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    Lrrc8c leucine rich repeat containing 8 VRAC subunit C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289443, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Lrrc8cprovided by RGD
    Official Full Name
    leucine rich repeat containing 8 VRAC subunit Cprovided by RGD
    Primary source
    RGD:1306585
    See related
    Ensembl:ENSRNOG00000065000 AllianceGenome:RGD:1306585
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306585
    Summary
    Contributes to volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; cellular response to osmotic stress; and taurine transport. Is integral component of plasma membrane. Part of ion channel complex. Orthologous to human LRRC8C (leucine rich repeat containing 8 VRAC subunit C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 68.6), Thymus (RPKM 58.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc8c in Genome Data Viewer
    Location:
    14p22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (4528721..4621259, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (4223901..4315590, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (5283655..5378738, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096556 Neighboring gene leucine rich repeat containing 8 VRAC subunit D Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene uncharacterized LOC108352696 Neighboring gene leucine rich repeat containing 8 VRAC subunit B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular composition and heterogeneity of the LRRC8-containing swelling-activated osmolyte channels in primary rat astrocytes. Schober AL, et al. J Physiol, 2017 Nov 15. PMID 28833202, Free PMC Article
    2. Structure of a volume-regulated anion channel of the LRRC8 family. Deneka D, et al. Nature, 2018 Jun. PMID 29769723
    3. The novel gene fad158, having a transmembrane domain and leucine-rich repeat, stimulates adipocyte differentiation. Tominaga K, et al. J Biol Chem, 2004 Aug 13. PMID 15184384
    4. LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength. Syeda R, et al. Cell, 2016 Jan 28. PMID 26824658, Free PMC Article
    5. Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Voss FK, et al. Science, 2014 May 9. PMID 24790029

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112653

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to volume-sensitive anion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to volume-sensitive anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables volume-sensitive anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to volume-sensitive anion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables volume-sensitive anion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in aspartate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aspartate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic anion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic anion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic anion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein hexamerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein hexamerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in taurine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of monoatomic ion channel complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of monoatomic ion channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of monoatomic ion channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    volume-regulated anion channel subunit LRRC8C
    Names
    leucine rich repeat containing 8 family, member C
    leucine-rich repeat-containing protein 8C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037179.1 → NP_001032256.1  volume-regulated anion channel subunit LRRC8C

      See identical proteins and their annotated locations for NP_001032256.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100076
      UniProtKB/Swiss-Prot
      Q498T9
      Related
      ENSRNOP00000082962.1, ENSRNOT00000104559.1
      Conserved Domains (4) summary
      cd00116
      Location:590 → 695
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:469 → 492
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 338
      Pannexin_like; Pannexin-like TM region of LRRC8
      pfam13855
      Location:589 → 649
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      4528721..4621259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250542.5 → XP_006250604.1  volume-regulated anion channel subunit LRRC8C isoform X1

      See identical proteins and their annotated locations for XP_006250604.1

      UniProtKB/Swiss-Prot
      Q498T9
      Conserved Domains (4) summary
      cd00116
      Location:590 → 695
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:469 → 492
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1 → 338
      Pannexin_like; Pannexin-like TM region of LRRC8
      pfam13855
      Location:589 → 649
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q498T9.1 GenPept UniProtKB/Swiss-Prot:Q498T9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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