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    Mff mitochondrial fission factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301563, updated on 9-Jul-2024

    Summary

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    Symbol
    Mffprovided by RGD
    Full Name
    mitochondrial fission factorprovided by RGD
    Primary source
    RGD:1310230
    See related
    Ensembl:ENSRNOG00000015428 AllianceGenome:RGD:1310230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310230
    Summary
    Enables GTPase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of cardiac muscle cell apoptotic process; and positive regulation of cellular component organization. Located in synaptic vesicle. Colocalizes with mitochondrial membrane and synaptic vesicle membrane. Used to study transient cerebral ischemia. Orthologous to human MFF (mitochondrial fission factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 645.3), Muscle (RPKM 505.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mff in Genome Data Viewer
    Location:
    9q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (91455931..91484171)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (84007798..84036039)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (88490280..88518517)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094721 Neighboring gene collagen type IV alpha 4 chain Neighboring gene collagen type IV alpha 3 chain Neighboring gene uncharacterized LOC120094722 Neighboring gene small cysteine and glycine repeat-containing protein 6-like Neighboring gene transmembrane 4 L six family member 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition. Zhang XM, et al. Neurochem Int, 2015 Nov. PMID 26116440
    2. miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor. Long B, et al. Free Radic Biol Med, 2013 Dec. PMID 23867156, Free PMC Article
    3. A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Lee J, et al. Endocrinology, 2018 Sep 1. PMID 30059978, Free PMC Article
    4. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Gandre-Babbe S, et al. Mol Biol Cell, 2008 Jun. PMID 18353969, Free PMC Article
    5. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Li H, et al. Nat Cell Biol, 2013 Jul. PMID 23792689, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC112646

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial fragmentation involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial fragmentation involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitochondrial fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial fission factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039015.2 → NP_001034104.1  mitochondrial fission factor isoform 2

      See identical proteins and their annotated locations for NP_001034104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BC098682, FN804971, JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q4KM98
      UniProtKB/TrEMBL
      A6JWA8
      Conserved Domains (1) summary
      pfam05644
      Location:1 → 218
      Miff; Mitochondrial and peroxisomal fission factor Mff

    2. NM_001271284.1 → NP_001258213.1  mitochondrial fission factor isoform 1

      See identical proteins and their annotated locations for NP_001258213.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC098682, FM107137, FN804971, JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K8F3, A0A0G2KAL9, A6JWA5
      Conserved Domains (1) summary
      pfam05644
      Location:1 → 291
      Miff; Mitochondrial and peroxisomal fission factor Mff

    3. NM_001276401.1 → NP_001263330.1  mitochondrial fission factor isoform 3

      See identical proteins and their annotated locations for NP_001263330.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, contains an alternate exon in the 5' coding region, and lacks two in-frame exons, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (3) is shorter than isoform 1 and has a distinct, longer N-terminus.
      Source sequence(s)
      BC098682, FN804971, JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0H2UHM6
      Related
      ENSRNOP00000020705.3, ENSRNOT00000020705.7
      Conserved Domains (1) summary
      pfam05644
      Location:27 → 244
      Miff; Mitochondrial and peroxisomal fission factor Mff

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      91455931..91484171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245195.3 → XP_006245257.2  mitochondrial fission factor isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAL9, A0A8I6A6Z1
      Conserved Domains (1) summary
      pfam05644
      Location:1 → 327
      Miff; Mitochondrial and peroxisomal fission factor Mff

    2. XM_006245197.4 → XP_006245259.2  mitochondrial fission factor isoform X2

      UniProtKB/TrEMBL
      A0A0G2KAL9, A0A8I5ZW06

    3. XM_063267011.1 → XP_063123081.1  mitochondrial fission factor isoform X4

      UniProtKB/TrEMBL
      A0A0G2KAL9

    4. XM_039083388.2 → XP_038939316.1  mitochondrial fission factor isoform X6

      UniProtKB/TrEMBL
      A0A0G2KAL9
      Conserved Domains (1) summary
      pfam05644
      Location:1 → 288
      Miff; Mitochondrial and peroxisomal fission factor Mff

    5. XM_039083389.2 → XP_038939317.1  mitochondrial fission factor isoform X7

      Conserved Domains (1) summary
      pfam05644
      Location:1 → 277
      Miff; Mitochondrial and peroxisomal fission factor Mff

    6. XM_039083392.2 → XP_038939320.1  mitochondrial fission factor isoform X14

      Conserved Domains (1) summary
      pfam05644
      Location:1 → 257
      Miff; Mitochondrial and peroxisomal fission factor Mff

