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    AUS1 ATP-binding cassette sterol transporter AUS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854175, updated on 28-Oct-2024

    Summary

    Official Symbol
    AUS1
    Official Full Name
    ATP-binding cassette sterol transporter AUS1
    Primary source
    SGD:S000005537
    Locus tag
    YOR011W
    See related
    AllianceGenome:SGD:S000005537; FungiDB:YOR011W; VEuPathDB:YOR011W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ABC-type sterol transporter activity. Involved in sterol import. Located in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

    See AUS1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (349679..353863)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tir4p Neighboring gene putative GPI-anchored mannoprotein Neighboring gene tRNA-Thr Neighboring gene uncharacterized protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type sterol transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in sterol import IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in sterol import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP-binding cassette sterol transporter AUS1
    NP_014654.1
    • Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      349679..353863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183430.1NP_014654.1  TPA: ATP-binding cassette sterol transporter AUS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014654.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W278, O94147, Q08409
      UniProtKB/TrEMBL
      C7GLE3, C8ZHX6
      Conserved Domains (1) summary
      TIGR00956
      Location:561369
      3a01205; Pleiotropic Drug Resistance (PDR) Family protein