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    CNM1 Cnm1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852356, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CNM1
    Official Full Name
    Cnm1p
    Primary source
    SGD:S000000267
    Locus tag
    YBR063C
    See related
    AllianceGenome:SGD:S000000267; FungiDB:YBR063C; VEuPathDB:YBR063C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in organelle localization by membrane tethering. Is active in mitochondrial outer membrane; nuclear envelope; and organelle membrane contact site. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See CNM1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (366970..368184, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase TRM7 Neighboring gene uncharacterized protein Neighboring gene Ecm2p Neighboring gene Nrg2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cnm1 mediates nucleus-mitochondria contact site formation in response to phospholipid levels. Eisenberg-Bord M, et al. J Cell Biol, 2021 Nov 1. PMID 34694322, Free PMC Article
    2. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549
    3. Complete DNA sequence of yeast chromosome II. Feldmann H, et al. EMBO J, 1994 Dec 15. PMID 7813418, Free PMC Article
    4. A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A. Ciftci-Yilmaz S, et al. Genetics, 2018 Sep. PMID 30012561, Free PMC Article
    5. Association of yeast Upf1p with direct substrates of the NMD pathway. Johansson MJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 26. PMID 18087042, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in organelle localization by membrane tethering IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in organelle membrane contact site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cnm1p
    NP_009619.1
    • Molecular tether on nuclear membrane; mediates contact by interacting with Tom70p on mitochondria; protein abundance is regulated by phosphatidylcholine, enabling coupling of phospholipid homeostasis with contact extent

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      366970..368184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178411.1 → NP_009619.1  TPA: Cnm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ63, P38083
      UniProtKB/TrEMBL
      G2W969, N1P6I2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38083.1

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