Nlrp3 NLR family, pyrin domain containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nlrp3provided by RGD
Official Full Name: NLR family, pyrin domain containing 3provided by RGD
Primary source: RGD:1308314
See related: EnsemblRapid:ENSRNOG00000003170 AllianceGenome:RGD:1308314
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cias1
Summary: Predicted to enable several functions, including ATP hydrolysis activity; adenyl ribonucleotide binding activity; and cysteine-type endopeptidase activator activity. Involved in leukocyte migration involved in inflammatory response; response to ethanol; and response to organic cyclic compound. Predicted to be located in several cellular components, including Golgi membrane; interphase microtubule organizing center; and mitochondrion. Predicted to be part of NLRP3 inflammasome complex. Predicted to be active in cytosol and membrane. Biomarker of alcoholic hepatitis and myocardial infarction. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 82.9), Lung (RPKM 27.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (44826299..44853373)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (44326770..44353814)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (45884324..45918290)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cystatin C Attenuates Perihematomal Secondary Brain Injury by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway in a Rat Model of Intracerebral Hemorrhage.
Title: Cystatin C Attenuates Perihematomal Secondary Brain Injury by Inhibiting the Cathepsin B/NLRP3 Signaling Pathway in a Rat Model of Intracerebral Hemorrhage.
Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes.
Title: Interference with GPR4 inactivates NLRP3 inflammasome signaling by inhibiting LPAR1 expression to ameliorate oxygen-glucose deprivation/reoxygenation-induced inflammation and apoptosis of cardiomyocytes.
Transcription factor YY1 accelerates hepatic fibrosis development by activating NLRP3 inflammasome-mediated pyroptosis.
Title: Transcription factor YY1 accelerates hepatic fibrosis development by activating NLRP3 inflammasome-mediated pyroptosis.
Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis.
Title: Involvement of oxidative stress-AMPK-Cx43-NLRP3 pathway in extracellular matrix remodeling of gastric smooth muscle cells in rats with diabetic gastroparesis.
The involvement of oxidative stress and the TLR4/NF-kappaB/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia.
Title: The involvement of oxidative stress and the TLR4/NF-κB/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia.
Activation of the Nrf2/ARE signaling pathway ameliorates hyperlipidemia-induced renal tubular epithelial cell injury by inhibiting mtROS-mediated NLRP3 inflammasome activation.
Title: Activation of the Nrf2/ARE signaling pathway ameliorates hyperlipidemia-induced renal tubular epithelial cell injury by inhibiting mtROS-mediated NLRP3 inflammasome activation.
25-hydroxycholesterol aggravates oxygen-glucose deprivation/reoxygenation-induced pyroptosis through promoting activation of NLRP3 inflammasome in H9C2 cardiomyocytes.
Title: 25-hydroxycholesterol aggravates oxygen-glucose deprivation/reoxygenation-induced pyroptosis through promoting activation of NLRP3 inflammasome in H9C2 cardiomyocytes.
MicroRNA-7 attenuates secondary brain injury following experimental intracerebral hemorrhage via inhibition of NLRP3.
Title: MicroRNA-7 attenuates secondary brain injury following experimental intracerebral hemorrhage via inhibition of NLRP3.
CXCL13/CXCR5 promote chronic postsurgical pain and astrocyte activation in rats by targeting NLRP3.
Title: CXCL13/CXCR5 promote chronic postsurgical pain and astrocyte activation in rats by targeting NLRP3.
NLRP3/miR-223-3p axis attenuates neuroinflammation induced by chronic intermittent hypoxia.
Title: NLRP3/miR-223-3p axis attenuates neuroinflammation induced by chronic intermittent hypoxia.

Submit: New GeneRIF Correction See all GeneRIFs (211)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ADP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables molecular sensor activity	ISO Inferred from Sequence Orthology more info
enables molecular sensor activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptidoglycan	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in detection of biotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in detection of biotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration involved in inflammatory response	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 2 cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
part_of NLRP3 inflammasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NLRP3 inflammasome complex	ISO Inferred from Sequence Orthology more info
part_of canonical inflammasome complex	IEA Inferred from Electronic Annotation more info
part_of canonical inflammasome complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in interphase microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in interphase microtubule organizing center	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NACHT, LRR and PYD domains-containing protein 3

Names: PYRIN-containing APAF1-like protein 1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 protein homolog; cryopyrin; mast cell maturation-associated-inducible protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191642.1 → NP_001178571.1 NACHT, LRR and PYD domains-containing protein 3

See identical proteins and their annotated locations for NP_001178571.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

