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    HSH49 U2 snRNP complex subunit HSH49 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854497, updated on 28-Oct-2024

    Summary

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    Official Symbol
    HSH49
    Official Full Name
    U2 snRNP complex subunit HSH49
    Primary source
    SGD:S000005846
    Locus tag
    YOR319W
    See related
    AllianceGenome:SGD:S000005846; FungiDB:YOR319W; VEuPathDB:YOR319W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Part of U2 snRNP and U2-type prespliceosome. Human ortholog(s) of this gene implicated in Nager acrofacial dysostosis; cervical cancer; and hepatocellular carcinoma. Orthologous to human SF3B4 (splicing factor 3b subunit 4). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See HSH49 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (912822..913463)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long-chain fatty acid-CoA ligase FAA1 Neighboring gene glucose N-acetyltransferase Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain. van Roon AM, et al. RNA, 2017 Jun. PMID 28348170, Free PMC Article
    2. Conservation of structure and subunit interactions in yeast homologues of splicing factor 3b (SF3b) subunits. Igel H, et al. RNA, 1998 Jan. PMID 9436903, Free PMC Article
    3. Selective aggregation of the splicing factor Hsh155 suppresses splicing upon genotoxic stress. Mathew V, et al. J Cell Biol, 2017 Dec 4. PMID 28978642, Free PMC Article
    4. CUS1, a suppressor of cold-sensitive U2 snRNA mutations, is a novel yeast splicing factor homologous to human SAP 145. Wells SE, et al. Genes Dev, 1996 Jan 15. PMID 8566755
    5. Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA. Pauling MH, et al. Mol Cell Biol, 2000 Mar. PMID 10688664, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U2 snRNP complex subunit HSH49
    NP_014964.1
    • U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      912822..913463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183739.1 → NP_014964.1  TPA: U2 snRNP complex subunit HSH49 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014964.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W317, Q99181
      UniProtKB/TrEMBL
      A6ZPF2, B3LJY2, B5VSJ3, C7GNU4, C8ZH70, G2WNI4, N1NW79
      Conserved Domains (2) summary
      TIGR01628
      Location:10 → 208
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12334
      Location:11 → 85
      RRM1_SF3B4; RNA recognition motif 1 (RRM1) found in splicing factor 3B subunit 4 (SF3B4) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99181.1

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