UMP1 Ump1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: UMP1
Official Full Name: Ump1p
Primary source: SGD:S000000377
Locus tag: YBR173C
See related: AllianceGenome:SGD:S000000377; FungiDB:YBR173C; VEuPathDB:YBR173C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RNS2
Summary: Involved in DNA damage response; proteasome assembly; and ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 2. Orthologous to human POMP (proteasome maturation protein). [provided by Alliance of Genome Resources, Oct 2024]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Structural roles of Ump1 and beta-subunit propeptides in proteasome biogenesis.
Title: Structural roles of Ump1 and β-subunit propeptides in proteasome biogenesis.
Interaction with the Assembly Chaperone Ump1 Promotes Incorporation of the beta7 Subunit into Half-Proteasome Precursor Complexes Driving Their Dimerization.
Title: Interaction with the Assembly Chaperone Ump1 Promotes Incorporation of the β7 Subunit into Half-Proteasome Precursor Complexes Driving Their Dimerization.
Ump1 and Pba1-Pba2 promote efficient biogenesis of 20S proteasome core particles from its subunits via 15S intermediates
Title: Proteasome assembly from 15S precursors involves major conformational changes and recycling of the Pba1-Pba2 chaperone.
The specificity of the mutator effect caused by ump1 is discussed in light of the proposed role of 26S proteasome activity in the regulation of postreplication DNA repair.
Title: The spectrum of spontaneous mutations caused by deficiency in proteasome maturase Ump1 in Saccharomyces cerevisiae.
UMP1 has a role in Saccharomyces cerevisiae protein oxidation and autophagic cell death
Title: RNA interference toward UMP1 induces proteasome inhibition in Saccharomyces cerevisiae: evidence for protein oxidation and autophagic cell death.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome assembly	IEA Inferred from Electronic Annotation more info
involved_in proteasome assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteasome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

NP_009732.1

Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly