Ints13 integrator complex subunit 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ints13provided by RGD
Official Full Name: integrator complex subunit 13provided by RGD
Primary source: RGD:1592236
See related: EnsemblRapid:ENSRNOG00000001808 AllianceGenome:RGD:1592236
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Asun
Summary: Predicted to be involved in centrosome localization and regulation of mitotic cell cycle. Predicted to act upstream of or within mitotic spindle organization and protein localization to nuclear envelope. Predicted to be located in cytoplasm and nuclear body. Predicted to be part of integrator complex. Orthologous to human INTS13 (integrator complex subunit 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 236.0), Heart (RPKM 163.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (181190438..181222235, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (179459740..179491541, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (180854988..180887095, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AA955382 (e-PCR)
- UniSTS:261067

RH137259 (e-PCR)
- UniSTS:219347

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in centrosome localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within centrosome localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic spindle organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to nuclear envelope	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of integrator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrator complex subunit 13

Names: asunder, spermatogenesis regulator homolog (Drosphila)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109608.1 → NP_001103078.1 integrator complex subunit 13 isoform 2

See identical proteins and their annotated locations for NP_001103078.1

Status: PROVISIONAL

Source sequence(s)

CH473964

UniProtKB/TrEMBL

A6IN19, D4A6N9

Conserved Domains (1) summary

pfam10221
Location:7 → 690

DUF2151; Cell cycle and development regulator
NM_001398932.1 → NP_001385861.1 integrator complex subunit 13 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

D4A6N9

Related

ENSRNOP00000061847.3, ENSRNOT00000065730.3

Conserved Domains (1) summary

pfam10221
Location:4 → 692

DUF2151; Cell cycle and development regulator

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

181190438..181222235 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108388.2 → XP_038964316.1 integrator complex subunit 13 isoform X1

UniProtKB/TrEMBL

A0A8I5ZWB2, A6IN18, D4A6N9

Related

ENSRNOP00000083691.1, ENSRNOT00000118399.2

Conserved Domains (1) summary

pfam10221
Location:4 → 692

DUF2151; Cell cycle and development regulator
XM_063286723.1 → XP_063142793.1 integrator complex subunit 13 isoform X2