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    CD5L CD5 molecule like [ Homo sapiens (human) ]

    Gene ID: 922, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CD5Lprovided by HGNC
    Official Full Name
    CD5 molecule likeprovided by HGNC
    Primary source
    HGNC:HGNC:1690
    See related
    Ensembl:ENSG00000073754 MIM:602592; AllianceGenome:HGNC:1690
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIM; API6; CT-2; hAIM; PRO229; Spalpha; SP-ALPHA
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to act upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward spleen (RPKM 260.3) See more
    Orthologs
    mouse all
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    Genomic context

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    See CD5L in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (157827068..157841808, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156964145..156978876, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157796858..157811598, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Fc receptor like 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:157739405-157740604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1895 Neighboring gene Fc receptor like 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:157838349-157838995 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 2 Neighboring gene Fc receptor like 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Myeloid-specific expression of Api6/AIM/Sp alpha induces systemic inflammation and adenocarcinoma in the lung. Qu P, et al. J Immunol, 2009 Feb 1. PMID 19155514, Free PMC Article
    2. Circulating AIM as an indicator of liver damage and hepatocellular carcinoma in humans. Yamazaki T, et al. PLoS One, 2014. PMID 25302503, Free PMC Article
    3. AIM/CD5L: a key protein in the control of immune homeostasis and inflammatory disease. Sanjurjo L, et al. J Leukoc Biol, 2015 Aug. PMID 26048980
    4. Human scavenger protein AIM increases foam cell formation and CD36-mediated oxLDL uptake. Amézaga N, et al. J Leukoc Biol, 2014 Mar. PMID 24295828
    5. CD5L is upregulated in hepatocellular carcinoma and promotes liver cancer cell proliferation and antiapoptotic responses by binding to HSPA5 (GRP78). Aran G, et al. FASEB J, 2018 Jul. PMID 29465313

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CD5L aggravates rheumatoid arthritis progression via promoting synovial fibroblasts proliferation and activity.
      Title: CD5L aggravates rheumatoid arthritis progression via promoting synovial fibroblasts proliferation and activity.
    2. AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions.
      Title: AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions.
    3. Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD.
      Title: Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD.
    4. The comprehensive role of apoptosis inhibitor of macrophage (AIM) in pathological conditions.
      Title: The comprehensive role of apoptosis inhibitor of macrophage (AIM) in pathological conditions.
    5. [CD5L is elevated in the serum of patients with candidemia and promotes disease progression in mouse models].
      Title: [CD5L is elevated in the serum of patients with candidemia and promotes disease progression in mouse models].
    6. Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators.
      Title: Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators.
    7. CD5L Secreted by Macrophage on Atherosclerosis Progression Based on Lipid Metabolism Induced Inflammatory Damage.
      Title: CD5L Secreted by Macrophage on Atherosclerosis Progression Based on Lipid Metabolism Induced Inflammatory Damage.
    8. Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease.
      Title: Circulating CD5L is associated with cardiovascular events and all-cause mortality in individuals with chronic kidney disease.
    9. The Role of Renal Macrophage, AIM, and TGF-beta1 Expression in Renal Fibrosis Progression in IgAN Patients.
      Title: The Role of Renal Macrophage, AIM, and TGF-β1 Expression in Renal Fibrosis Progression in IgAN Patients.
    10. Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy.
      Title: Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    nucleocapsid gag HIV-1 NC upregulates CD5 molecule-like in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of complement-dependent cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of complement activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zymogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in blood microparticle HDA PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CD5 antigen-like
    Names
    CD5 antigen-like (scavenger receptor cysteine rich family)
    apoptosis inhibitor 6
    apoptosis inhibitor expressed by macrophages
    apoptosis inhibitor of macrophage
    igM-associated peptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347698.2 → NP_001334627.1  CD5 antigen-like isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a distinct C-terminus compard to isoform 1.
      Source sequence(s)
      AL139409, AY358494, DA957550
      UniProtKB/Swiss-Prot
      O43866

    2. NM_005894.3 → NP_005885.1  CD5 antigen-like isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1, which differs only in the last aa compared to isoform 2.
      Source sequence(s)
      AK292040, AL139409, DA957550, U82812
      Consensus CDS
      CCDS1171.1
      UniProtKB/Swiss-Prot
      A8K7M5, O43866, Q6UX63
      Related
      ENSP00000357156.4, ENST00000368174.5
      Conserved Domains (1) summary
      smart00202
      Location:244 → 346
      SR; Scavenger receptor Cys-rich

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      157827068..157841808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002806.2 → XP_016858295.1  CD5 antigen-like isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      156964145..156978876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339616.1 → XP_054195591.1  CD5 antigen-like isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43866.1 GenPept UniProtKB/Swiss-Prot:O43866

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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