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    Wdr47 WD repeat domain 47 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310785, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Wdr47provided by RGD
    Official Full Name
    WD repeat domain 47provided by RGD
    Primary source
    RGD:1309181
    See related
    EnsemblRapid:ENSRNOG00000020330 AllianceGenome:RGD:1309181
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309181
    Summary
    Predicted to act upstream of or within several processes, including detection of hot stimulus involved in thermoception; neuronal stem cell population maintenance; and telencephalon development. Located in cytoplasm. Orthologous to human WDR47 (WD repeat domain 47). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 257.3), Testes (RPKM 79.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr47 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198914977..198975844)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (196226757..196287739)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (211380894..211441817)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 167B Neighboring gene TATA-box binding protein associated factor 13 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene chloride channel CLIC-like 1 Neighboring gene G-protein signaling modulator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. WDR47 protects neuronal microtubule minus ends from katanin-mediated severing. Buijs RR, et al. Cell Rep, 2021 Jul 13. PMID 34260930
    2. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Kannan M, et al. Proc Natl Acad Sci U S A, 2017 Oct 31. PMID 29078390, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WDR47 protects neuronal microtubule minus ends from katanin-mediated severing.
      Title: WDR47 protects neuronal microtubule minus ends from katanin-mediated severing.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within anterior commissure morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebral cortex radial glia-guided migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within corpus callosum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within detection of hot stimulus involved in thermoception ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within motor behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuronal stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 47

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100702.1 → NP_001094172.1  WD repeat-containing protein 47

      See identical proteins and their annotated locations for NP_001094172.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473952
      UniProtKB/TrEMBL
      A0A8I5Y1M2, A6HV14, G3V9M3
      Conserved Domains (5) summary
      smart00667
      Location:9 → 42
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:45 → 102
      CTLH; C-terminal to LisH motif
      COG2319
      Location:547 → 920
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:601 → 917
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:613 → 661
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      198914977..198975844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233155.5 → XP_006233217.1  WD repeat-containing protein 47 isoform X5

      See identical proteins and their annotated locations for XP_006233217.1

      UniProtKB/TrEMBL
      A0A8I5Y1M2
      Related
      ENSRNOP00000052715.3, ENSRNOT00000055862.4
      Conserved Domains (5) summary
      smart00667
      Location:9 → 42
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:45 → 102
      CTLH; C-terminal to LisH motif
      COG2319
      Location:554 → 927
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:608 → 924
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:620 → 668
      7WD40; WD40 repeat [structural motif]

    2. XM_063281931.1 → XP_063138001.1  WD repeat-containing protein 47 isoform X8

    3. XM_063281928.1 → XP_063137998.1  WD repeat-containing protein 47 isoform X5

    4. XM_063281924.1 → XP_063137994.1  WD repeat-containing protein 47 isoform X2

    5. XM_063281923.1 → XP_063137993.1  WD repeat-containing protein 47 isoform X1

    6. XM_063281926.1 → XP_063137996.1  WD repeat-containing protein 47 isoform X4

    7. XM_063281925.1 → XP_063137995.1  WD repeat-containing protein 47 isoform X3

    8. XM_063281927.1 → XP_063137997.1  WD repeat-containing protein 47 isoform X5

    9. XM_063281929.1 → XP_063137999.1  WD repeat-containing protein 47 isoform X6

      UniProtKB/TrEMBL
      A6HV14, G3V9M3
      Related
      ENSRNOP00000077485.2, ENSRNOT00000105849.2

    10. XM_063281930.1 → XP_063138000.1  WD repeat-containing protein 47 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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