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    Anapc1 anaphase promoting complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311412, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Anapc1provided by RGD
    Official Full Name
    anaphase promoting complex subunit 1provided by RGD
    Primary source
    RGD:1306629
    See related
    EnsemblRapid:ENSRNOG00000016965 AllianceGenome:RGD:1306629
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein polyubiquitination. Predicted to be located in nucleus. Predicted to be part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 141.0), Lung (RPKM 122.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Anapc1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (136303350..136383464, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (115850117..115930259, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (121147484..121226125, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550367 Neighboring gene speedy/RINGO cell cycle regulator family, member E4C Neighboring gene MER proto-oncogene, tyrosine kinase Neighboring gene transmembrane protein 87B Neighboring gene transfer RNA alanine (anticodon AGC) 45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Fan M, et al. Genes Dev, 2004 Feb 1. PMID 14744933, Free PMC Article
    2. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Jin L, et al. Cell, 2008 May 16. PMID 18485873, Free PMC Article
    3. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Dube P, et al. Mol Cell, 2005 Dec 22. PMID 16364912
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein branched polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein branched polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107771.1 → NP_001101241.1  anaphase-promoting complex subunit 1

      See identical proteins and their annotated locations for NP_001101241.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A0A8I6A4J8, A6HQ36
      Related
      ENSRNOP00000052727.5, ENSRNOT00000055875.5
      Conserved Domains (2) summary
      pfam01851
      Location:1467 → 1501
      PC_rep; Proteasome/cyclosome repeat
      pfam12859
      Location:150 → 206
      ANAPC1; Anaphase-promoting complex subunit 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      136303350..136383464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762177.4 → XP_008760399.1  anaphase-promoting complex subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_008760399.1

      UniProtKB/TrEMBL
      A0A8I6A4J8, A6HQ36
      Conserved Domains (2) summary
      pfam01851
      Location:1467 → 1501
      PC_rep; Proteasome/cyclosome repeat
      pfam12859
      Location:150 → 206
      ANAPC1; Anaphase-promoting complex subunit 1

    2. XM_006234973.5 → XP_006235035.1  anaphase-promoting complex subunit 1 isoform X1

      See identical proteins and their annotated locations for XP_006235035.1

      UniProtKB/TrEMBL
      A0A8I6A4J8, A6HQ36
      Conserved Domains (2) summary
      pfam01851
      Location:1467 → 1501
      PC_rep; Proteasome/cyclosome repeat
      pfam12859
      Location:150 → 206
      ANAPC1; Anaphase-promoting complex subunit 1

    3. XM_063283753.1 → XP_063139823.1  anaphase-promoting complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A3X6
      Related
      ENSRNOP00000085653.1, ENSRNOT00000111998.2
    Nucleotide Protein Strain
    Heading Accession and Version

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