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    ZNF12 zinc finger protein 12 [ Homo sapiens (human) ]

    Gene ID: 7559, updated on 3-Nov-2024

    Summary

    Official Symbol
    ZNF12provided by HGNC
    Official Full Name
    zinc finger protein 12provided by HGNC
    Primary source
    HGNC:HGNC:12902
    See related
    Ensembl:ENSG00000164631 MIM:194536; AllianceGenome:HGNC:12902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX3; HZF11; GIOT-3; ZNF325
    Summary
    This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 9.8), endometrium (RPKM 8.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF12 in Genome Data Viewer
    Location:
    7p22.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (6688433..6706947, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6807510..6826041, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6728064..6746578, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:6703791-6704291 Neighboring gene uncharacterized LOC124901583 Neighboring gene zinc finger protein 33B pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:6746247-6746746 Neighboring gene speedy/RINGO cell cycle regulator family member E20, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25633 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:6768255-6769230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17959 Neighboring gene PMS2 C-terminal like (pseudogene)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 12 (ZNF12) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 12
    Names
    gonadotropin inducible transcription repressor 3
    gonadotropin-inducible ovary transcription repressor 3
    zinc finger protein 11
    zinc finger protein 325
    zinc finger protein KOX3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006956.3NP_008887.2  zinc finger protein 12 isoform b

      See identical proteins and their annotated locations for NP_008887.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC073343, AI879099, BC051892, BX114779
      Consensus CDS
      CCDS47539.1
      UniProtKB/Swiss-Prot
      P17014
      Related
      ENSP00000344745.5, ENST00000342651.9
      Conserved Domains (6) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:269645
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:289309
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:539561
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:441466
      zf-H2C2_2; Zinc-finger double domain
    2. NM_016265.4NP_057349.2  zinc finger protein 12 isoform a

      See identical proteins and their annotated locations for NP_057349.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC073343, AF505656, AI879099, BC051892, BX114779
      Consensus CDS
      CCDS47538.1
      UniProtKB/Swiss-Prot
      A8MYC4, A8WFQ8, B2RNQ7, B4DF45, P17014, Q6N016, Q8NHZ0, Q9H9P0, Q9ULZ6
      Related
      ENSP00000385939.1, ENST00000405858.6
      Conserved Domains (6) summary
      smart00349
      Location:868
      KRAB; krueppel associated box
      COG5048
      Location:307683
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:327347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:577599
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:479504
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      6688433..6706947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      6807510..6826041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)