prognosis in luminal breast cancer. Ye XH, et al. Biochem Biophys Res Commun, 2017 Jan 8. PMID 27847318
    4. Nuclear Receptor Coactivator 5 is Correlated with Progression in Breast Carcinoma. Xia E, et al. Anticancer Agents Med Chem, 2021. PMID 33573580
    5. Analysis of Nuclear Receptor Coactivator 5 (NCOA5) Messenger RNA Expression and rs2903908 Single Nucleotide Polymorphism of NCOA5 in an Egyptian Cohort with Behçet's Disease: A Single-Center Case-control Study. Koptan DMT, et al. Ocul Immunol Inflamm, 2022 Aug. PMID 34255592

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Could NCOA5 a novel candidate gene for multiple sclerosis susceptibility?
      Title: Could NCOA5 a novel candidate gene for multiple sclerosis susceptibility?
    2. NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
      Title: NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
    3. Analysis of Nuclear Receptor Coactivator 5 (NCOA5) Messenger RNA Expression and rs2903908 Single Nucleotide Polymorphism of NCOA5 in an Egyptian Cohort with Behcet's Disease: A Single-Center Case-control Study.
      Title: Analysis of Nuclear Receptor Coactivator 5 (NCOA5) Messenger RNA Expression and rs2903908 Single Nucleotide Polymorphism of NCOA5 in an Egyptian Cohort with Behçet's Disease: A Single-Center Case-control Study.
    4. Nuclear Receptor Coactivator 5 is Correlated with Progression in Breast Carcinoma.
      Title: Nuclear Receptor Coactivator 5 is Correlated with Progression in Breast Carcinoma.
    5. Results found the expression levels of NCOA5 mRNA and protein significantly decreased in cervical cancer (CC) tissues and correlated with poor overall survival. Its upregulation might suppress cancer cell proliferation, migration, and invasion by inactivating NOTCH3 signaling pathway. These findings suggest that NCOA5 acts as a tumor suppressor and represents a potential novel prognostic marker for overall survival in CC.
      Title: Low expression of NCOA5 predicts poor prognosis in human cervical cancer and promotes proliferation, migration, and invasion of cervical cancer cell lines by regulating notch3 signaling pathway.
    6. knockout of NCOA5 can suppress the epithelial - mesenchymal transition (EMT) in hepatocellular carcinoma cells.
      Title: Knockout of NCOA5 impairs proliferation and migration of hepatocellular carcinoma cells by suppressing epithelial-to-mesenchymal transition.
    7. This study provides new insights and evidences that NOCA5 over-expression was significantly correlated with progression and prognosis in luminal breast cancer. However, the precise cellular mechanisms for NOCA5 in luminal breast cancer need to be further explored.
      Title: NCOA5 is correlated with progression and prognosis in luminal breast cancer.
    8. NCOA5 low expression correlates with survival in esophageal squamous cell carcinoma.
      Title: NCOA5 low expression correlates with survival in esophageal squamous cell carcinoma.
    9. suggest that NCOA5 is a haploinsufficient tumor suppressor and that NCOA5 deficiency increases susceptibility to both glucose intolerance and HCC, partially by increasing IL-6 expression
      Title: NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma.
    10. gene polymorphism confers susceptibility to psoriasis in a Southern European population
      Title: A CD40 and an NCOA5 gene polymorphism confer susceptibility to psoriasis in a Southern European population: a case-control study.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor coactivator 5
    Names
    NCoA-5
    coactivator independent of AF-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348148.2 → NP_001335077.1  nuclear receptor coactivator 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL035662, AL162458
      Conserved Domains (1) summary
      COG0124
      Location:81 → 151
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    2. NM_001348149.2 → NP_001335078.1  nuclear receptor coactivator 5 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL035662, AL162458
      Conserved Domains (2) summary
      COG0124
      Location:186 → 256
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      PRK12678
      Location:32 → 118
      PRK12678; transcription termination factor Rho; Provisional

    3. NM_001348150.2 → NP_001335079.1  nuclear receptor coactivator 5 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL035662, AL162458, BC056872, CN369226
      Conserved Domains (1) summary
      COG0124
      Location:123 → 193
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    4. NM_001348151.2 → NP_001335080.1  nuclear receptor coactivator 5 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL035662, AL162458
      Conserved Domains (1) summary
      COG0124
      Location:81 → 151
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

    5. NM_020967.3 → NP_066018.1  nuclear receptor coactivator 5 isoform 1

      See identical proteins and their annotated locations for NP_066018.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF230533, AL035662, AL162458, CN369226
      Consensus CDS
      CCDS13392.1
      UniProtKB/Swiss-Prot
      B2RTV9, E1P5R0, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9, Q9HCD5
      Related
      ENSP00000290231.6, ENST00000290231.11
      Conserved Domains (2) summary
      COG0124
      Location:186 → 256
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      PRK12678
      Location:32 → 135
      PRK12678; transcription termination factor Rho; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      46060991..46089962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      47797006..47826000 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HCD5.2 GenPept UniProtKB/Swiss-Prot:Q9HCD5

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