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    CLDN15 claudin 15 [ Homo sapiens (human) ]

    Gene ID: 24146, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CLDN15provided by HGNC
    Official Full Name
    claudin 15provided by HGNC
    Primary source
    HGNC:HGNC:2036
    See related
    Ensembl:ENSG00000106404 MIM:615778; AllianceGenome:HGNC:2036
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]
    Expression
    Biased expression in duodenum (RPKM 65.8), small intestine (RPKM 50.2) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CLDN15 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (101232094..101238820, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102555557..102562283, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100875375..100882101, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100859968-100860490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26401 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100861252-100861793 Neighboring gene zinc finger HIT-type containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100870334-100870510 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100874831-100875752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100883201-100883744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26403 Neighboring gene fission, mitochondrial 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100893889-100894842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18482 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100909266-100909443 Neighboring gene RNA, U6 small nuclear 1104, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations. Alberini G, et al. PLoS One, 2017. PMID 28863193, Free PMC Article
    2. Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Colegio OR, et al. Am J Physiol Cell Physiol, 2002 Jul. PMID 12055082
    3. Claudins--key pieces in the tight junction puzzle. Koval M. Cell Commun Adhes, 2006 May-Jun. PMID 16798613
    4. Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells. Takehara M, et al. Biol Pharm Bull, 2009 May. PMID 19420749
    5. Unique structural features of claudin-5 and claudin-15 lead to functionally distinct tight junction strand architecture. Rajagopal N, et al. Ann N Y Acad Sci, 2022 Nov. PMID 36114674

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unique structural features of claudin-5 and claudin-15 lead to functionally distinct tight junction strand architecture.
      Title: Unique structural features of claudin-5 and claudin-15 lead to functionally distinct tight junction strand architecture.
    2. Tight junction channels claudin-10b and claudin-15: Functional mapping of pore-lining residues.
      Title: Tight junction channels claudin-10b and claudin-15: Functional mapping of pore-lining residues.
    3. CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma.
      Title: CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma.
    4. Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease.
      Title: Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease.
    5. analysis of claudin-15 tight junction paracellular architecture by molecular dynamics simulations
      Title: A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations.
    6. Data show that alterations in myosin light chain kinase activity, claudin-15 and claudin-2 expression are associated with gluten-induced symptomatology and intestinal permeability changes in diarrhea-predominant irritable bowel syndrome (IBS-D).
      Title: Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Impact of ancestry and common genetic variants on QT interval in African Americans.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42715, MGC19536

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables paracellular tight junction channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in paracellular transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of intestinal D-glucose absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of intestinal lipid absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in tight junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    claudin-15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185080.2 → NP_001172009.1  claudin-15

      See identical proteins and their annotated locations for NP_001172009.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK056103, DB158141
      Consensus CDS
      CCDS5717.1
      UniProtKB/Swiss-Prot
      B3KPB5, P56746
      Related
      ENSP00000385300.1, ENST00000401528.5
      Conserved Domains (1) summary
      cl21598
      Location:3 → 177
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    2. NM_014343.3 → NP_055158.1  claudin-15

      See identical proteins and their annotated locations for NP_055158.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a shorter and alternate 5' UTR, as compared to variant 1.
      Source sequence(s)
      AJ245738, AK056103
      Consensus CDS
      CCDS5717.1
      UniProtKB/Swiss-Prot
      B3KPB5, P56746
      Related
      ENSP00000308870.5, ENST00000308344.10
      Conserved Domains (1) summary
      cl21598
      Location:3 → 177
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      101232094..101238820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      102555557..102562283 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138429.1: Suppressed sequence

      Description
      NM_138429.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56746.1 GenPept UniProtKB/Swiss-Prot:P56746

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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