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    Zswim8 zinc finger, SWIM-type containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361004, updated on 14-Nov-2024

    Summary

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    Symbol
    Zswim8provided by RGD
    Full Name
    zinc finger, SWIM-type containing 8provided by RGD
    Primary source
    RGD:1309414
    See related
    EnsemblRapid:ENSRNOG00000056617 AllianceGenome:RGD:1309414
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309414
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in positive regulation of macromolecule metabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in cytosol. Predicted to be part of Cul2-RING ubiquitin ligase complex and Cul3-RING ubiquitin ligase complex. Orthologous to human ZSWIM8 (zinc finger SWIM-type containing 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 107.9), Lung (RPKM 95.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zswim8 in Genome Data Viewer
    Location:
    15p16
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (3623040..3638748, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (3573780..3589501, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (4006470..4022238, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352872 Neighboring gene calcium/calmodulin-dependent protein kinase II gamma Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of miRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in target-directed miRNA degradation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cullin-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger SWIM domain-containing protein 8
    Names
    zinc finger SWIM domain-containing protein 8-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271275.1 → NP_001258204.1  zinc finger SWIM domain-containing protein 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2K9R0, D4A5A9
      Related
      ENSRNOP00000075092.1, ENSRNOT00000081997.3
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      3623040..3638748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274373.1 → XP_063130443.1  zinc finger SWIM domain-containing protein 8 isoform X9

    2. XM_063274370.1 → XP_063130440.1  zinc finger SWIM domain-containing protein 8 isoform X5

    3. XM_063274369.1 → XP_063130439.1  zinc finger SWIM domain-containing protein 8 isoform X2

    4. XM_008770549.4 → XP_008768771.1  zinc finger SWIM domain-containing protein 8 isoform X4

      UniProtKB/TrEMBL
      D4A5A9
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    5. XM_008770548.4 → XP_008768770.1  zinc finger SWIM domain-containing protein 8 isoform X3

      UniProtKB/TrEMBL
      D4A5A9
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    6. XM_008770546.4 → XP_008768768.1  zinc finger SWIM domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6B124, D4A5A9
      Related
      ENSRNOP00000094531.1, ENSRNOT00000101173.2
      Conserved Domains (1) summary
      cl19527
      Location:131 → 263
      SWIM; SWIM zinc finger

    7. XM_063274371.1 → XP_063130441.1  zinc finger SWIM domain-containing protein 8 isoform X6

    8. XM_063274372.1 → XP_063130442.1  zinc finger SWIM domain-containing protein 8 isoform X7

    9. XM_039093435.2 → XP_038949363.1  zinc finger SWIM domain-containing protein 8 isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version

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