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    tif452 translation initiation factor eIF4E, 4F complex E subunit isoform 2, stress response factor [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539870, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tif452
    Official Full Name
    translation initiation factor eIF4E, 4F complex E subunit isoform 2, stress response factor
    Primary source
    PomBase:SPBC1709.18
    Locus tag
    SPOM_SPBC1709.18
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPBC409.01
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    Genomic context

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    See tif452 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003423.3 (1134394..1135619)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene peptide N-glycanase Neighboring gene mRNA processing protein Cft2 Neighboring gene aromatic ring-opening dioxygenase Neighboring gene ncRNA Neighboring gene putative folylpolyglutamate synthase Neighboring gene ncRNA Neighboring gene NifU-like protein nfu1 Neighboring gene MIS12/MIND complex Mis12 Neighboring gene protein Swi5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. eIF4E isoform 2 in Schizosaccharomyces pombe is a novel stress-response factor. Ptushkina M, et al. EMBO Rep, 2004 Mar. PMID 14968130, Free PMC Article
    2. A genetic screen to discover pathways affecting cohesin function in Schizosaccharomyces pombe identifies chromatin effectors. Chen Z, et al. G3 (Bethesda), 2012 Oct. PMID 23050226, Free PMC Article
    3. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article
    4. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    translation initiation factor eIF4E, 4F complex E subunit isoform 2, stress response factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1134394..1135619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021360.3 → NP_595451.1  translation initiation factor eIF4E, 4F complex E subunit isoform 2, stress response factor [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595451.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74743, Q9UUB9
      Conserved Domains (1) summary
      COG5053
      Location:16 → 243
      CDC33; Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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