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    YMC2 organic acid transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852401, updated on 28-Oct-2024

    Summary

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    Official Symbol
    YMC2
    Official Full Name
    organic acid transporter
    Primary source
    SGD:S000000308
    Locus tag
    YBR104W
    See related
    AllianceGenome:SGD:S000000308; FungiDB:YBR104W; VEuPathDB:YBR104W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables organic acid transmembrane transporter activity. Involved in mitochondrial transport and transmembrane transport. Located in mitochondrion. Orthologous to several human genes including SLC25A29 (solute carrier family 25 member 29). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See YMC2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (449667..450656)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene exocyst subunit EXO84 Neighboring gene Sif2p Neighboring gene glucose-induced degradation complex subunit VID24 Neighboring gene Snd3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular identification and functional characterization of a novel glutamate transporter in yeast and plant mitochondria. Porcelli V, et al. Biochim Biophys Acta Bioenerg, 2018 Nov. PMID 30297026
    2. Mitochondrial transporters involved in oleic acid utilization and glutamate metabolism in yeast. Trotter PJ, et al. Arch Biochem Biophys, 2005 Oct 1. PMID 16140254
    3. Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae. el Moualij B, et al. Yeast, 1997 May. PMID 9178508
    4. Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation. Sanchez A, et al. Proc Natl Acad Sci U S A, 2020 Dec 1. PMID 33199619, Free PMC Article
    5. Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes. del Alamo M, et al. PLoS Biol, 2011 Jul. PMID 21765803, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables organic acid transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial L-ornithine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    organic acid transporter
    NP_009662.3
    • Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      449667..450656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178452.3 → NP_009662.3  TPA: organic acid transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009662.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQA3, P38087
      UniProtKB/TrEMBL
      B3LN49, B5VE67, C7GUK2, D3UEJ7, G2W9A9, N1P8E7
      Conserved Domains (1) summary
      pfam00153
      Location:235 → 328
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38087.1

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