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    Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305150, updated on 2-Nov-2024

    Summary

    Official Symbol
    Hsd17b13provided by RGD
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 13provided by RGD
    Primary source
    RGD:1359553
    See related
    EnsemblRapid:ENSRNOG00000002212 AllianceGenome:RGD:1359553
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within positive regulation of lipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in lipid droplet. Orthologous to human HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 1223.0) See more
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    Genomic context

    See Hsd17b13 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (6056708..6071463)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5751697..5766809)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (7113544..7128218)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene secretory calcium-binding phosphoprotein proline-glutamine rich 1 Neighboring gene nudix hydrolase 9 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 11 Neighboring gene uncharacterized LOC120096561 Neighboring gene kelch-like family member 8 Neighboring gene ALF transcription elongation factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC108860

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables steroid dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    17-beta-hydroxysteroid dehydrogenase 13
    Names
    17-beta-HSD 13
    hepatic retinol/retinal dehydrogenase
    short-chain dehydrogenase/reductase 9
    NP_001009684.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009684.1NP_001009684.1  17-beta-hydroxysteroid dehydrogenase 13 precursor

      See identical proteins and their annotated locations for NP_001009684.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088191
      UniProtKB/Swiss-Prot
      Q5M875
      UniProtKB/TrEMBL
      A0A8I5ZU34
      Related
      ENSRNOP00000029333.2, ENSRNOT00000038188.4
      Conserved Domains (2) summary
      cd05339
      Location:38277
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      pfam00106
      Location:37228
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      6056708..6071463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005492928.2 RNA Sequence