D4A523

Related

ENSRNOP00000004280.3, ENSRNOT00000004280.7

Conserved Domains (7) summary

smart00368
Location:967 → 994

LRR_RI; Leucine rich repeat, ribonuclease inhibitor type

cd00116
Location:575 → 952

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08320
Location:10 → 90

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:742 → 770

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:218 → 387

NACHT; NACHT domain

pfam14484
Location:138 → 207

FISNA; Fish-specific NACHT associated domain

pfam17779
Location:466 → 518

NOD2_WH; NOD2 winged helix domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

44826299..44853373

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268610.1 → XP_063124680.1 NACHT, LRR and PYD domains-containing protein 3 isoform X4
XM_063268609.1 → XP_063124679.1 NACHT, LRR and PYD domains-containing protein 3 isoform X3

UniProtKB/TrEMBL

A0A0G2K391

Related

ENSRNOP00000072545.2, ENSRNOT00000086710.3
XM_006246453.5 → XP_006246515.1 NACHT, LRR and PYD domains-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006246515.1

UniProtKB/Swiss-Prot

D4A523

Conserved Domains (7) summary

smart00368
Location:967 → 994

LRR_RI; Leucine rich repeat, ribonuclease inhibitor type

cd00116
Location:575 → 952

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08320
Location:10 → 90

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:742 → 770

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:218 → 387

NACHT; NACHT domain

pfam14484
Location:138 → 207

FISNA; Fish-specific NACHT associated domain

pfam17779
Location:466 → 518

NOD2_WH; NOD2 winged helix domain
XM_063268608.1 → XP_063124678.1 NACHT, LRR and PYD domains-containing protein 3 isoform X1

UniProtKB/Swiss-Prot

D4A523
XM_039085394.2 → XP_038941322.1 NACHT, LRR and PYD domains-containing protein 3 isoform X1

UniProtKB/Swiss-Prot

D4A523

Conserved Domains (7) summary

smart00368
Location:967 → 994

LRR_RI; Leucine rich repeat, ribonuclease inhibitor type

cd00116
Location:575 → 952

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08320
Location:10 → 90

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:742 → 770

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:218 → 387

NACHT; NACHT domain

pfam14484
Location:138 → 207

FISNA; Fish-specific NACHT associated domain

pfam17779
Location:466 → 518

NOD2_WH; NOD2 winged helix domain
XM_039085395.2 → XP_038941323.1 NACHT, LRR and PYD domains-containing protein 3 isoform X1

UniProtKB/Swiss-Prot

D4A523

Conserved Domains (7) summary

smart00368
Location:967 → 994

LRR_RI; Leucine rich repeat, ribonuclease inhibitor type

cd00116
Location:575 → 952

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08320
Location:10 → 90

Pyrin_NALPs; Pyrin death domain found in NALP proteins

sd00033
Location:742 → 770

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:218 → 387

NACHT; NACHT domain

pfam14484
Location:138 → 207

FISNA; Fish-specific NACHT associated domain

pfam17779
Location:466 → 518

NOD2_WH; NOD2 winged helix domain
XM_006246455.5 → XP_006246517.1 NACHT, LRR and PYD domains-containing protein 3 isoform X2

Conserved Domains (6) summary

smart00368
Location:947 → 974

LRR_RI; Leucine rich repeat, ribonuclease inhibitor type

cd00116
Location:575 → 932

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:742 → 776

LRR_RI; leucine-rich repeat [structural motif]

pfam02758
Location:8 → 88

PYRIN; PAAD/DAPIN/Pyrin domain

pfam05729
Location:218 → 387

NACHT; NACHT domain

pfam14484
Location:138 → 207

FISNA; Fish-specific NACHT associated domain
XM_006246457.5 → XP_006246519.1 NACHT, LRR and PYD domains-containing protein 3 isoform X4

Conserved Domains (6) summary

COG4886
Location:738 → 921

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:575 → 940

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:742 → 770

LRR_RI; leucine-rich repeat [structural motif]

pfam02758
Location:8 → 88

PYRIN; PAAD/DAPIN/Pyrin domain

pfam05729
Location:218 → 387

NACHT; NACHT domain

pfam14484
Location:138 → 207

FISNA; Fish-specific NACHT associated domain
XM_039085397.2 → XP_038941325.1 NACHT, LRR and PYD domains-containing protein 3 isoform X5

Conserved Domains (5) summary

cd08320
Location:10 → 90

Pyrin_NALPs; Pyrin death domain found in NALP proteins

pfam05729
Location:218 → 387

NACHT; NACHT domain

pfam14484
Location:138 → 207

FISNA; Fish-specific NACHT associated domain

pfam17779
Location:466 → 518

NOD2_WH; NOD2 winged helix domain

cl39015
Location:575 → 785

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...