    7. XM_006245201.3 → XP_006245263.2  mitochondrial fission factor isoform X8

    8. XM_006245205.4 → XP_006245267.2  mitochondrial fission factor isoform X11

    9. XM_006245208.4 → XP_006245270.2  mitochondrial fission factor isoform X18

      UniProtKB/TrEMBL
      A0A8I6AEV1
      Related
      ENSRNOP00000080210.2, ENSRNOT00000117981.2

    10. XM_006245198.4 → XP_006245260.2  mitochondrial fission factor isoform X3

      UniProtKB/TrEMBL
      A0A0G2KAL9

    11. XM_006245200.4 → XP_006245262.2  mitochondrial fission factor isoform X5

      UniProtKB/TrEMBL
      A0A0G2K8F3, A0A0G2KAL9, A6JWA5
      Conserved Domains (1) summary
      pfam05644
      Location:1 → 291
      Miff; Mitochondrial and peroxisomal fission factor Mff

    12. XM_006245204.4 → XP_006245266.2  mitochondrial fission factor isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZSJ8, A6JWA6
      Conserved Domains (1) summary
      pfam05644
      Location:1 → 271
      Miff; Mitochondrial and peroxisomal fission factor Mff

    13. XM_039083391.2 → XP_038939319.1  mitochondrial fission factor isoform X12

      Conserved Domains (1) summary
      pfam05644
      Location:1 → 263
      Miff; Mitochondrial and peroxisomal fission factor Mff

    14. XM_039083393.2 → XP_038939321.1  mitochondrial fission factor isoform X15

      Conserved Domains (1) summary
      pfam05644
      Location:1 → 252
      Miff; Mitochondrial and peroxisomal fission factor Mff

    15. XM_039083398.2 → XP_038939326.1  mitochondrial fission factor isoform X21

      Conserved Domains (1) summary
      pfam05644
      Location:1 → 232
      Miff; Mitochondrial and peroxisomal fission factor Mff

    16. XM_039083395.2 → XP_038939323.1  mitochondrial fission factor isoform X16

      Conserved Domains (1) summary
      pfam05644
      Location:1 → 249
      Miff; Mitochondrial and peroxisomal fission factor Mff

    17. XM_006245209.4 → XP_006245271.2  mitochondrial fission factor isoform X19

      UniProtKB/TrEMBL
      A0A140TAC2, A6JWA7
      Conserved Domains (1) summary
      pfam05644
      Location:1 → 238
      Miff; Mitochondrial and peroxisomal fission factor Mff

    18. XM_006245211.4 → XP_006245273.2  mitochondrial fission factor isoform X22

      UniProtKB/Swiss-Prot
      Q4KM98
      UniProtKB/TrEMBL
      A6JWA8
      Conserved Domains (1) summary
      pfam05644
      Location:1 → 218
      Miff; Mitochondrial and peroxisomal fission factor Mff

    19. XM_063267019.1 → XP_063123089.1  mitochondrial fission factor isoform X25

    20. XM_063267014.1 → XP_063123084.1  mitochondrial fission factor isoform X10

      UniProtKB/TrEMBL
      A0A0G2K2M2, A0A0G2KAL9
      Related
      ENSRNOP00000072300.1, ENSRNOT00000089142.3

    21. XM_006245206.3 → XP_006245268.1  mitochondrial fission factor isoform X13

      See identical proteins and their annotated locations for XP_006245268.1

      UniProtKB/TrEMBL
      A0A0G2KAL9
      Related
      ENSRNOP00000081902.2, ENSRNOT00000096027.2
      Conserved Domains (1) summary
      pfam05644
      Location:27 → 342
      Miff; Mitochondrial and peroxisomal fission factor Mff

    22. XM_063267015.1 → XP_063123085.1  mitochondrial fission factor isoform X17

      UniProtKB/TrEMBL
      A0A0G2KAL9
      Related
      ENSRNOP00000074586.2, ENSRNOT00000077859.3

    23. XM_039083397.2 → XP_038939325.1  mitochondrial fission factor isoform X20

      UniProtKB/TrEMBL
      A0A0G2KAL9
      Conserved Domains (1) summary
      pfam05644
      Location:27 → 317
      Miff; Mitochondrial and peroxisomal fission factor Mff

    24. XM_063267017.1 → XP_063123087.1  mitochondrial fission factor isoform X23

      Related
      ENSRNOP00000089302.2, ENSRNOT00000100485.2

    25. XM_063267016.1 → XP_063123086.1  mitochondrial fission factor isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAL9, A0A8I6A6Z1

    26. XM_063267018.1 → XP_063123088.1  mitochondrial fission factor isoform X24

      UniProtKB/TrEMBL
      A0A8I6ADD2, A6JWA4
      Related
      ENSRNOP00000091256.1, ENSRNOT00000107482.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KM98.1 GenPept UniProtKB/Swiss-Prot:Q4KM98

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