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    PHOSPHO2 phosphatase, orphan 2 [ Homo sapiens (human) ]

    Gene ID: 493911, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PHOSPHO2provided by HGNC
    Official Full Name
    phosphatase, orphan 2provided by HGNC
    Primary source
    HGNC:HGNC:28316
    See related
    Ensembl:ENSG00000144362 AllianceGenome:HGNC:28316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable phosphatase activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 6.7), prostate (RPKM 5.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PHOSPHO2 in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (169694469..169701708)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (170174071..170181317)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170550979..170558218)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase G Neighboring gene MPRA-validated peak3919 silencer Neighboring gene cilia and flagella associated protein 210 Neighboring gene CYFIP related Rac1 interactor B pseudogene Neighboring gene PHOSPHO2-KLHL23 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12082 Neighboring gene uncharacterized LOC124906089 Neighboring gene small nucleolar RNA SNORA51

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. Roberts SJ, et al. Biochim Biophys Acta, 2005 Aug 31. PMID 16054448
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
    3. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
    4. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Readthrough PHOSPHO2-KLHL23

    Readthrough gene: PHOSPHO2-KLHL23, Included gene: KLHL23

    Homology

    Clone Names

    • MGC22679, MGC111048

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables pyridoxal phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyridoxal phosphate phosphatase PHOSPHO2
    NP_001008489.1
    NP_001186214.1
    NP_001186215.1
    NP_001186216.1
    NP_001186217.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008489.4 → NP_001008489.1  pyridoxal phosphate phosphatase PHOSPHO2

      See identical proteins and their annotated locations for NP_001008489.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
      Source sequence(s)
      BC106013
      Consensus CDS
      CCDS33319.1
      UniProtKB/Swiss-Prot
      B2RC30, D3DPC7, Q8TCD6
      Related
      ENSP00000352782.3, ENST00000359744.8
      Conserved Domains (1) summary
      pfam06888
      Location:3 → 239
      Put_Phosphatase; Putative Phosphatase

    2. NM_001199285.2 → NP_001186214.1  pyridoxal phosphate phosphatase PHOSPHO2

      See identical proteins and their annotated locations for NP_001186214.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
      Source sequence(s)
      AK314915, BC106013
      Consensus CDS
      CCDS33319.1
      UniProtKB/Swiss-Prot
      B2RC30, D3DPC7, Q8TCD6
      Conserved Domains (1) summary
      pfam06888
      Location:3 → 239
      Put_Phosphatase; Putative Phosphatase

    3. NM_001199286.2 → NP_001186215.1  pyridoxal phosphate phosphatase PHOSPHO2

      See identical proteins and their annotated locations for NP_001186215.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants (1-5) encode the same protein.
      Source sequence(s)
      BC106013, BI550291, DA211528
      Consensus CDS
      CCDS33319.1
      UniProtKB/Swiss-Prot
      B2RC30, D3DPC7, Q8TCD6
      Related
      ENSP00000481046.1, ENST00000616524.4
      Conserved Domains (1) summary
      pfam06888
      Location:3 → 239
      Put_Phosphatase; Putative Phosphatase

    4. NM_001199287.2 → NP_001186216.1  pyridoxal phosphate phosphatase PHOSPHO2

      See identical proteins and their annotated locations for NP_001186216.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
      Source sequence(s)
      BC106013, BM820383, DA211528
      Consensus CDS
      CCDS33319.1
      UniProtKB/Swiss-Prot
      B2RC30, D3DPC7, Q8TCD6
      Related
      ENSP00000481680.1, ENST00000616481.4
      Conserved Domains (1) summary
      pfam06888
      Location:3 → 239
      Put_Phosphatase; Putative Phosphatase

    5. NM_001199288.2 → NP_001186217.1  pyridoxal phosphate phosphatase PHOSPHO2

      See identical proteins and their annotated locations for NP_001186217.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants (1-5) encode the same protein.
      Source sequence(s)
      BC106013, DA211528, DB443540
      Consensus CDS
      CCDS33319.1
      UniProtKB/Swiss-Prot
      B2RC30, D3DPC7, Q8TCD6
      Related
      ENSP00000481857.1, ENST00000617738.4
      Conserved Domains (1) summary
      pfam06888
      Location:3 → 239
      Put_Phosphatase; Putative Phosphatase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      169694469..169701708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      170174071..170181317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TCD6.1 GenPept UniProtKB/Swiss-Prot:Q8TCD6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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