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    Ifna5 interferon, alpha 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298210, updated on 17-Aug-2024

    Summary

    Official Symbol
    Ifna5provided by RGD
    Official Full Name
    interferon, alpha 5provided by RGD
    Primary source
    RGD:1359312
    See related
    EnsemblRapid:ENSRNOG00000079725 AllianceGenome:RGD:1359312
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ifna1; Ifna1l1; IFN-alpha1
    Summary
    Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Crimean-Congo hemorrhagic fever; common cold; hepatitis B; liver disease (multiple); and sarcoidosis. Orthologous to several human genes including IFNA10 (interferon alpha 10); IFNA14 (interferon alpha 14); and IFNA16 (interferon alpha 16). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    Location:
    5q32
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (108233736..108234314, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (103187852..103188430, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (107039347..107039925, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene interferon, alpha 1 like 1 Neighboring gene interferon alpha-1-like Neighboring gene interferon alpha-1-like

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type I interferon receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in B cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in T cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in humoral immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in natural killer cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to exogenous dsRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    interferon alpha-1
    Names
    interferon-alpha 1
    interferon-alpha 1-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014786.1NP_001014786.1  interferon alpha-1 precursor

      See identical proteins and their annotated locations for NP_001014786.1

      Status: PROVISIONAL

      Source sequence(s)
      X00336
      UniProtKB/Swiss-Prot
      P05011
      Related
      ENSRNOP00000110010.1, ENSRNOT00000145764.1
      Conserved Domains (1) summary
      pfam00143
      Location:32178
      Interferon; Interferon alpha/beta domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      108233736..108234314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)