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    csn2 COP9/signalosome complex subunit Csn2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 3361420, updated on 18-Sep-2024

    Summary

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    Official Symbol
    csn2
    Official Full Name
    COP9/signalosome complex subunit Csn2
    Primary source
    PomBase:SPAPB17E12.04c
    Locus tag
    SPOM_SPAPB17E12.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See csn2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003424.3 (1272557..1274536, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SMN complex subunit Yip12/Gem2 Neighboring gene ubiquitin-protein ligase E3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL37 Neighboring gene protein sos7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion mutants in COP9/signalosome subunits in fission yeast Schizosaccharomyces pombe display distinct phenotypes. Mundt KE, et al. Mol Biol Cell, 2002 Feb. PMID 11854407, Free PMC Article
    2. Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome. Lin H, et al. Proc Natl Acad Sci U S A, 2020 Feb 25. PMID 32047038, Free PMC Article
    3. Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase. Liu C, et al. EMBO J, 2005 Nov 16. PMID 16252005, Free PMC Article
    4. CAND1 controls in vivo dynamics of the cullin 1-RING ubiquitin ligase repertoire. Wu S, et al. Nat Commun, 2013. PMID 23535663, Free PMC Article
    5. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Lyapina S, et al. Science, 2001 May 18. PMID 11337588

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables inositol hexakisphosphate binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deneddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    COP9/signalosome complex subunit Csn2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1272557..1274536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018700.3 → NP_001018220.1  COP9/signalosome complex subunit Csn2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_001018220.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9HFR0
      Conserved Domains (2) summary
      COG5159
      Location:48 → 418
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:311 → 415
      PCI; PCI domain
    Nucleotide Protein
    Heading Accession and Version

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