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    GRID1 glutamate ionotropic receptor delta type subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2894, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GRID1provided by HGNC
    Official Full Name
    glutamate ionotropic receptor delta type subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:4575
    See related
    Ensembl:ENSG00000182771 MIM:610659; AllianceGenome:HGNC:4575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GluD1; GluD1-b
    Summary
    This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]
    Expression
    Biased expression in brain (RPKM 6.7), thyroid (RPKM 3.7) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GRID1 in Genome Data Viewer
    Location:
    10q23.1-q23.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (85599552..86366795, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (86479694..87247328, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (87359309..88126552, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:87252333-87253142 Neighboring gene long intergenic non-protein coding RNA 1520 Neighboring gene uncharacterized LOC105378404 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:87317701-87318900 Neighboring gene RNA, U6 small nuclear 325, pseudogene Neighboring gene GRID1 antisense RNA 1 Neighboring gene RN7SK pseudogene 238 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:87529073-87529574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:87529575-87530074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3682 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:87818313-87818519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:87851089-87851613 Neighboring gene RNA, 5S ribosomal pseudogene 322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:87864301-87864801 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:87894862-87895400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:87938293-87938794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:87938795-87939294 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:87965696-87966220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:87966221-87966744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:87986763-87987262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:87992997-87993662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88021719-88022702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88022703-88023686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88024064-88024564 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17795 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88051161-88051975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88051976-88052790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88057946-88058446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88091551-88092052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88089455-88090419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88092053-88092552 Neighboring gene Sharpr-MPRA regulatory region 9256 Neighboring gene microRNA 346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88122633-88123146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88123147-88123660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2556 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2558 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2559 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88136831-88137373 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2563 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88159531-88160524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88160525-88161518 Neighboring gene uncharacterized LOC124902473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88162319-88162871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3689 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:88183258-88184012 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17841 Neighboring gene Sharpr-MPRA regulatory region 10398 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:88221644-88222250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3691 Neighboring gene RNA, U6 small nuclear 780, pseudogene Neighboring gene WAPL cohesin release factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells. Livide G, et al. Eur J Hum Genet, 2015 Feb. PMID 24916645, Free PMC Article
    2. Glutamate receptor δ 1 (GRID1) genetic variation and brain structure in schizophrenia. Nenadic I, et al. J Psychiatr Res, 2012 Dec. PMID 23017809
    3. Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter. Treutlein J, et al. Schizophr Res, 2009 Jun. PMID 19346103
    4. A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population. Guo SZ, et al. Schizophr Res, 2007 Jul. PMID 17490860
    5. Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family. Yamazaki M, et al. Biochem Biophys Res Commun, 1992 Mar 16. PMID 1372507

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.
      Title: Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.
    2. GRID1 expression is downregulated in both MECP2- and CDKL5-mutated iPS cells and upregulated in neuronal precursors and mature neurons.
      Title: GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells.
    3. GRID1 genotype is related to gray matter variation in prefrontal and anterior thalamic brain areas in healthy subjects, but not in schizophrenia patients, indicating a potential role in thalamo-cortical functioning.
      Title: Glutamate receptor δ 1 (GRID1) genetic variation and brain structure in schizophrenia.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
    6. The results of this study suggested that genetic variants in the GRID1 transcriptional regulatory region may play a role in the etiology of schizophrenia.
      Title: Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter.
    8. results strongly support previously reported association studies, implicating GRID1 in the etiology of schizophrenia
      Title: A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2011-12-21)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2011-12-21)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
    EBI GWAS Catalog
    Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
    EBI GWAS Catalog
    Genetic variants associated with disordered eating.
    EBI GWAS Catalog
    Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
    EBI GWAS Catalog
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    EBI GWAS Catalog
    Genome-wide association study of periodontal pathogen colonization.
    EBI GWAS Catalog
    Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1220

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in social behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor ionotropic, delta-1
    Names
    gluR delta-1 subunit
    glutamate receptor delta-1 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011875.1 RefSeqGene

      Range
      4699..771942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_017551.3 → NP_060021.1  glutamate receptor ionotropic, delta-1 precursor

      See identical proteins and their annotated locations for NP_060021.1

      Status: REVIEWED

      Source sequence(s)
      AB033046, AC022028, AK127168, AK293104, AL844892, DR001156
      Consensus CDS
      CCDS31236.1
      UniProtKB/Swiss-Prot
      B3KXD5, B7Z7L0, Q8IXT3, Q9ULK0
      UniProtKB/TrEMBL
      A8KAN9
      Related
      ENSP00000330148.7, ENST00000327946.12
      Conserved Domains (4) summary
      cd06392
      Location:25 → 423
      PBP1_iGluR_delta_1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the delta1 receptor of an orphan glutamate receptor family
      cd13730
      Location:436 → 806
      PBP2_iGluR_delta_1; The ligand-binding domain of an orphan ionotropic glutamate receptor delta-1, a member of the type 2 periplasmic-binding fold protein superfamily
      pfam00060
      Location:564 → 841
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:41 → 400
      ANF_receptor; Receptor family ligand binding region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      85599552..86366795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425122.1 → XP_047281078.1  glutamate receptor ionotropic, delta-1 isoform X1

    2. XM_047425123.1 → XP_047281079.1  glutamate receptor ionotropic, delta-1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      86479694..87247328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365665.1 → XP_054221640.1  glutamate receptor ionotropic, delta-1 isoform X1

    2. XM_054365666.1 → XP_054221641.1  glutamate receptor ionotropic, delta-1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULK0.2 GenPept UniProtKB/Swiss-Prot:Q9ULK0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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