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    Ncam2 neural cell adhesion molecule 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288280, updated on 25-Apr-2024

    Summary

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    Symbol
    Ncam2provided by RGD
    Full Name
    neural cell adhesion molecule 2provided by RGD
    Primary source
    RGD:1303131
    See related
    Ensembl:ENSRNOG00000002126 AllianceGenome:RGD:1303131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ocam; OCAM-GPI
    Summary
    Predicted to enable identical protein binding activity. Involved in axonal fasciculation and sensory perception of smell. Predicted to be located in axon; nuclear body; and plasma membrane. Predicted to be active in neuron projection. Orthologous to human NCAM2 (neural cell adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 225.2) and Testes (RPKM 23.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ncam2 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (33591748..34078788)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (20104974..20592168)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (19669922..20705063)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480954 Neighboring gene poly(rC) binding protein 2, pseudogene 8 Neighboring gene eukaryotic translation elongation factor 1 epsilon-1-like Neighboring gene transmembrane protein 258, pseudogene 5 Neighboring gene uncharacterized LOC134480956

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential expression of the mammalian homologue of fasciclin II during olfactory development in vivo and in vitro. Hamlin JA, et al. J Comp Neurol, 2004 Jun 28. PMID 15174086
    2. Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule. Kulahin N, et al. Structure, 2011 Feb 9. PMID 21300289
    3. Arx homeobox gene is essential for development of mouse olfactory system. Yoshihara S, et al. Development, 2005 Feb. PMID 15677725
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonal fasciculation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    neural cell adhesion molecule 2
    Names
    fasciclin II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203409.2 → NP_981954.2  neural cell adhesion molecule 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      F1M8G9, Q6RKB3
      Related
      ENSRNOP00000002895.7, ENSRNOT00000002895.8
      Conserved Domains (8) summary
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:496 → 588
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:594 → 678
      fn3; Fibronectin type III domain
      pfam13927
      Location:401 → 479
      Ig_3; Immunoglobulin domain
      cd00096
      Location:300 → 305
      Ig; Ig strand A [structural motif]
      cd05866
      Location:21 → 113
      IgI_1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2; member of the I-set of Ig superfamily (IgSF) domains
      cd20970
      Location:209 → 298
      IgI_1_MuSK; agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains
      cl11960
      Location:300 → 397
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      33591748..34078788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088218.2 → XP_038944146.1  neural cell adhesion molecule 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7R3, A6JL49, Q6RKB2
      Related
      ENSRNOP00000074311.2
      Conserved Domains (8) summary
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:496 → 588
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:594 → 678
      fn3; Fibronectin type III domain
      pfam13927
      Location:401 → 479
      Ig_3; Immunoglobulin domain
      cd00096
      Location:300 → 305
      Ig; Ig strand A [structural motif]
      cd05866
      Location:21 → 113
      IgI_1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2; member of the I-set of Ig superfamily (IgSF) domains
      cd20970
      Location:209 → 298
      IgI_1_MuSK; agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains
      cl11960
      Location:300 → 397
      Ig; Immunoglobulin domain

    2. XM_039088217.2 → XP_038944145.1  neural cell adhesion molecule 2 isoform X1

      UniProtKB/TrEMBL
      Q6RKB3
      Conserved Domains (8) summary
      smart00408
      Location:128 → 189
      IGc2; Immunoglobulin C-2 Type
      cd00063
      Location:496 → 586
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:592 → 676
      fn3; Fibronectin type III domain
      pfam13927
      Location:401 → 479
      Ig_3; Immunoglobulin domain
      cd00096
      Location:300 → 305
      Ig; Ig strand A [structural motif]
      cd05866
      Location:21 → 113
      IgI_1_NCAM-2; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2; member of the I-set of Ig superfamily (IgSF) domains
      cd20970
      Location:209 → 298
      IgI_1_MuSK; agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains
      cl11960
      Location:300 → 397
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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